Part I. Dibenzcycloheptatrienes. Part 2. A New Molecular Rearrangement Effected by Aluminium Chloride

A: Dibenzcycloheptatrienes. 2:3-Dimethoxy-9-and -10-mefhylphenanthrenes were synthesised and, by expansion of the central ring in each, were converted into dihenzocycloheptatrienones. Thereby 13:14-dimethoxy-3:4-5:6-dihenzocyclohepta-1:3:5-triene was isolated and fully characterised hut the isomeric triene was less well defined and attempted interconversion of the two gave results which were not free of ambiguity. B: A New Molecular Rearrangement effected by Aluminium Chloride. It is shown that through being heated with aluminium chloride chromanone is rearranged to 7-hydroxyindanone and dihydrocoumarin to 4-hydroxyindanone. Further applications of this type of rearrangement are described and discussed. In particular it is employed to prepare 6-hydroxyperinaphthen-7-one, the corresponding 8:9-dihydride and 6-hydroxy-perinaphthen-9-one. A comparative study of these three compounds is made to evaluate the chemical effects which are associated with the strong hydrogen-bonding present in the first of them. An improved method for the synthesis of chromanones has been developed

Multi Aspect Based Document Level Sentiment Analysis for Educational Institute Analysis

ABSTRACT: Sentiment Analysis is used to determine the attitude of a writer with respect to some topic or the overall contextual polarity of a document. The objective of our project is to build an interactive portal wherein the comparative analysis of various colleges can be visualized. In doing so ,instead of the basic factual information, analysis will be done based on the feedback and reviews acquired from various sources. In this approach , document level sentiment analysis will be done considering every aspect of the same using the techniques of natural language processing

Endothelial Nitric Oxide Synthase is Regulated by ERK Phosphorylation at Ser602

eNOS (endothelial nitric oxide synthase) contains a MAPK (mitogen-activated protein kinase)-binding site associated with a major eNOS control element. Purified ERK (extracellular-signal-regulated kinase) phosphorylates eNOS with a stoichiometry of 2–3 phosphates per eNOS monomer. Phosphorylation decreases NO synthesis and cytochrome c reductase activity. Three sites of phosphorylation were detected by MS. All sites matched the SP and TP MAPK (mitogen-activated protein kinase) phosphorylation motif. Ser602 lies at the N-terminal edge of the 42-residue eNOS AI (autoinhibitory) element. The pentabasic MAPK-binding site lies at the opposite end of the AI, and other critical regulatory features are between them. Thr46 and Ser58 are located in a flexible region associated with the N terminus of the oxygenase domain. In contrast with PKC (protein kinase C), phosphorylation by ERK did not significantly interfere with CaM (calmodulin) binding as analysed by optical biosensing. Instead, ERK phosphorylation favours a state in which FMN and FAD are in close association and prevents conformational changes that expose reduced FMN to acceptors. The close associations between control sites in a few regions of the molecule suggest that control of signal generation is modulated by multiple inputs interacting directly on the surface of eNOS via overlapping binding domains and tightly grouped targets

CB1 cannabinoid receptor-mediated modulation of food intake in mice

Read the full text ePDF PDF ePDFPDF PDF Tools Share Abstract 1 Marijuana's appetite‐increasing effects have long been known. Recent research suggests that the CB1 cannabinoid receptor antagonist SR141716A may suppress appetite. This study represents a further, systematic investigation of the role of CB1 cannabinoid receptors in the pharmacological effects of cannabinoids on food intake. 2 Mice were food‐restricted for 24 h and then allowed access to their regular rodent chow for 1 h. Whereas the CB1 antagonist SR141716A dose‐dependently decreased food consumption at doses that did not affect motor activity, Δ9‐tetrahydrocannabinol (Δ9‐THC) increased food consumption at doses that had no effect on motor activity. O‐3259 and O‐3257, structural analogs of SR141716A, produced effects similar to those of the parent compound. 3 Amphetamine (a known anorectic) and diazepam (a benzodiazepine and CNS depressant) decreased food consumption, but only at doses that also increased or decreased motor activity, respectively. The CB2 cannabinoid receptor antagonist SR144528 and the nonpsychoactive cannabinoid cannabidiol did not affect food intake nor activity. 5 These results suggest that SR141716A may affect the actions of endogenous cannabinoids in regulating appetite or that it may have effects of its own aside from antagonism of cannabinoid effects (e.g., decreased feeding behavior and locomotor stimulation). In either case, these results strongly suggest that CB1 receptors may play a role in regulation of feeding behavior