7 research outputs found
White matter lesions in cronic migraine are not associated with changes in pulsatility index
International Headache Congress (IHC) of the International-Headache-Society (18th. Vancouver, CANADA. 2017
EHMTI-0105. CGRP and VIP levels as predictors of efficacy of onabotulinumtoxin type A in chronic migraine
CGRP and VIP Levels as Predictors of Efficacy of Onabotulinumtoxin Type A in Chronic Migraine
Long-term experience with onabotulinumtoxinA in the treatment of chronic migraine: What happens after one year?
White matter lesions in cronic migraine are not associated with cerebral vasoreactivity
International Headache Congress (IHC) of the International-Headache-Society (18th. Vancouver, CANADA. 2017
No association between migraine frequency, white matter lesions and silent brain infarctions: a study in a series of women with chronic migraine
Background and purpose: It has been suggested that silent infarctions (SIs) and hyperintense white matter lesions (WMLs) are related to migraine frequency. We studied their prevalence and anatomical distribution in patients with chronic migraine (CM).
Methods: A total of 96 women with CM [mean age 43 (range 16-65) years] and 29 women with episodic migraine (EM) [mean age 36 (range 16-58) years] underwent 1.5-T magnetic resonance imaging following the CAMERA protocol. The number, size and location of SIs and deep WMLs were recorded and a modified Fazekas scale was applied to assess periventricular WMLs.
Results: White matter lesions were found in 59 (61.5%) women with CM and 17 (58.6%) women with EM (odds ratio, 1.13; 95% confidence intervals, 0.48-2.62; P = 0.784). The majority (63% CM and 71% EM) were small deep WMLs. Exclusive periventricular WMLs were exceptional. Of the 739 WMLs seen in patients with CM, 734 (99.3%) were hemispheric and mostly frontal (81%). Posterior fossa WMLs were seen in only five (5.2%) women with CM (always in the pons) and two (6.9%) women with EM. Age >45 years was the only vascular risk factor associated with a higher WML number (median: 0 45 years; P = 0.004). We found seven SIs in six women with CM (6.3%).
Conclusions: As compared with the expected prevalence at this age, this study confirms that the prevalence of WMLs, in most cases small, deep and frontal, was increased in CM and EM. However, our results do not support an association of WMLs or SIs with a higher frequency of attacks, but with the presence of vascular risk factors and mainly age >45 years.Acknowledgments: This work was supported by Pl14/00020 FISSS grant Plan Nacional I+D+I, Fondos Feder, ISCIII, Ministry of Economy, Spai