Acute toxicity bioassay of the mercury chloride and copper Sulphate in Rutilus caspicus and Rutilus kutum

The purpose of the present study was to determine the acute toxicity (LC50) of HgCl2 and CuSO4 in Caspian roach (Rutilus caspicus) and CuSO4 in Caspian kutum (Rutilus kutum). The Caspian roach LC50 values for HgCl2 at 24, 48, 72, and 96-hrs of exposure, were 0.64, 0.61, 0.42, and 0.28 mg L-1, respectively, and for CuSO4 were 11.55, 5.08, 2.49, and 1.47 mg L-1, respectively. The Caspian roach LC50 values for CuSO4 at 24, 48, 72, and 96-hrs of exposure, were 5.31, 4.17, 3.20, and 2.25 mg L-1, respectively. The results of this study showed that the toxicity of HgCl2 is higher than that of CuSO4 for the studied species. The mortality decreased with time, and most of the deaths were occurred during the first 24 hrs

Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat

Objective: The purpose of the present study was to examine whether Rheum ribes extract prevents cisplatin-induced nephrotoxicity. Materials and Methods: The animals were divided into three groups: Group A considered as control group, group B were treated with cisplatin (3 mg/kg B.W. for 3 alternative days), and group C further to cisplatin received the aqueous extract of Rheum ribes (150 mg/rat). Results: Blood urea nitrogen (BUN) level increased in group B on days 14 and 42 compared to day 0 ( P < 0.001); it was also increased in group B vs. group A on day 14 ( P < 0.001). Rheum ribes extract decreased the serum BUN level on day 14 compared to group B ( P < 0.001). Serum creatinine level in group B had a similar profile as serum BUN level but Rheum ribes had no effect on blood creatinine level. Serum cholesterol level was increased in group B on days 14 and 42 compared to day 0 ( P < 0.001). Also, cholesterol level was significantly increased in group B when compared to group A on day 14 ( P < 0.001). Rheum ribes decreased the blood cholesterol level on day 42 in comparison to group B ( P < 0.001). Serum glucose level was increased in group B on days 14 and 42 vs. day 0 ( P < 0.001). Also, glucose level was significantly increased in group B when compared to group A on day 42 ( P < 0.001). Rheum ribes increased the serum glucose level on days 14 and 42 compared to day 0 ( P < 0.05). Histology of kidneys exposed to cisplatin showed renal injury, but Rheum ribes had no effect on the kidney architecture. Conclusion: Cisplatin-induced nephrotoxicity was confirmed in our study. Although Rheum ribes had some effects on biochemical parameters; its effect on renal histology in injured kidney was insignificant