Formulation and Evaluation of Atenolol Pulsatile Press Coated Tablets Using Rupturable and Erodible Polymers

Pulsatile systems are best for the drugs, which follows chronopharmacological behaviour where night time dosing is required, drugs having high first-pass effect and having specific site of absorption in GIT. In this study, colon targeted pulsatile release tablets of atenolol was prepared using press coating technique to treat hypertension in the early hours of the morning. Pulsatile release of atenlol was achieved by press coating of atenolol core tablet using combination of rupturable and erodible polymers. Mixtures different weight ratio of HPMC K4M and EC (150:00, 125:25, 100:50, 75:75, 50:100, 25:125, 00:150) were press coated over atenolol core tablets to release atenolol after a desired lag time of about 6– 6.5 hr. Formulations HE4 (75:75) and HE5 (50:100) compression coated tablets achieve a burst release of atenolol after 6.5 hr and 6 hr lag time respectively, which is applicable pulsatile drug delivery of atenolol for hypertension

FORMULATION OF FUROSEMIDE SOLID DISPERSION WITH MICRO CRYSTALLINE CELLULOSE FOR ACHIEVE RAPID DISSOLUTION

Furosemide, a weekly acidic, loop diuretic drug indicated for treatment of edema and hypertension having high permeability through stomach. It is practically insoluble in gastric fluid (0.006 mg/ mL) and having highly permeability through stomach but due to its solubility limitation it can’t enter into systemic circulation. It was logically decided to design experiment, so as to achieve the set objectives. Attempt was made to prepare solid dispersion of furosemide with Poly ethylene glycol (PEG) 6000 containing microcrystalline cellulose (MCC) as adsorbent which would dissolve completely in less than 30 minutes (target selected by considering minimum gastric empting time). Microcrystalline cellulose converted sticky dispersion in to free flow powder hence increase surface area which responsible for dissolution improvement. Factorial design was applied to optimize formulation. Amount of poly ethylene glycol 6000 and microcrystalline cellulose were selected as an Independent variable while angle of repose and T100% were selected as dependent variable. Attempts for dissolution rate of furosemide improve bioavailability and consequently dose reduction would possible