Maternal fluoxetine exposure alters cortical hemodynamic and calcium response of offspring to somatosensory stimuli

Epidemiological studies have found an increased incidence of neurodevelopmental disorders in populations prenatally exposed to selective serotonin reuptake inhibitors (SSRIs). Optical imaging provides a minimally invasive way to determine if perinatal SSRI exposure has long-term effects on cortical function. Herein we probed the functional neuroimaging effects of perinatal SSRI exposure in a fluoxetine (FLX)-exposed mouse model. While resting-state homotopic contralateral functional connectivity was unperturbed, the evoked cortical response to forepaw stimulation was altered in FLX mice. The stimulated cortex showed decreased activity for FLX versus controls, by both hemodynamic responses [oxyhemoglobin (Hb

Analysis of the Fabrication Conditions in Organic Field-Effect Transistors

Polymer-based organic field-effect transistors have raised substantial awareness because they enable low-cost, solution processing techniques, and have the potential to be implemented in flexible, disposable organic electronic devices. The performance of these devices is highly dependent on the processing conditions, as well as the intrinsic properties of the polymer. Processing conditions play an important role in semiconductor film formation and device performance. These factors may provide an important link between structure and performance. In this study, an empirical analysis tool, Process Scout, was applied to assess processing factors such as polymer concentration and silicon modification. This sanctioned the creation of a realistic optimization model because common variance was not assumed and the mobility was capably analyzed in the real space. After the analysis of the processing conditions, it was evident that further study on the effect of humidity on performance must be conducted to account for the variance between similarly fabricated devices. The developed process may be applied to expand the study of other organic semiconductors. This process is the first step in creating a standard fabrication protocol, allowing organic field-effect transistors to prosper

Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders

BACKGROUND: Motor deficits such as abnormal gait are an underappreciated yet characteristic phenotype of many neurodevelopmental disorders (NDDs), including Williams Syndrome (WS) and Neurofibromatosis Type 1 (NF1). Compared to cognitive phenotypes, gait phenotypes are readily and comparably assessed in both humans and model organisms and are controlled by well-defined CNS circuits. Discovery of a common gait phenotype between NDDs might suggest shared cellular and molecular deficits and highlight simple outcome variables to potentially quantify longitudinal treatment efficacy in NDDs. METHODS: We characterized gait using the DigiGait assay in two different murine NDD models: the complete deletion (CD) mouse, which models hemizygous loss of the complete WS locus, and the Nf1 RESULTS: Compared to wildtype littermate controls, both models displayed markedly similar spatial, temporal, and postural gait abnormalities during development. Developing CD mice also displayed significant decreases in variability metrics. Multiple gait abnormalities observed across development in the Nf1 CONCLUSIONS: These findings suggest that the subcomponents of gait affected in NDDs show overlap between disorders as well as some disorder-specific features, which may change over the course of development. Our incorporation of spatial, temporal, and postural gait measures also provides a template for gait characterization in other NDD models and a platform to examining circuits or longitudinal therapeutics

’Let’s Call Ourselves the Super Elite’: Using the Collective Behavior Tradition to Analyze Trump’s America

The mid‐twentieth century “collective behavior” school asserted that (1) collective behavior—the actions of crowds, movements, and other gatherings—had distinct dynamics; (2) such action was often “nonrational,” or not governed by cost‐benefit calculation; and (3) collective behavior could pose a threat to liberal democracy because of these features. While this tradition fell out of scholarly favor, the 2016 election has given us empirical reasons to revisit some elements of collective behavior approaches. We argue for three key orienting concerns, drawn from this tradition, to understand the current political era. First is a focus on authoritarianism and populism, particularly among those who feel disaffected and isolated from political institutions, pared of psychologistic determinism and geared more sensitively to their manifestations as a political style. Second is a focus on racialized resentment, strain, and perceptions of status decline, especially in how such feelings are activated when people are confronted with disruptions to their lives. Third is an analysis of “emergent norms” and the extent to which political actors produce normative understandings of contextually appropriate action that are distinct from traditional political behavior. We elaborate on these themes, apply them to examples from current politics, and suggest ways to incorporate them into contemporary sociological research