Quantum-Holographic Hopfield-like Biomolecular Recognition

Abstract-A possible decoherence-based quantum-holographic Hopfield-like approach to biomolecular recognition is considered. This might be of fundamental importance in understanding underlying macroscopic quantum-holographic Hopfield-like control mechanisms of morphogenesis, with significant potential holistic psychosomatic implications

Biomolekularno prepoznavanje - o mogućim kvantnim prilazima

Two unresolved issues of the (semi)classically addressed problems in molecular biophysics are unreasonably long time necessary for the change of biopolymer conformations and long-range directedness of selective biomolecular recognition processes - implying their essential quantum origin. In this paper several possible quantum approaches to biomolecular recognition are considered: Theory of Non-Radiative Resonant Structural Transitions, Model of Quantum Decoherence, and Resonant Recognition Model. These approaches might be of fundamental importance in understanding underlying macroscopic quantum-holographic Hopfield-like control mechanisms of morphogenesis, and their backward influence on the expression of genes, with significant potential psychosomatic implications.Dva nerazrešena pitanja semi-klasično postavljnih problema u molekularnoj biofizici jesu nerazumno dugo vreme potrebno za izmenu biomolekularnih konformacija i dugo-dometna usmerenost selektivnih procesa biomolekularnog prepoznavanja. U radu je razmotreno nekoliko mogućih kvantnih prilaza rešavanju ovih problema. Predloženi kvalitativni scenario je dovoljno opšti i čini dobru osnovu za principijelno rešenje problema biopolimernog sklupčavanja u nativnu konformaciju pri visoko selektivnim procesima protein/receptor biomolekularnog prepoznavanja, implicirajući makroskopsku kvantnu nelokalnost na biološkom ćelijskom nivou. (Bazična nelokalnost se može proširiti i na makroskopski kvantni nivo biološkog organizma na šta ukazuje makroskopska kvantna mikrotalasna rezonantna terapija akupunkturnog sistema.) Kvantna priroda ovih procesa ilustrovana je na primeru neradijativnih strukturnih prelaza, modelu kvantne dekoherencije i modelu rezonantnog prepoznavanja uz diskusiju implementirajućeg mehanizma elektronsko-konformacione sprege u ključ-brava uklapajućim konformacionim prelazima biomolekularnog prepoznavanja protein/supstrat. Na osnovu ovih prilaza u stanju smo da reprodukujemo kako egzistenciju i stabilnost (stacionarnih) polimernih konformacija tako i kratka vremena za kvantno -mehaničke procese u konformacionim prelazima u selektivnim procesima biomolekularnog prepoznavanja. Pošto ovi procesi dovode do dinamičke modifikacije više-elektronske hiperpovrši energija-stanje ćelijskog protein/receptor ansambalskog biomolekularnog makroskopskog kvantnog sistema, to otvara mogućnost razmatranja ćelijskog biomolekularnog prepoznavanja kao Hopfildove kvantno-holografske asocijativne neuronske mreže. Ovi prilazi mogu biti od fundamentalnog značaja za razumevanje bazičnih makroskopskih kvantno-holografskih Hopfildovih kontrolnih mehanizama morfogeneze i njihovog povratnog uticaja na ekspresiju genoma

NUMERICAL COMPUTATIONS OF TURBULENT FLOWTHROUGH ORIFICE FLOWMETER

Turbulent, incompressible flow through orifice flow meter is numerically investigated using OpenFOAM software. Turbulence is modeled using RANS approach, and three turbulence models are tested: standard k-e , k −w and Launder Sharma model. Results for pressure drop on the orifice are compared to experimental results and good agreement is found for all turbulent models, with the most accurate results obtained with k−e model. Velocity and pressure distribution in whole computational domain is analyzed, with special attention to the region in proximity to the orifice where primary and secondary vortex structures are detected. Additionally, numerical computations are also performed on automatically generated mesh using snappyHexMesh utility and similar results for the pressure drop are obtained as the ones on the block-structured grid

NUMERICAL COMPUTATIONS OF TURBULENT FLOWTHROUGH ORIFICE FLOWMETER

Turbulent, incompressible flow through orifice flow meter is numerically investigated using OpenFOAM software. Turbulence is modeled using RANS approach, and three turbulence models are tested: standard k-e , k −w and Launder Sharma model. Results for pressure drop on the orifice are compared to experimental results and good agreement is found for all turbulent models, with the most accurate results obtained with k−e model. Velocity and pressure distribution in whole computational domain is analyzed, with special attention to the region in proximity to the orifice where primary and secondary vortex structures are detected. Additionally, numerical computations are also performed on automatically generated mesh using snappyHexMesh utility and similar results for the pressure drop are obtained as the ones on the block-structured grid

An in situ temperature calibration of a guarded hot plate apparatus

This paper presents design, development, and testing of a custom-made calibration environment for the calibration of temperature sensors applied in a guarded hot plate apparatus for thermal conductivity measurements. Description of an in situ calibration principle and realization are introduced. Results of numerical simulation, as well as those of experimental validation are given in a separate section of the paper. According to the results, proposed in situ calibration by using the applied guarded hot plate apparatus elements improves both accuracy and traceability the of thermal conductivity measurement. © 2018 Serbian Society of Heat Transfer Engineers

