Comparison of ⁶⁸Ga-DOTATATE uptake and MR contrast agent enhancement.

<p>In all 3 patients, there is a marked overlap between ⁶⁸Ga-DOTATATE uptake and MR contrast agent enhancement. Radiotracer accumulation is most pronounced in areas with intense contrast enhancement. Shown are axial views of contrast-enhanced T1-weighted MR as well as fused MR/PET images.</p

Correlation between histological macrophage infiltration (visual assessment) and ⁶⁸Ga-DOTATATE uptake in three different samples of GBM.

<p>Correlation between histological macrophage infiltration (visual assessment) and ⁶⁸Ga-DOTATATE uptake in three different samples of GBM.</p

Tracer distribution of ⁶⁸Ga-DOTATATE in GBM.

<p>Three examples of increased ⁶⁸Ga-DOTATATE uptake in Glioblastoma multiforme. Markedly, partly inhomogeneous tracer accumulation can be depicted in each patient. Shown are axial views of CT, SSTR-PET as well as fused PET/CT images.</p

Immunohistochemical staining of SSTR2A (sample of patient #15).

<p>(A) non-tumoral cortex with strong reaction in neurons (arrows) and neuropile (magnification: 100x). Left inset: Negative control. Right inset: positive control (normal pancreas) with strong reaction in an islet of Langerhans. (B) CD68 staining depicting high microglia/macrophage infiltration area and (C) SSTR2A immunostaining of an adjacent area showing strong reaction in endothelium (arrows) and in single glioma cells (arrowheads) (magnification: 100x).</p

Distribution of macrophage infiltration, tumor cell burden and proliferation (visual assessment) in GBM samples.

<p>Distribution of macrophage infiltration, tumor cell burden and proliferation (visual assessment) in GBM samples.</p

Potential risk factors for DCI.

Results from the logistic regression analysis expressed in odds ratio for the occurrence of DCI.</p

Total occurrence and type of intervention for vasospasm.

Total occurrence and type of intervention for vasospasm.</p

Baseline characteristics of the entire cohort consisting of 104 patients.

Baseline characteristics of the entire cohort consisting of 104 patients.</p

Potential risk factors for poor outcome.

Results from the univariate anaylsis expressed with a p-value as well as results from the subsequent logistic regression analysis expressed in odds ratio and p-value.</p

S1 Dataset -

BackgroundOne of the longest-standing treatments to prevent delayed cerebral infarction (DCI) in patients with aneurysmal subarachnoid hemorrhage (aSAH) remains raising the blood pressure to a certain level of mean arterial pressure. This may require high doses of norepinephrine, which has been associated with severe end organ damage. With this study, we aimed to investigate the effects of norepinephrine on the incidence of DCI in a clinical setting.MethodsWe conducted a retrospective evaluation of patients with aSAH admitted to our institution between November 2018 and March 2021. Potential risk factors for DCI were analyzed and significant predictors were assessed by means of a logistic regression analysis to account for potential confounders.ResultsIn this study, 104 patients were included. Hereof, 39 (38%) showed radiologic signs of DCI between day three and 14 post-intervention. These patients had more frequent vasospasms (n = 37 vs. 30, p = 0.022), a higher Hunt & Hess score (3 ± 2 vs. 2 ± 1, p = 0.004), a lower initial Glasgow Coma Scale score (9 ± 5 vs. 12 ± 4, p = 0.003) and received a higher median norepinephrine dose (20,356μg vs. 6,508μg, p ConclusionOur results indicate a significant association between higher dose norepinephrine administration and the occurrence of DCI. Future research including greater sample sizes and a prospective setting will be necessary to further investigate the relationship.</div