DTI maps show negative fractional anisotropy (FA) (A), and positive mean diffusivity (MD) (B) and radial diffusivity (RD) (C) correlations with Wisconsin Card Sorting Test (WCST) Errors in all cirrhotic patients.

<p>Results are shown with a Threshold-Free Cluster Enhancement method at p<0.05 corrected. Rows show selected coronal, sagital and axial maxima coordenate slices on a MNI152 brain template image (MNI coordinates). Red-yellow voxels are negatively correlated FA values (A), blue-lightblue voxels are positively correlated MD values (B) and brown-lightbrown are positively correlated RD values (C) with WCST Errors scores. FWE = Family Wise Error; SLF = superior longitudinal fasciculus; CST = corticospinal tract; ILF = inferior longitudinal fasciculus; IFO = inferior frontal-occipital; CC = corpus callosum; CG = cingulate gyrus; UF = uncinate fasciculus; HC = hippocampus.</p

Neuromuscular evaluation of patients with falls and patients without falls.

<p>^a MRC: Medical Research Council.</p><p>^b ICARS: International Cooperative Ataxia Rating Scale.</p><p>^c UPDRS-III: Unified Parkinson’s Disease Rating Scale-part III.</p><p>Neuromuscular evaluation of patients with falls and patients without falls.</p

DTI maps show reduced fractional anisotropy (FA) (A) and increased radial diffusivity (RD) (B) in patients with falls compared to those without falls, including Psychometric Hepatic Encephalopathy Score (PHES) as a covariate.

<p>Results are shown with a Threshold-Free Cluster Enhancement method at p<0.05 corrected. Rows show selected coronal, sagital and axial maxima coordenate slices on a MNI152 brain template image (MNI coordinates). Red voxels have significantly decreased FA values (A), and brown-lightbrown voxels have significantly increased RD values (B). FWE = Family Wise Error; SLF = superior longitudinal fasciculus; CST = corticospinal tract; ILF = inferior longitudinal fasciculus; IFO = inferior frontal-occipital; CC = corpus callosum; CG = cingulate gyrus.</p

Neuropsychological tests in patients with falls and patients without falls.

<p>^a Mini-Mental State Examination.</p><p>^b Parkinson’s Disease-Cognitive Rating Scale.</p><p>^c PHES: Psychometric Hepatic Encephalopathy Score.</p><p>^d WCST: Wisconsin Sorting Card Test.</p><p>Higher values indicate better results in all tests except for Number Connection Test A and B, Line Tracing Test, Serial Dotting Test and WCST Errors.</p><p>Neuropsychological tests in patients with falls and patients without falls.</p

DTI maps show reduced fractional anisotropy (FA) (A) and increased mean diffusivity (MD) (B) and radial diffusivity (RD) (C) in patients with falls compared to those without falls.

<p>Results are shown with a Threshold-Free Cluster Enhancement method at p<0.05 corrected. Rows show results of selected coronal, sagital and axial coordenate slices on a MNI152 brain template image (MNI coordinates). Green voxels represent the FMRIB58 white matter skeleton mask. Red voxels have significantly decreased FA values (A), blue voxels imply significantly increased MD (B) and lightbrown voxels represent increased RD values (C). FWE = Family Wise Error; SLF = superior longitudinal fasciculus; CST = corticospinal tract; ILF = inferior longitudinal fasciculus; IFO = inferior frontal-occipital; CC = corpus callosum; CG = cingulate gyrus.</p

Clinical and analytical characteristics of patients with falls and patients without falls.

<p>^a Model for end-stage liver disease.</p><p>^b Modified Charlson index.</p><p>^c <3/10 using decimal Snellen number chart.</p><p>Clinical and analytical characteristics of patients with falls and patients without falls.</p

Cerebral MRI findings visually assessed in cirrhotic patients with falls and in those without falls.

<p>Cerebral MRI findings visually assessed in cirrhotic patients with falls and in those without falls.</p