Research of the structure of gallstones by IR-spectroscopy method

The composition of gallstones was studied by IR spectroscopy. It is shown that it is possible to establish the presence in the gallstones of such compounds as bilirubin and its salts, calcium phosphates, calcium carbonate, which are present in them in small amounts and difficult to determine

The role of HR - Manager in the effective management of human resources

The article describes the duties and responsibilities of a competent HR- manager. It stresses that a good HR-manager must possess a certain set of professional knowledge: the knowledge of the economy and the market system, understanding of entrepreneurship and business principles. This specialist should fulfil certain professional duties - to manage the personnel - it means being a psychologist to understand any person, to combine available human resources in order to fulfil the potential of the company. According to official statistics, in companies where a personnel manager works, employees’ productivity increases by an average of 20%. In conclusion, it is proved that the position of a personnel manager of the company is necessary for the successful operation of the company, and for the positive positioning of the company in the market.В статье рассматриваются обязанности компетентного менеджера по персоналу. Указывается то, что хороший менеджер по кадрам должен обладать определённым набором профессиональных знаний: знаниями экономики и рыночной системы, пониманием функционирования частного предпринимательства и деловых принципов. Этот специалист должен выполнять определённые профессиональные обязанности - управлять персоналом, что подразумевает умение быть хорошим психологом и разбираться в людях с первого взгляда, совмещать доступные человеческие ресурсы для успешной реализации потенциала компании. В соответствии с официальной статистикой, в компаниях, имеющих должность менеджера по персоналу, производительность работников возрастает в среднем на 20%. В заключении доказывается, что должность менеджера по персоналу необходима для успешной деятельности компании и позиционирования компании на рынке

Response of Respiratory Flour Allergics in an Ingested Flour Challenge May Involve Plasmacytoid Dendritic Cells, CD25+ and CD152+ T Cells

Background: A number of occupational respiratory allergens are food related, and little is known about the responses these allergens elicit in sensitized persons that ingest them. Methods: Nine respiratory fl our-allergic volunteers were exposed in a double-blind placebocontrolled food challenge with fl our. Responses were monitored by spirometry, acoustic rhinometry, determination of urinary methyl histamine and tryptase and fl ow cytometric evaluation of basophil, dendritic and T cell numbers and markers. Results: Signifi cant increases in serum tryptase (compared with placebo post-exposure levels) and methyl histamine and a coordinated decrease in blood basophils and nasal volume after ingestion of allergen compared with placebo suggest an allergic response to ingested allergen. There was no change in forced expiratory volume in 1 s. The number of blood plasmacytoid dendritic cells (DC), but not of myeloid DC, decreased after exposure (p = 0.001). DC HLA DR was reduced after both exposures (p ! 0.001). Expression of CXCR4 on DC was reduced after allergen (p = 0.033) but not after placebo exposure. CD4+ T cell expression of CD25 was elevated after placebo (p = 0.021) but reduced after allergen provocation. The reduction in CD25 expression after allergen compared with placebo was signifi cant (p = 0.024). CD152 was downregulated on these cells after allergen (p = 0.039) but less so after placebo exposure. Conclusion: Persons with respiratory allergy respond after ingestion of the relevant allergen. Response to this allergen challenge may selectively recruit plasmacytoid DC through CXCR4 and T cells expressing CD25 and CD152, which may be a regulatory phenotype

Plasma concentrations of ascorbic acid in a cross section of the German population

Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population. Methods As part of a consultant–patient seminar on nutrition and food intolerances, patients were asked to participate in this study on a voluntary basis. Blood samples were taken for analysis of serum vitamin C concentrations, and all patients were asked to complete a questionnaire. The vitamin C concentration was determined by high-performance liquid chromatography. Results Of approximately 300 patients attending the seminar, 188 (62.6%) consented to vitamin C blood sample analysis and 178 (59.3%) answered the questionnaire. The mean vitamin C concentration was 7.98 mg/L (range, 0.50–17.40; reference range, 5–15 mg/L). A low plasma level with vitamin C insufficiency (<5 mg/L) was found in 31 patients (17.4%), and a potential scorbutogenic deficiency (<1.5 mg/L) was found in 6 (3.3%). Conclusions Potential vitamin C insufficiency and deficiency is common. It is therefore possible, even in modern developed populations, that certain individuals may require a higher intake of vitamin C