Risk Factors for Bladder Cancer: Results of a Survey of Hospital Patients

Introduction: Several risk factors have been identified in the occurrence of bladder cancer. These include genetic and hereditary factors, smoking and tobacco use, increased body mass index, occupational exposure to certain chemicals and dyes, medical conditions such as chronic cystitis and infectious diseases such as schistosomiasis. This study aimed to evaluate risk factors in patients with bladder cancer. Materials and Methods: All patients presenting to the uro-oncology department of the hospital with imaging and histology confirmed bladder cancer were included in the study. Age- and gender-matched patients presenting to the department of urology with benign disorders were prospectively included as controls. All the study subjects and the controls completed a self-administered structured questionnaire. Results: Seventy-two (67.3%) of the participants with bladder cancer were males. The mean age of participants with bladder cancer was 59.24 ± 16.28 years. Most participants with bladder cancer worked as farmers (35.5%) or industrial workers (24.3%). Recent history of recurrent urinary tract infections was seen in 85 (79.4%) of the participants with bladder cancer and 32 (30.8%) of controls. Diabetes mellitus was more common among participants with bladder cancer. A significant number of participants with bladder cancer used tobacco and smoked compared to controls. Conclusions: This study highlights numerous potential biological and epidemiological factors that may act as a risk factors for bladder cancer. These factors could explain the gender differences observed in the incidence of bladder cancer. In addition, the study indicates the intense

Enhancing Prostate Cancer Diagnosis with Deep Learning: A Study using mpMRI Segmentation and Classification

Prostate cancer (PCa) is a severe disease among men globally. It is important to identify PCa early and make a precise diagnosis for effective treatment. For PCa diagnosis, Multi-parametric magnetic resonance imaging (mpMRI) emerged as an invaluable imaging modality that offers a precise anatomical view of the prostate gland and its tissue structure. Deep learning (DL) models can enhance existing clinical systems and improve patient care by locating regions of interest for physicians. Recently, DL techniques have been employed to develop a pipeline for segmenting and classifying different cancer types. These studies show that DL can be used to increase diagnostic precision and give objective results without variability. This work uses well-known DL models for the classification and segmentation of mpMRI images to detect PCa. Our implementation involves four pipelines; Semantic DeepSegNet with ResNet50, DeepSegNet with recurrent neural network (RNN), U-Net with RNN, and U-Net with a long short-term memory (LSTM). Each segmentation model is paired with a different classifier to evaluate the performance using different metrics. The results of our experiments show that the pipeline that uses the combination of U-Net and the LSTM model outperforms all other combinations, excelling in both segmentation and classification tasks.Comment: Accepted at CISCON-202

Primitive Neuroectodermal Tumor (PNET) of the Kidney with Level IV Inferior Vena Caval Thrombus: A Case Report

Primitive neuroectodermal tumor (PNET) is classified as a malignant tumor of the kidney. It was first recognized by Arthur Purdy Stout in 1918, as a member of the family of “small round-cell tumorsâ€. Primitive renal localization is very rare. We report a case of Primitive neuroectodermal tumor of the kidney with level IV inferior vena caval (IVC) thrombus. Histologically, the tumor consisted of small round cells with round nuclei and scant cytoplasm

Antenatally diagnosed upper moiety hydronephrosis in a child with ectopic ureter: A case report

An ectopic ureter is any ureter, single or duplex, that does not enter the trigonal area of the bladder. In a duplex system, the ectopic ureter is inevitably the upper pole ureter. In males, the ectopic ureter always enters the urogenital system above the external sphincter. The majority of ectopic ureters are detected through prenatal ultrasound imaging, even if the specific diagnosis is not made until after birth. Radionuclide renal imaging remains the gold standard for renal functional assessment, and this is usually best provided by dimercaptosuccinic acid imaging. The goals of therapy are the preservation of renal function; elimination of infection, obstruction, and reflux; and maintenance of urinary continence. We report a case of a 6-month-old male child presenting with urinary tract infection. The child was diagnosed to have had a cystic dilatation of the right upper moiety on antenatal ultrasonography imaging

Augmentation gastrocystoplasty in a child with orofacial syndrome and dysfunctional voiding

We report the case of a child diagnosed with orofacial syndrome with dysfunctional voiding and elevated serum creatinine in whom augmentation gastrocystoplasty was performed to manage urinary incontinence.Keywords: augmentation gastrocystoplasty, dysfunctional voiding, orofacial syndrom

An unusual presentation of anterior urethral valve in a child with diabetes mellitus

