Der Pemphiguskomplex beim Kleintier - Pathogenese, Symptome, Diagnose und Therapie. Eine Literaturstudie.

Nach einem Überblick über die Pathogenese des Pemphiguskomplexes werden die Symptome und die Diagnose dieser autoimmunbedingten Erkrankung beschrieben. Pemphigus ist durch primär vesikulobullöse Veränderungen der Haut und der mukokutanen Übergänge gekennzeichnet, die s i ch in kürzester Zeit zu Erosionen, Krusten und Ulzera entwickeln. Die Primärvesikel werden durch sogenannte Pemphigusantikörper gegen Antigene der epidermalen, interzellulären Zementsubstanz hervorgerufen. Vorbericht und Symptome weisen auf die Diagnose hin, die durch Zytologie, Histopathologie und Immunfluoreszenztests gesichert wird. Verschiedene Therapiemöglichkeiten mit immunsuppressiven Medikamenten sowie die Prognosen der Pemphigusformen werden besprochen

Critically appraised topic on adverse food reactions of companion animals (2): common food allergen sources in dogs and cats

Background: To diagnose cutaneous adverse food reactions (CAFRs) in dogs and cats, dietary restriction-provocation trials are performed. Knowing the most common offending food allergens for these species would help determining the order of food challenges to optimize the time to diagnosis. Results: The search for, and review and analysis of the best evidence available as of January 16, 2015 suggests that the most likely food allergens contributing to canine CAFRs are beef, dairy products, chicken, and wheat. The most common food allergens in cats are beef, fish and chicken. Conclusions: In dogs and cats, after a period of dietary restriction leading to the complete remission of clinical signs, food challenges to diagnose CAFR should begin with beef and dairy products, the most commonly recognized food allergens in these two species

Critically appraised topic on adverse food reactions of companion animals (2): common food allergen sources in dogs and cats

Background: To diagnose cutaneous adverse food reactions (CAFRs) in dogs and cats, dietary restriction-provocation trials are performed. Knowing the most common offending food allergens for these species would help determining the order of food challenges to optimize the time to diagnosis. Results: The search for, and review and analysis of the best evidence available as of January 16, 2015 suggests that the most likely food allergens contributing to canine CAFRs are beef, dairy products, chicken, and wheat. The most common food allergens in cats are beef, fish and chicken. Conclusions: In dogs and cats, after a period of dietary restriction leading to the complete remission of clinical signs, food challenges to diagnose CAFR should begin with beef and dairy products, the most commonly recognized food allergens in these two species

Makroskopisch-Anatomische Untersuchungen zum Plexus lumbosacralis der Katze.

SIGLEAvailable from: Zentralstelle fuer Agrardokumentation und -information (ZADI), Villichgasse 17, D-53177 Bonn / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Cross‐reactive carbohydrate determinants in atopic and healthy dogs and their influence on allergy test specificity

Background The selection of allergens for immunotherapy in atopic dogs is often based on serum allergy testing. Cross-reactive carbohydrate determinants (CCDs) are common structures in plant and insect allergens that reportedly induce polysensitisation, reduce agreement between intradermal and serum tests and complicate allergen selection. Methods Thirty-four dogs with diagnosed atopic dermatitis and 10 healthy dogs were included in the study. An intradermal test was conducted in atopic dogs, and serum samples from allergic and healthy dogs were analysed for allergen-specific immunoglobulin E (IgE) before and after inhibition of detectable anti-CCD-IgE antibodies. Results Anti-CCD-IgE antibodies were not found in any of the healthy dogs and no polysensitisation to plant and insect allergens was detected. The agreement between intradermal and serum allergy test results in the atopic dogs with anti-CCD-IgE antibodies improved from slight to fair after blocking the anti-CCD-IgE antibodies. In addition, blocking clearly reduced polysensitisation to plant allergens but not to acarid allergens. Limitations Only a limited number of healthy dogs were tested in this study. A gold standard for determining the clinical relevance of IgE sensitisation does not exist. Conclusion Inhibition of anti-CCD-IgE antibodies seems to be of importance to improve serum test specificity for allergen-specific IgE in atopic dogs in relation to intradermal allergy testing