Guía del Bajo Aragón

Guía elaborada por el alumnado del Instituto de Bachillerato de Andorra, para conocer la comarca bajoaragonesa. Se describen los pueblos de : Alacón, Albalate del Arzobispo, Alcañiz, Alcorisa, Alloza, Andorra, Ariño, Calanda, Hijar, La Puebla de Hijar, Molinos, Muniesa, Oliete, Samper de Calanda, su historia, el recorrido por sus calles y sus tradiciones. Asimismo, y por su gran interés turístico, se describe la Semana Santa en el Bajo Aragón.AragónBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

Cluster-Partial Least Squares (c-PLS) regression analysis: application to miRNA and metabolomic data

<p>This study introduces a novel variable selection approach called cluster PLS (c-PLS) that aims to assess the joint impact of variable groups selected based on biological characteristics (such as miRNA-regulated metabolic pathway) on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using a miRNomic datasets obtained from the analysis of 24 liver tissue biopsies collected in the frame of a clinical study of steatosis.</p><p>Results obtained show that c-PLS enables analyzing the effect of biologically relevant variable clusters, facilitating the identification of biological processes associated with the independent variable, and the prioritization of the biological factors influencing model performance, thereby improving the understanding of the biological factors driving model predictions. While the strategy is tested for the evaluation of PLS models, it could be extended to other linear and non-linear multivariate models.</p>GQ acknowledges the grant PID2021-125573OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by ERDF A way of making Europe, by the "European Union". JK acknowledges the financial support by the Instituto de Salud Carlos III [grant numbers PI20/00964 and CPII21/00003] (Co-funded by European Regional Development Fund "A way to make Europe"). RJ acknowledges grant PI20/00690 funded by Instituto de Salud Carlos III-FIS (Co-funded by European Regional Development Fund "A way to make Europe"). D.P.-G. acknowledges the financial support of the 2019 Ramón y Cajal (RYC) Contract Aids (RYC2019-026556-I) funded by MCIN/AEI/10.13039/501100011033 and FSE "El FSE invierte en tu futuro'' and the grant RPID2020-119326RA-I0 funded by MCIN/AEI/10.13039/501100011033. MMT acknowledges the grant RYC2021-031346-I, funded by MCIN/AEI/10.13039/501100011033 and by the European Union "NextGenerationEU''/PRTR