Islet slow oscillator recruitment by sinusoidal glucose signals with 10 min period.

<p>Imposed glucose oscillations with a period as slow as 10 min can activate the slow islet oscillator. (A) Slow Ca²⁺ oscillations were entrained by a sinusoidal glucose signal with 10 min period. (B) Slow Ca²⁺ oscillations were triggered with a period approximately half that of the imposed glucose signal in another islet.</p

Model glycolytic oscillator recruitment.

<p>A sinusoidal external glucose signal with baseline <i>G</i>_<i>e</i> = 15 mM, greater than the Hopf bifurcation at <i>G</i>_mid ≈ 14.5 mM, must have sufficiently large amplitude and period to activate the DOM glycolytic oscillator. (A) External glucose oscillations started with 0.5 mM amplitude and 5 min period (<i>t</i> < 60 min) trigger large-amplitude FBP oscillations only after the amplitude of glucose oscillations is increased to cross below <i>G</i>_mid ≈ 14.5 mM (<i>t</i> > 60 min). (B) Although glucose oscillations started with 1 mM amplitude and 1 min period (<i>t</i> < 60 min) cross below <i>G</i>_mid, they trigger large-amplitude FBP oscillations only after the period of glucose oscillations is increased to 5 min (<i>t</i> > 60 min).</p