Reusing Human Resources Management Standards for Employment Services

Employment Services (ESs) are becoming more and more important for Public Administrations where their social implications on sustainability, workforce mobility and equal opportunities play a fundamental strategic importance for any central or local Government. The EU SEEMP project aims at improving facilitate workers mobility in Europe. Ontologies are used to model descriptions of job offers and curricula; and for facilitating the process of exchanging job offer data and CV data between ES. In this paper we present the methodological approach we followed for reusing existing human resources management standards in the SEEMP project, in order to build a common “language” called Reference Ontology

An Ontology for Modelling Human Resources Management based on Standards

Employment Services (ES) are becoming more and more important for Public Administrations where their social implications on sustainability, workforce mobility and equal opportunities play a fundamental strategic importance for any central or local Government. The EU SEEMP (Single European Employment Market-Place) project aims at improving facilitate workers mobility in Europe. Ontologies are used to model descriptions of job offers and curricula; and for facilitating the process of exchanging job offer data and CV data between ES. In this paper we present the methodological approach we followed for reusing existing human resources management standards in the SEEMP project, in order to build a common “language” called Reference Ontology

Methodology for Reusing Human Resources Management Standards

Employment Services (ESs), Public ones (PESs) and Private ones (PrEAs), are becoming more and more important for Public Administrations where their social implications on sustainability, workforce mobility and equal opportunities play a fundamental strategic importance for any central or local Government. The EU SEEMP (Single European Employment Market-Place) project aims at improving facilitate workers mobility in Europe. Ontologies are used to model descriptions of job offers and curricula; and for facilitating the process of exchanging job offer data and CV data between ES. In this paper we present the methodological approach we followed for reusing existing human resources management standards like NACE, ISCO-88 (COM) and FOET, among others, in the SEEMP project, in order to build a common “language” called Reference Ontology

Genetic study in patients operated dentally and anesthetized with articaine-epinephrine

Aims: In this study we wanted to figure out if there was a correlation between OPRM1 N40D, TRPV1 I316M, TRPV1 I585V, NOS3 −786T>C and IL6 −174C>G polymorphisms and the response to locally applied articaine-epinephrine anesthetic. Methods: In this observational study, 114 oral cell samples of patients anesthetized with articaine-epinephrine (54 from men 60 from women), were collected from dental centers in Madrid (Spain). High molecular weight DNA was obtained from oral mucosa cells. The analysis of OPRM1 N40D (rs1799971), TRPV1 I316M (rs222747), TRPV1 I585V (rs8065080) and IL6 −174C>G polymorphism was performed through real-time PCR allelic discrimination using TaqMan probes. Polymorphism NOS3 −786T> C (rs2070744) was analyzed using RFLP-PCR. Results: The studied polymorphisms are involved neither in the response to the anesthetic, nor in the intensity of perceived dental pain. However, in a subset of female patients we found that TRPV1 I316M was associated with a delayed onset of anesthesia. Conclusions: There is no association among these polymorphisms and the time elapsed between the application of the anesthetic and the onset of its effect

Overexpression of the mitochondrial pyruvate carrier increases CHO cell and recombinant protein productivity and reduces lactate production

The metabolism of CHO cells is characterized by a low efficiency of glucose metabolism, resulting in lactate production. We hypothesized that the cause of such low efficiency is a slow transportation of pyruvate into the mitochondria. The mitochondrial pyruvate carrier (mpc), responsible of introducing pyruvate into the mitochondria, is formed of two subunits, mpc1 and mpc2. We constructed stable CHO cell lines overexpressing both genes in order to facilitate the entry of pyruvate into the mitochondria and its incorporation into oxidative pathways. Overexpression of both genes was verified by qPCR and Western Blot, showing a significant increase compared to the basal level on the control cells. Kinetic evaluation of the CHO-mpc cells showed a 50% reduction of the lactate concentration respect to the control. Cell growth rate and maximum concentration were also increased, and an increase of 40% on the production of recombinant secreted placental alkaline phosphatase was observed. We show that transport of pyruvate into the mitochondria limits the efficiency of oxidation of glucose, which can be overcome by a cell engineering approach. Financial support by UNAM-DGAPA-PAPIIT IT-200315 and SEP-CONACyT Ciencia Básica 255445

Análisis del espesor coroideo en pacientes con queratocono

Objective. To determine and compare choroidal thickness (CT) in keratoconus (KC) patients using Enhanced Depth Imaging (EDI) OCT. Methods. A comparative cross-sectional study including 26 patients with KC and 26 healthy controls assessed with Pentacam and EDI-OCT. CT was measured manually with the Caliper function at thirteen locations at 500 µm regular intervals. Results. The average CT in T6 was 253.96 ± 88.95 μm in the KC group, and of 309.39 ± 94.11 μm in the control group (p <0.041). No significant differences in mean CT were observed in the rest of the points, including the subfoveal CT (M), 351.48 ± 106.3 vs 365.35 ± 114.6 μm, (p = 0.66). No correlation was observed between the mean subfoveal CT (M), the mean CT in the KC group, and the values of K1 (p = 0.977 and p = 0.498 respectively), K2 (p = 0.450 and p = 0.656), corneal asphericity (Q ) (p = 0.986 and p = 0.902), minimal pachymetry (Pachy) (p = 0.408 and p = 0.688), keratoconus index (KI) (p = 0.601 and p = 0.217), vertical asymmetry index (VAT) (p = 0.296 and p = 0.523), staging of KC (TKC) (p = 0.549 and p = 0.08) and corneal apex morphology. Conclusion. Significant lower CT was found in the KC group in T6 (3000 μm temporal to the fovea). No significant difference of CT values in KC patients and healthy subjects was found in the other twelve measurement locations.We found no association between the refractive and keratometric indexes obtained by corneal topography and subfoveal CT.Objetivo. Determinar y comparar el grosor de la coroides (CT) en pacientes con queratocono (KC) usando OCT con Enhanced Depth Imaging (EDI). Métodos. Estudio comparativo transversal que incluye 26 pacientes con KC y 26 controles sanos evaluados con Pentacam y EDI-OCT. El KC fue medido manualmente con la función Caliper en trece puntos a intervalos regulares de 500 µm. Resultados. El promedio de CT en T6 fue de 253,96 ± 88,95 μm en el grupo KC, y de 309,39 ± 94,11 μm en el grupo de control (p <0,041). No se observaron diferencias significativas en la media de CT en el resto de los puntos, incluyendo el CT subfoveal (M), 351.48 ± 106.3 vs 365.35 ± 114.6 μm, (p = 0.66). No se observó ninguna correlación entre la media de CT (M) subfoveal, la media de CT en el grupo KC, y los valores de K1 (p = 0,977 y p = 0,498 respectivamente), K2 (p = 0,450 y p = 0,656), la asfericidad corneal (Q) (p = 0,986 y p = 0. 902), paquimetría mínima (Pachy) (p = 0,408 y p = 0,688), índice de queratocono (KI) (p = 0,601 y p = 0,217), índice de asimetría vertical (VIA) (p = 0,296 y p = 0,523), estadificación del KC (TKC) (p = 0,549 y p = 0,08) y morfología del ápice corneal. Conclusión. Se observó un CT significativamente menor en el grupo KC en T6 (3000 μm temporal a la fóvea). No se encontraron diferencias significativas entre los valores del CT en los pacientes con KC y en los sujetos sanos en los 12 puntos de medida restantes. No se encontró ninguna asociación entre los índices refractivos y queratométricos obtenidos por la topografía corneal y el CT subfoveal