Synthesis of Isoquinoline Derivatives from β-Hydroxyarylethanamides

<div><p></p><p>A simple and efficient protocol for the construction of medicinally important substituted isoquinolines through intramolecular cyclization of β-hydroxyarylethanamides using acetic anhydride and phosphorous pentoxide in dioxane has been described. The chemo- and regioselectivities due to the influence of different catalysts were investigated and optimized for good to excellent yields. All the synthesized compounds have been characterized by NMR and mass spectral analyses.</p></div

SnCl₂-Catalyzed Selective Atom Economic Imino Diels–Alder Reaction: Synthesis of 2-(1<i>H</i>-Pyrrolo[2,3-<i>b</i>]pyridin-3-yl)quinolines

The synthesis of 2-(1<i>H</i>-pyrrolo­[2,3-<i>b</i>]­pyridin-3-yl)­quinolines by a SnCl₂-catalyzed multicomponent reaction has been described. The reaction proceeds chemo- and regioselectively in an atom-economic way, generating a library of 24 quinoline derivatives

Erbium Triflate Promoted Multicomponent Synthesis of Highly Substituted Imidazoles

The synthesis of highly substituted imidazole derivatives has been achieved from various α-azido chalcones, aryl aldehydes, and anilines. This multicomponent protocol employs erbium triflate as a catalyst resulting in excellent yield of the imidazoles