On the prodrug-potential of novel Aldose reductase inhibitors with diphenylmethyleneaminooxycarboxylic acid structure

A series of aldose reductase inhibitors as prodrugs have been synthesized and their stability in biological fluids assessed

Structured and Unstructured Computations on the DLR-F4 Wing-Body Configuration

The accuracy of the DLR structured and unstructured computational fluid dynamic (CFD) codes in predicting aircraft forces and moments on a wing-body configuration at transonic speeds is investigated. The computations form the contribution of the DLR and Airbus Deutschland to the AIAA CFD Drag Prediction Workshop in June 2001. Using a combination of a high quality grid, low levels of artificial dissipation and an advanced turbulence model, the structured code (FLOWer) was able to both qualitatively and quantitativele predict the experimentally measured drag, lift and pitching moments. In its current implementation the unstructured code (TAU) was found to be less accurate in predicting forces and moments, although qualitatively the results were good

Synthesis of novel benzoic acid derivatives with benzothiazolyl subunit and evaluation as aldose reductase inhibitors

Several methyl benzothiazolyloxybenzoates, S-isosters, and the corresponding benzoic acids were synthesized and tested as aldose reductase inhibitors (ARIs). Out of this series, the ester derivative 2a-7 was found to exhibit the highest enzyme-inhibitoric activity. In order to investigate this unexpected result, further modifications were carried out which allowed us to explain this finding and to open a path to a novel class of ARIs

Airbus, ONERA, and DLR Results from the Second AIAA Drag Prediction Workshop

The results from DLR, Airbus, and ONERA from the Second AIAA Computational Fluid Dynamics Drag Prediction Workshop are presented. The lift, drag, and pitching moments are calculated for the DLR-F6 configuration at transonic flow conditions by solving the Reynolds-averaged Navier-Stokes equations on structured as well as on unstructured, hybrid grids

A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors

In the course of our research aimed at the discovery of new compounds acting as aldose reductase inhibitors, we tested a series of some (E)- and (Z)-ω-[[(aryldiazinylmethylene)amino]oxy]alkanoic acids, which were found to have moderate in vitro inhibitory activity. On this basis we have now prepared several new derivatives modified both at the length of the chain and at its terminal carboxylic group, together with compounds carrying various substituents at the phenyl ring. This paper describes their synthesis and biological properties

Didactic/research

Considering the involvement of the researchers at all levels of the didactic, it may be assumed that the transmissibility of the architectonic composition is a question of priority for them, at least for two areas of the relationship research/didactic: research about the didactic and research through the didactic experimentation. Didactic and research come closer when it is understood that nothing is transmissible except thought means not teaching something already worked out, or well know, but to transmit an attitude towards to search. Contemporary pedagogy, appropriating Derrida's deconstruction, indicates in the form of awakening the method for a discipline that eschews the evidence, the convention, which is not deaf to the contingent event and everything that can be generated but has not yet been revealed