Learning Conditional Deformable Templates with Convolutional Networks

We develop a learning framework for building deformable templates, which play a fundamental role in many image analysis and computational anatomy tasks. Conventional methods for template creation and image alignment to the template have undergone decades of rich technical development. In these frameworks, templates are constructed using an iterative process of template estimation and alignment, which is often computationally very expensive. Due in part to this shortcoming, most methods compute a single template for the entire population of images, or a few templates for specific sub-groups of the data. In this work, we present a probabilistic model and efficient learning strategy that yields either universal or conditional templates, jointly with a neural network that provides efficient alignment of the images to these templates. We demonstrate the usefulness of this method on a variety of domains, with a special focus on neuroimaging. This is particularly useful for clinical applications where a pre-existing template does not exist, or creating a new one with traditional methods can be prohibitively expensive. Our code and atlases are available online as part of the VoxelMorph library at http://voxelmorph.csail.mit.edu.Comment: NeurIPS 2019: Neural Information Processing Systems. Keywords: deformable templates, conditional atlases, diffeomorphic image registration, probabilistic models, neuroimagin

The Effect of Multiple Transverse Modes in Self-Mixing Sensors Based on Vertical-Cavity Surface-Emitting Lasers

In this work we investigate the effect of multiple transverse modes, such as those found in Vertical-Cavity Surface-Emitting Lasers, in self-mixing sensors. We show that the sensitivity of the system and the accuracy of the measurement changes periodically with target distance

A Massively Parallel Imaging System Based on the Self-Mixing Effect in a Vertical-Cavity Surface-Emitting Laser Array

In this work we propose a massively parallel self-mixing imaging system, based on an array of VCSELs, to measure surface profiles of displacement, distance, velocity and liquid flow rate. The feasibility of this concept is demonstrated by the successful operation of a small scale prototype consisting of eight individual commercial VCSELs with integrated photodetectors. The system is used to accurately measure the velocity at different radial points on a rotating disk. The results show no influence of crosstalk. A massive version of the system will be useful in many industrial and biomedical applications where real-time surface profiling, vibrometry and velocimetry will be very beneficial

Reparatory and Manufacturing Hard-Facing of Working Parts Made of Stainless Steels in Confectionary Industry

In this paper, for the sake of improving the reparatory hard-facing technology is especially analyzed reparatory hard-facing of tools for manufacturing compressed products in confectionary industry. Those products are being made of a mixture consisting of several powdery components, which is compressed under high pressure. In that way the connection between particles is realized, thus achieving certain hardness and strength of the confectionary product. The considered tool is made of high-alloyed stainless steel. The tool contains 30 identical working places. Besides the production process wear, on those tools, from time to time, appear mechanical damage on some of the products' shape punches, as cracks at the edges, where the products' final shapes are formed. Those damages are small, size wise, but they cause strong effect on the products' final shape. The aggravating circumstance is that the shape punch is extremely loaded in pressure, thus after the reparatory hard-facing, the additional heat treatment is necessary. Mechanical properties in the heat affected zone (HAZ) are being leveled by annealing and what also partially reduces the residual internal stresses

Experimental Demonstration of Signal-to-Noise-Ratio Improvement of Fourier-Domain Optical Coherence Tomography

A recent advance in optical coherence tomography (OCT), termed swept-source OCT, is generalized into a new technique, Fourier-domain OCT. It represents a realization of a full-field OCT system in place of the conventional serial image acquisition in transverse directions typically implemented in "flying-spot" mode. To realize the full-field image acquisition, a Fourier holography system illuminated with a swept-source is employed instead of a Michelson interferometer commonly used in OCT. Fourier-domain OCT offers a new leap in signal-to-noise ratio improvement, as compared to flying-spot OCT systems. This paper presents experimental evidence that the signal-to-noise ratio of this new technique is indeed improved.Comment: submitted to Optics Letters 7/14/200

Signal-to-signal-to-noise ratio of full-field Fourier domain optical coherence tomography: experiment

We report a new approach in optical coherence tomography (OCT) termed full-field Fourier-domain OCT (3F-OCT). A three-dimensional image of a sample is obtained by digital reconstruction of a three-dimensional data cube, acquired using a Fourier holography recording system illuminated with a swept-source. This paper presents theoretical and experimental study of the signal-to-noise ratio of the full-field approach versus serial image acquisition approach, represented by 3F-OCT and "flying-spot" OCT systems, respectively

Magnetostratigraphic, biostratigraphic, and stable isotope stratigraphy of an Upper Miocene drill core from the Salé Briqueterie (northwestern Morocco):...

