24 research outputs found
An overview of physico-chemical mechanisms of biogas production by microbial communities: a step towards sustainable waste management
Hypoglycemic Effects of Clitoria ternatea Linn. (Fabaceae) in Alloxan-induced Diabetes in Rats
Purpose: This study aims to investigate the therapeutic effects of
the aqueous extract of Clitoria ternatea Linn. Fabaceae leaves and
flowers on alloxan-induced diabetes in rats. Methods: The effect of
orally administered aqueous extracts (400 mg/kg body weight) of
Clitoria ternatea leaves and flowers on serum glucose, glycosylated
hemoglobin, and insulin were examined in control and extract-treated
diabetic rats. The glycogen content of the liver and skeletal muscles
of the rats was evaluated while the activities of the glycolytic
enzyme, glucokinase, and the gluconeogenic enzyme,
glucose-6-phosphatase in the liver were assessed. The extracts were
administered over a period of 84 days. Results: The aqueous extracts
of Clitoria ternatea leaves and flowers significantly (P<0.05)
reduced serum glucose, glycosylated hemoglobin and the activities of
gluconeogenic enzyme, glucose-6- phosphatase, but increased serum
insulin, liver and skeletal muscle glycogen and the activity of the
glycolytic enzyme, glucokinase. For all the biochemical tests
performed, the leaf extract-treated rat showed essentially the same
profile as those treated with the flower extract. Conclusion: The
present investigation suggests that Clitoria ternatea leaf and flower
extracts exhibit antihyperglycaemic effect in rats with alloxan-induced
diabetes mellitus