Hemorrhagic infarction secondary to cerebral venous thrombosis

Cerebral venous thrombosis (CVT) is an uncommon cause of hemorrhagic stroke. A 47-year old woman presented with acute-onset global aphasia and right hemiplegia. Head CT revealed a large left frontoparietal hematoma with significant mass effect. Emergency decompressive hemicraniectomy and hematoma evacuation were thus indicated. Intraoperatively, an occlusive thrombus was identified in the superior anastomotic vein of Trolard, confirming the diagnosis of CVT. While hemorrhagic CVT is not a rare entity, the diagnosis is not usually made intraoperatively. More interestingly, the authors provide intraoperative photographs of the occlusive thrombus in the vein of Trolard, overlying the area of hemorrhage, which they believe are unique and compelling clinical images. Keywords: Cerebral venous thrombosis, Dural sinus thrombosis, Intracerebral hemorrhage, Superior anastomotic vein of Trolard, Thrombophilia, Venous infarctio

Identification of innate immunity genes and pathways using a comparative genomics approach

To reveal regulators of innate immunity, we used RNAi assays to monitor the immune response when genes are inhibited in Caenorhabditis elegans and mouse macrophages. Genes that altered innate immune responsiveness in C. elegans were validated in murine macrophages, resulting in the discovery of 11 genes that regulate the innate immune response in both systems and the subsequent identification of a protein interaction network with a conserved role in innate immunity regulation. We confirmed the role of four of these 11 genes in antimicrobial gene regulation using available mutants in C. elegans. Several of these genes (acy-1, tub-2, and tbc-1) also regulate susceptibility to the pathogen Pseudomonas aeruginosa. These genes may prove critical to understanding host defense and represent potential therapeutic targets for infectious and immunological diseases