Anterior urethral valve (AUV) is identified to be a common source of congenital obstructive lesion of the anterior urethra. Up to 80% of children with AUVs develop bladder dysfunction, bladder instability, hyperreflexia, diminished compliance and capacity. We report a case of an unusual presentation of a child with AUV and diabetes mellitus

Reproductive Toxicology: An Update

Human reproduction and development is a succession of symbiotic events. Nearly, at every point of this phenomenon found to be the principle target of one or more reproductive toxicants. Chemical agents, physical factors, as well as biological intruders can pose antagonistic effects on reproductive potential of an organism. The pathways are different viz., either damaging embryo and sometimes fetus or inducing mutation in a parent’s germ cell. The outcomes are declined fertility to impulsive abortion, functional discrepancies, developmental retardation, structural anomalies, etc. It is a now essential to establishing proper databases for reproductive and developmental toxicity chemicals, physical and biological factors including appropriate awareness among the society. Although many in vitro and in vivo toxicology studies are in pipeline which are independent studies but combination with other hazardous studies could give us an accurate numbers

Management of antenatally diagnosed hydronephrosis in a child presenting later with urinary tract infections: A case report

Preservation of renal function remains the main goal of follow-up of a child with antenatal hydronephrosis. The question remains as to how long we need to follow these children. Even after several decades, the indications and timing of surgery in a newborn with hydronephrosis are still debated. Herewith, we report the case of a 9-year-old male child who was diagnosed to have hydronephrosis on antenatal scans and was managed conservatively postnatally who presented after 9 years with recurrent urinary tract infections

Therapeutic Applications of Monoclonal Antibodies in Urologic-Oncology Management - An Update

The idea of utilizing immunotherapy for the treatment of cancers has been appealing to scientists and clinicians for over a several decades. Immunotherapy for cancers encompasses knowledge gained from a wide range of disciplines and has the potential to procure the ‘magic bullet’ for the treatment of cancer. Monoclonal antibody-based treatment of cancer has been recognized as one of the most successful therapeutic strategies for both hematologic malignancies and solid tumours in the last 20 years. The discovery of hybridoma technology in late 1975 and the development of chimeric, humanized, and human antibodies have increased the availability and utility of immunotherapy for the treatment of cancer. Metastatic or recurrent cancer continues to be the bane of the urological oncologist. Despite recent improvements in therapeutic management and outcomes for clinically localized disease overall survival rate in patients with the majority of metastatic and recurrent genitourinary malignancies remains relatively unchanged. By targeting tumours through specific or associated antigens, it is possible to selectively eliminate tumour cells and maintain an acceptable toxicity profile. Therapeutic antibodies that target immune cells are also being developed with the goal of breaking local tolerance and stimulating the patient’s anti-tumor immune response. As with other treatment modalities, immunotherapy is far from perfect and requires additional study to optimize clinical response and overcome therapeutic resistance. Modern advances in the field of immunotherapy hold the promise of providing the clinical urologist/oncologist with new tools to fight urological cancer. However, the literature on monoclonal antibody-based immunotherapy with a particular emphasis on target antigens, monoclonal antibody design and potential applications in the field of urology is limited. Hence, the present chapter focuses on the applications of Immunotherapy using monoclonal antibodies for urologic oncology settings such as prostate, bladder, renal, testicular and penile with a hope to highlight its clinical efficacy and also its mechanisms of action in each of these cancer types

Diagnosis of Oral Cancers by Targeting VPAC Receptors: Preliminary Report

Introduction: Oral cancer is a major health problem. The study of exfoliative cytology material helps in the differentiation of premalignant and malignant alterations of oral lesions. The objective of this study was to assess the feasibility of detecting oral cancer by targeting genomic VPAC (combined vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide) receptors expressed on malignant oral cancer cells. Patients & methods: All patients with suspected oral cavity cancers/lesions formed the study group. The samples from the oral cavity lesion or suspicious area were collected with a cytology brush. The harvested material was examined for malignant cells by 1. the standard PAP stain and 2. targeting the VPAC receptors on the cell surface using a fluorescent microscope. Similarly, malignant cells were identified from cells shed in oral gargles. Results: A total of 60 patients with oral lesions were included in the study. The histopathological diagnosis was squamous cell carcinoma in 30 of these. The VPAC receptor positivity both on the brush cytology staining as well oral gargle staining was more sensitive than the brush cytology PAP staining. The accuracy of the various techniques was as follows, brush cytology PAP staining at 86.67%, brush cytology VPAC staining at 91.67% and oral gargle VPAC staining at 95%. Conclusions: This preliminary study validates our belief that malignant cells in the saliva can be identified by targeting the VPAC receptors. The test is simple, easy, non-invasive and reliable in the detection of oral cancers