Univariate and multivariate Cox-regression analysis.

<p>Results for univariate and multivariate Cox regression models. For every variable, the estimated hazard ratio HR and its corresponding 95% confidence interval are given, as well as the p-value when testing HR = 1. P-values below 0.05 are marked with a star (*). The categorical variable WHO grade is treated as factor variable, thus HR refers to the comparison of WHO grade II and WHO grade III, respectively, to WHO grade I.</p

GLEA2 seroreactivity.

<p>(A) Comparison of GLEA2 seroreactivity between glioblastoma patients, healthy volunteers, and lung cancer patients as control groups. The differences between the controls and the glioblastoma patients group were statistically significant. The difference between the two control groups was not significant. (B) Comparison of GLEA2 seroreactivity between glioblastoma patients prior to surgery, after surgery, prior to radiation, during radiation and after radiation. The differences were significant between pre-radiation and during radiation. Black bars correspond to median values, the dazed lines to the 75% quantiles, circles represent outliers.</p

Demonstration of PCR products of <i>TIMP3</i> in gelelectrophoresis: MN 123 and MN 60 = patients with positive methylation status of <i>TIMP3</i>.

<p>MN 2 =  patient without methylation.</p

Individual course of GLEA2 seroreactivity.

<p>Each mark represents the GLEA2 value of a single patient. (A) Comparison of GLEA2 seroreactivities prior and after surgery. (B) Comparison of GLEA2 seroreactivities after surgery and prior to radiation. (C) Comparison of GLEA2 seroreactivities prior and during radiation. (D) Comparison of GLEA2 seroreactivities during and after radiation. On the right of each figure, a histogram of the quotient of GLEA2 values at the two time points is shown.</p

Figure 1

<p><b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094987#pone-0094987-g001" target="_blank">Figure 1a:</a></b> Two color FISH for chromosome 1p36/22q11 (Metasystems). <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094987#pone-0094987-g001" target="_blank"><b>Figure 1b:</b></a> Probe map for dualcolor probe 1p36/9p21 and 22q11 (Metasystems).</p

Multivariate Cox-regression analysis with variable selection by AIC criterion.

<p>Results for multivariate Cox regression models with variable selection. For every variable, the estimated hazard ratio HR and its corresponding 95% confidence interval are given, as well as the p-value when testing HR = 1. The categorical variable WHO grade is treated as factor variable, thus HR refers to the comparison of WHO grade II and WHO grade III, respectively, to WHO grade I. The full model before variable selection included the additional variables age, p16, and 9p which were eliminated by stepwise backward selection with standard AIC (Akaike Information Criterion) as model selection criterion. All estimates and p-values in the table are close to the corresponding values before variable selection (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094987#pone-0094987-t003" target="_blank">Table 3</a>).</p

Kaplan-Meier survival curves for times to recurrence of meningioma patients; patients are split into 3 subgroups according to WHO grades.

<p>Kaplan-Meier survival curves for times to recurrence of meningioma patients; patients are split into 3 subgroups according to WHO grades.</p

Correlation between clinical variables and deletion of 1p36.

<p>Correlation between clinical variables and deletion of 1p36.</p

Kaplan-Meier survival curves for time of recurrences of meningioma patients; patients are split into 2 subgroups according to Deletion of 1p36.

<p>Kaplan-Meier survival curves for time of recurrences of meningioma patients; patients are split into 2 subgroups according to Deletion of 1p36.</p