7 research outputs found
NADPH-dependent clearance and transformation of 5ESL to 5ESLO in liver microsomes from four species of butterflyfish and recombinant human CYP3A4.
<p>Different letters indicate significant (P ≤ 0.05) differences between species* indicated signifcnat differences between control and pretreated <i>C</i>. <i>unimaculatus</i> (P ≤ 0.05) (N = 6–8).</p
Effects of dietary exposure to <i>S</i>.<i>maxima</i> tissue homogenate on the hepatic content CYP2K1-like and CYP2M1-like (A, B) and catalytic activity (C) of and CYP2 in four species of butterflyfish.
<p>Different letters indicate significant (P ≤ 0.05) differences between untreated and treated fish (N = 6–8).</p
The percentage survival of butterflyfish after a 7 day oral exposure to high dose (3.0mg/kg), or low dose (1.0mg/kg) of 5ESL.
<p>Each value represents the total survival of 6–8 individuals.</p
Structures of 5ESL (A) of <i>S</i>. <i>maxima</i> and 5ESL 15,16 epoxide (5ESLO) (B).
<p>Structures of 5ESL (A) of <i>S</i>. <i>maxima</i> and 5ESL 15,16 epoxide (5ESLO) (B).</p
Effects of dietary exposure to <i>S</i>.<i>maxima</i> tissue homogenate on the hepatic content (A) and catalytic activity (B, C) of and CYP3A in four species of butterflyfish.
<p>Different letters indicate significant (P ≤ 0.05) differences between untreated and treated fish (N = 6–8).</p
Effects of dietary exposure to 5ESL on the hepatic content of CYP2M1-like protein (A) and catalytic activity (B) of and CYP2 in four species of butterflyfish.
<p>Different letters indicate significant (P ≤ 0.05) differences between untreated and treated fish (N = 6–8).</p
Anticancer Activity of Region B Capsaicin Analogs
The heterocyclic vanilloid compound capsaicin is responsible
for
the spicy and pungent flavor of chili peppers. Several convergent
studies have shown that capsaicin suppresses the growth of multiple
human cancers. Apart from capsaicin, natural and synthetic capsaicin-like
compounds display growth suppressive activity in human cancers. The
pharmacophore of capsaicin is comprised of three regions, namely region
A (the aromatic ring), region B (the amide bond), and region C (the
side chain). The present manuscript describes the isolation and synthesis
of capsaicin analogs which have structural modifications in region
B of the molecule. Furthermore, the pharmacokinetic properties, anticancer
activity of region B capsaicin analogs, as well as the signaling pathways
(underlying the growth-inhibitory effects of region B capsaicin analogs)
have also been described. The discovery of novel, second-generation
region B capsaicin analogs may foster the hope of innovative nutrition-based
combination therapies in human cancers