Microwave assisted rapid and efficient synthesis of new 3-ethoxy-4,6-diaryl-4,5-dihydro-2,1-benzisoxazoles

749-753A simple, extremely fast and efficient synthesis of new 3-ethoxy-4,6-diaryl-4,5-dihydro2,1-benzisoxazoles has been achie­ved under microwave irradiation

An efficient one-pot synthesis of isoxazolyl polyhydroquinolines <i style="">via</i> Hantzsch condensation using L-proline as catalyst

751-755L-Proline is employed as an efficient organo catalyst for the one-pot, four component Hantzsch reaction for the synthesis of isoxazolyl polyhydroquinoline derivatives. This method is environmentally benign, affords excellent yields and has operational simplicity and isoxazole amines are used for the first time in this synthesis

Synthesis of isoxazolyl quinoline-3-carboxamides and 1,4-benzothiazine-2-carboxamides as potential bioactive compounds

1144-1150Synthesis of isoxazolyl quinoline-3-carboxamides 3 and isoxazolyl-1,4-benzothiazine-2-carboxamides 4 have been accompli­shed by cyclocondensation of isoxazolyl-3-oxo-butanamides 2 with o-amino benzaldehyde or o-amino thiophenol involving Friedelander’s condensation and oxidative cyclization respectively

Synthesis and antimicrobial activity of 1-(5-methyl-3-isoxazolyl)-3,6-diaryl-4-thioxo-1,3,5-triazinan-2-ones

223-228Treatment of 3-benzalamino-5-methylisoxazoles 1 with ammonium thiocyanate in hot acetic acid affords the corresponding N-isothiocyanato(phenyl)methyl-N-(5-methyl-3-isoxazolyl)amines 2a-j in excellent yields. N-Isoxazolyl-α-aminoisothiocyanates 2a-j on reaction with aryl isocyanates undergoes cyclization to give the corresponding isoxazolyl-4-thioxo-1,3,5-triazinan-2-ones 3a-l in good yields. The compounds 2a-j and 3a-l have been screened for their antimicrobial activity

ChemInform Abstract: Synthesis of Isoxazolyl Quinoline-3-carboxamides and 1,4-Benzothiazine-2-carboxamides as Potential Bioactive Compounds.

1144-1150Synthesis of isoxazolyl quinoline-3-carboxamides 3 and isoxazolyl-1,4-benzothiazine-2-carboxamides 4 have been accompli­shed by cyclocondensation of isoxazolyl-3-oxo-butanamides 2 with o-amino benzaldehyde or o-amino thiophenol involving Friedelander’s condensation and oxidative cyclization respectively

An elegant one-pot synthesis of isoxazolo[2,3-<img src='/image/spc_char/alpha.gif' border=0> ]pyrimidines

1422-1427An elegant one-pot synthesis of isoxazolo[2,3– ]pyrimidines has been achieved by reaction of 3-amino-5-methylisoxazole with 4-arylidene-2-phenyl-5-oxazolones. Treatment of 3-amino-5-methylisoxazole with chalcones also resulted in the formation of isoxazolo[2,3- ]pyrimidines in a single step. The structure of the products have been elucidated by spectral and analytical data

Synthesis of <i style="">N-</i>1-(3,5-dimethyl-4-isoxozolyl)-3-(4-aryl-5-thioxo-4,5-dihydro-1-<i style="">H</i>–1, 2, 4-triazol–3-yl)propanamides as possible antitumor agents

1667-1670Synthesis of N-1 (3, 5-dimethyl-4-isoxazolyl)-3-(4-aryl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-propanamides 7 have been accomplished from 4-amino-3,5-dimethylisoxazole 1 in five steps. The structural elucidation of the synthesized compounds has been performed by IR, 1H NMR and mass spectroscopic data besides elemental analyses

Synthesis and antimicrobial activity of novel spiro-isoxazolyl oxazolidin-4-one-[5,5¹]-1,2,4-oxadiazolines and thiazolidin-4-one-[5,5¹]-1,2,4-oxadiazolines

1800-1806The synthesis of novel isoxazolyl 1,6-dioxa-2,4,9-triazaspiro[5,51]-non-2-ene-8-ones 4 and isoxazolyl 1-oxa-6-thia-2,4,9-triazaspiro[5,51]-non-2-ene-8-ones 6 analogs is described. Reaction of N-1-(3,5-dimethyl-4-isoxazolyl)-2-chloroacetamide 2 with arylisocyanates yields 3-(3,5-dimethyl-4-isoxazolyl)-2-arylimino-1,3-oxazolan-4-ones 3. Cycloaddition of 3 with benzonitrile oxides furnishes novel spiro isoxazolyl oxazolidin-4-one[5,51]-1,2,4-oxadiazolines 4. Reaction of <b style="mso-bidi-font-weight: normal">2 with arylisothiocyanates affords 3-(3,5-dimethyl-4-isoxazolyl)-2-arylimino-1,3-thiazolan-4ones 5. Cycloaddition of<b style="mso-bidi-font-weight: normal"> 5 with benzonitrile oxides yields novel spiro isoxazolyl thiazolidin-4-one[5,51]-1,2,4-oxadiazolines <b style="mso-bidi-font-weight: normal">6. All the new products have been characterized by elemental analyses, IR, 1H&nbsp;NMR and mass spectral studies. Compounds 4 and<b style="mso-bidi-font-weight: normal"> 6 have been screened for their antimicrobial activity