On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield

In the context of the macroscopic quantum phenomena of the second kind, we hereby seek for a solution-in-principle of the long standing problem of the polymer folding, which was considered by Levinthal as (semi) classically intractable. To illuminate it, we applied quantum-chemical and quantum decoherence approaches to conformational transitions. Our analyses imply the existence of novel macroscopic quantum biomolecular phenomena, with biomolecular chain folding in an open environment considered as a subtle interplay between energy and conformation eigenstates of this biomolecule, governed by quantum-chemical and quantum decoherence laws. On the other hand, within an open biological cell, a system of all identical (noninteracting and dynamically noncoupled) biomolecular proteins might be considered as corresponding spatial quantum ensemble of these identical biomolecular processors, providing spatially distributed quantum solution to a single corresponding biomolecular chain folding, whose density of conformational states might be represented as Hopfield-like quantum-holographic associative neural network too (providing an equivalent global quantum-informational alternative to standard molecular-biology local biochemical approach in biomolecules and cells and higher hierarchical levels of organism, as well)

Dielectric Permeability of Nanocylinder

In the nanocylinder, a cut-off from the molecular crystal, dielectric permeability tensor is investigated. Excitons in the nanocylinder arise due to the exciting of the electron subsystem of the molecule. In evaluation of dielectric permeability Dzhyaloshinskii-Pitaevskii approach is used, connected with retarded and advanced exciton Green's functions and correct use of Paulion Green's function. It turned out that refraction and absorption indices depend on configuration coordinates, having maximal values at boundary cross-sections and minimal value at central cross-section of the nanocylinder broken symmetry structure. Although it was expected that boundary conditions make higher refractive and absorptive characteristics of the nanocylinder, this appeared not to be possible because Paulion Green's function is not proportional to the exciton concentration

Roll and importance of accumulation lake Gruža in bird migration

Artificial accumulation Lake Gruža fills the depression of the Knićko Field, situated between the mountains Gledićke and Kotlenik. It was formed mostly in order to provide water supply for industry and residential of the Kragujevac District. According to its advantage location, it lays on predicted moravsko-vardarskom migratory route. In this paper it has been showed ringing data within this area during autumn and spring migration of resident and transitory population of passerines and data obtained during the winter months, for lake’s surface is rarely frozen, so it presents wintering area for numerous waterfowl flocks. During the research, it has been recorded in total 153 bird species. The most abundant month was January, when there were detected 9577 waterfowl individuals from 29 species. During the spring and autumn migration, 370 bird individuals were banded, form 32 mostly passerines species. Ringing data showed that accumulation Gruža indeed has important roll in bird migration, along mentioned migratory route, for it enables the migrating birds to rest, regain their strength and recharge the energy supplies before continuing the migration. Moreover, importance of accumulation is greater when we know that significant number of wintering and migrating birds are rare and endangers, not only in Serbia, but allover the Europe

Fononska toplotna provodnost tankih kristalnih filmova

In this paper we have analyzed phonon thermal conductivity of thin crystalline films, i.e. of low-dimensional structures with dimensional parameters significantly decreased in only one direction. Finding of coefficient of thermal conductivity is achieved by deriving phonon coefficient of diffusion, phonon specific heat and specific density for explored structure. Coefficient of diffusion is derived by applying method of Green functions, using Kubo formula. Then reduced thermal conductivities for film and bulk structures were compared for wider temperature interval. In the last section an influence of changes of heat conductivity on the boundaries is analyzed.U radu je analizirana fononska toplotna provodnost u kristalnim filmovima, tj. niskodimenzionim strukturama kod kojih su dimenzioni parametri značajno smanjeni samo u jednom pravcu. Određivanje koeficijenta toplotne provodnosti je vršeno određivanjem koeficijenta difuzije fonona, fononske specifične toplote i masene gustine za datu strukturu. Koeficijent difuzije je naen metodom Grinovih funkcija, korišćenjem Kubo formule. Izvršena su poređenja redukovanih toplotnih provodnosti filma i neprekidnih (balk) struktura za širi temperaturski interval. U poslednjem delu je analiziran uticaj promena na granicama na toplotnu provodnost

Fononska toplotna provodnost tankih kristalnih filmova

In this paper we have analyzed phonon thermal conductivity of thin crystalline films, i.e. of low-dimensional structures with dimensional parameters significantly decreased in only one direction. Finding of coefficient of thermal conductivity is achieved by deriving phonon coefficient of diffusion, phonon specific heat and specific density for explored structure. Coefficient of diffusion is derived by applying method of Green functions, using Kubo formula. Then reduced thermal conductivities for film and bulk structures were compared for wider temperature interval. In the last section an influence of changes of heat conductivity on the boundaries is analyzed.U radu je analizirana fononska toplotna provodnost u kristalnim filmovima, tj. niskodimenzionim strukturama kod kojih su dimenzioni parametri značajno smanjeni samo u jednom pravcu. Određivanje koeficijenta toplotne provodnosti je vršeno određivanjem koeficijenta difuzije fonona, fononske specifične toplote i masene gustine za datu strukturu. Koeficijent difuzije je naen metodom Grinovih funkcija, korišćenjem Kubo formule. Izvršena su poređenja redukovanih toplotnih provodnosti filma i neprekidnih (balk) struktura za širi temperaturski interval. U poslednjem delu je analiziran uticaj promena na granicama na toplotnu provodnost