127 research outputs found
Myocardial T1 mapping as a diagnostic tool in pediatric patients with a concern for cardiac disease
Effect of spatial bias on the nonequilibrium phase transition in a system of coagulating and fragmenting particles
We examine the effect of spatial bias on a nonequilibrium system in which
masses on a lattice evolve through the elementary moves of diffusion,
coagulation and fragmentation. When there is no preferred directionality in the
motion of the masses, the model is known to exhibit a nonequilibrium phase
transition between two different types of steady states, in all dimensions. We
show analytically that introducing a preferred direction in the motion of the
masses inhibits the occurrence of the phase transition in one dimension, in the
thermodynamic limit. A finite size system, however, continues to show a
signature of the original transition, and we characterize the finite size
scaling implications of this. Our analysis is supported by numerical
simulations. In two dimensions, bias is shown to be irrelevant.Comment: 7 pages, 7 figures, revte
Pulmonary artery resuscitation for isolated ductal origin of a pulmonary artery
ObjectiveDuctal origin of a pulmonary artery (DOPA) is commonly misdiagnosed as agenesis of a pulmonary artery (PA), which may result in inadequate treatment. The objective is to describe the results of resuscitation of unilateral DOPA.MethodsThis study is a retrospective review of all patients with unilateral DOPA who underwent PA resuscitation at Texas Children's Hospital from 1993 to 2012. Patients with other cardiac or contralateral lung anomalies were excluded.ResultsTen patients, median age 2 years (range, 3 days to 9 years), with unilateral DOPA were included. Symptoms were present in 6 patients. Cardiac catheterization was performed in all and showed a patent duct or a ductal stump in most patients and a small PA on wedge angiography of the pulmonary veins. Two patients underwent single-stage centralization. The other 8 underwent ductal stenting (n = 2) or a systemic-to-PA shunt (n = 6) as the first stage before centralization. The 2 patients with ductal stenting developed pulmonary edema. The 2 patients with a cryopreserved vein shunt developed early thrombosis requiring reintervention. Nine patients have undergone centralization. Six patients have required further interventional procedures. There have been no deaths. Symptoms and lung hypoplasia have improved in all patients. Median relative lung perfusion at follow-up was 26% (range, 12%-46%) with significant improvement in the size of the affected PA.ConclusionsPA resuscitation is effective at restoring flow to the affected lung resulting in improved diameter of the PA, lung growth, and resolution of symptoms. PA resuscitation should be considered in all children with DOPA, including those beyond infancy
Large-scale exome datasets reveal a new class of adaptor-related protein complex 2 sigma subunit (AP2 sigma) mutations, located at the interface with the AP2 alpha subunit, that impair calcium-sensing receptor signalling
Persistence properties of a system of coagulating and annihilating random walkers
We study a d-dimensional system of diffusing particles that on contact either
annihilate with probability 1/(q-1) or coagulate with probability (q-2)/(q-1).
In 1-dimension, the system models the zero temperature Glauber dynamics of
domain walls in the q-state Potts model. We calculate P(m,t), the probability
that a randomly chosen lattice site contains a particle whose ancestors have
undergone exactly (m-1) coagulations. Using perturbative renormalization group
analysis for d < 2, we show that, if the number of coagulations m is much less
than the typical number M(t), then P(m,t) ~ m^(z/d) t^(-theta), with theta=d Q
+ Q(Q-1/2) epsilon + O(epsilon^2), z=(2Q-1) epsilon + (2 Q-1) (Q-1)(1/2+A Q)
epsilon^2 +O(epsilon^3), where Q=(q-1)/q, epsilon =2-d and A =-0.006. M(t) is
shown to scale as t^(d/2-delta), where delta = d (1 -Q)+(Q-1)(Q-1/2) epsilon+
O(epsilon^2). In two dimensions, we show that P(m,t) ~ ln(t)^(Q(3-2Q))
ln(m)^((2Q-1)^2) t^(-2Q) for m << t^(2 Q-1). The 1-dimensional results
corresponding to epsilon=1 are compared with results from Monte Carlo
simulations.Comment: 12 pages, revtex, 5 figure
Kang-Redner Anomaly in Cluster-Cluster Aggregation
The large time, small mass, asymptotic behavior of the average mass
distribution \pb is studied in a -dimensional system of diffusing
aggregating particles for . By means of both a renormalization
group computation as well as a direct re-summation of leading terms in the
small reaction-rate expansion of the average mass distribution, it is shown
that \pb \sim \frac{1}{t^d} (\frac{m^{1/d}}{\sqrt{t}})^{e_{KR}} for , where and . In two
dimensions, it is shown that \pb \sim \frac{\ln(m) \ln(t)}{t^2} for . Numerical simulations in two dimensions supporting the analytical
results are also presented.Comment: 11 pages, 6 figures, Revtex
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