Media 1: Subaperture correlation based digital adaptive optics for full field optical coherence tomography

Originally published in Optics Express on 06 May 2013 (oe-21-9-10850

Sample phase extraction of a baseline measurement.

<p>Over the measurement period of 12 s several small eye movements can be seen resulting in pronounced changes in Ф₁ and Ф₂, but almost unchanged ΔФ. In addition, the eye also shows a slight overall movement resulting in shifts of Ф₁ and Ф₂ over time.</p

Calculation of angle .

<p>Angle as calculated from measurements using OCT (red) and LDV (blue) from the two channels. Calculations were done at baseline conditions as well as during hyperoxia.</p

Geometrical situation at the posterior pole of the eye.

<p> and , probe beam wave vectors; , velocity vector; and , Doppler angles; , separation angle between probe beams; , angle between and the plane perpendicular to the detection plane; , change in illumination angle due to eye movement.</p

SLO fundus image of a venous junction.

<p>Angle is determined from the slope of the tangent to the vessel at the measured location. w_sl,x, w_sl,y; image width in x- and y-direction. DP; detection plane.</p

Bland-Altman of velocity measurements.

<p>Bland-Altman plot comparing velocity data as obtained with laser Doppler velocimetry and with bidirectional Doppler FD-OCT. Data are presented for baseline conditions as well as for conditions during systemic hyperoxia.</p

Sample phase extraction of a baseline measurement.

<p>Over the measurement period of 12 s the eye moved relative to the incoming laser beams resulting in pronounced changes in Ф₁ and Ф₂, but almost unchanged ΔФ.</p

Bland-Altman plot of blood flow calculation.

<p>Bland-Altman plot comparing retinal blood flow data as calculated from measurements of blood flow velocity obtained either with laser Doppler velocimetry or with bidirectional Doppler FD-OCT combined with diameter measurements with the Dynamic Vessel Analyzer. Data are presented for baseline conditions as well as for conditions during systemic hyperoxia.</p

Velocity, diameter and blood flow data under baseline conditions and during 100% oxygen breathing measured on Doppler OCT or Laser Doppler Velocimetry study day.

<p>Velocity, diameter and blood flow data under baseline conditions and during 100% oxygen breathing measured on Doppler OCT or Laser Doppler Velocimetry study day.</p

Correlation analysis for velocity measurements.

<p>Correlation between velocity and blood flow as assessed with LDV and OCT, respectively, during baseline conditions and during hyperoxia.</p