We report a high-resolution stable isotope, carbonate, magnetostratigraphic, and biostratigraphic record from a 175-m drill core from the Salé Briqueterie, which is part of the Bou Regreg section in northwestern Morocco. The Salé drill core spans the interval from paleomagnetic Chron C4n partim to C3r (earliest Gilbert), which represents the time leading up to and including the isolation and desiccation of the Mediterranean (i.e., the Messinian salinity crisis). During Chrons C3An and C3Ar (6.935 to 5.894 Ma) the isotope and carbonate signals display quasi-periodic variations with estimated periods of 40 and 100 kyr, respectively. We interpret the 40-kyr δ^18O variations as reflecting changes in global ice volume caused by obliquity-induced changes (41 kyr) in solar insolation in polar regions. The 100-kyr carbonate variations probably represent long-term modulation of the amplitude of the precessional cycle (~21 kyr), which is not resolved by our sampling frequency. The cyclic nature of the oxygen isotope signal permits us to extend the isotope nomenclature of Shackleton et al. (1994a) from stage TG24 in Chron C3r (earliest Gilbert) to stage C3Ar.δ^18O.18 at the base of Chron C3Ar (6.935 Ma). A major change in paleoceanographic conditions is recorded across the Tortonian/Messinian boundary, which we correlate to Chron C3Bn at 7.04 Ma. Benthic foraminiferal δ^18O values increased by an average of 0.4‰ in two steps at 7.17 Ma and 6.8 Ma and δ^13C values decreased by 0.7-0.8‰ between 7.1 and 6.8 Ma, representing the late Miocene carbon shift. The first step in δ^18O values coincides with an inferred reversal in deep water circulation through the Rifian Corridor, and the second correlates with the base of the Tripoli Formation and onset of "crisis conditions" in the Mediterranean. We suggest that the increase in δ^18O values represents, at least in part, an increase in global ice volume that lowered sea level and contributed to the establishment of a negative water budget in the Mediterranean. Average δ^18O values remained high throughout most of Chrons C3Ar and C3An, reaching maximum δ^18O values during isotope stages TG20 and 22 in Chron C3r (earliest Gilbert). The glacio-eustatic falls associated with these events may have resulted in the complete isolation of the Mediterranean from the world ocean (Shackleton et al., 1994a). Following stage TG12 in the Salé record, there exists a trend toward progressively lower δ^18O values that may represent a series of marine transgressions that eventually reflooded the Mediterranean and ended the Salinity Crisis

Diversity of Cortical Interneurons in Primates: The Role of the Dorsal Proliferative Niche

Summary Evolutionary elaboration of tissues starts with changes in the genome and location of the stem cells. For example, GABAergic interneurons of the mammalian neocortex are generated in the ventral telencephalon and migrate tangentially to the neocortex, in contrast to the projection neurons originating in the ventricular/subventricular zone (VZ/SVZ) of the dorsal telencephalon. In human and nonhuman primates, evidence suggests that an additional subset of neocortical GABAergic interneurons is generated in the cortical VZ and a proliferative niche, the outer SVZ. The origin, magnitude, and significance of this species-specific difference are not known. We use a battery of assays applicable to the human, monkey, and mouse organotypic cultures and supravital tissue to identify neuronal progenitors in the cortical VZ/SVZ niche that produce a subset of GABAergic interneurons. Our findings suggest that these progenitors constitute an evolutionary novelty contributing to the elaboration of higher cognitive functions in primates