6 research outputs found
Renal histopathology.
<p>Glomerular retraction and sclerosis (Glomerular lesions); tubular atrophy, hyperplasia and thickening of basement membrane (Tubular lesions); and interstitial edema and infiltrate (Interstitial lesions) in rats fed diets with normal fat and normal phosphorus (NF-NP), high fat and normal phosphorus (HF-NP) and high fat and low phosphorus (HF-LP).</p
Diet vs urine & plasma P and FGF23.
<p>Correlation between P ingested and (A) P urine (r<sup>2</sup> = 0.663, p<0.001), (B) P plasma (r<sup>2</sup> = 0.004, p = 0.806), and (C) FGF23 plasma (r<sup>2</sup> = 0.130, p = 0.187) in rats fed high fat diets with normal and low phosphorus content.</p
Plasma FGF23, urinary excretion of P and renal NaPiIIa.
<p><b>(A)</b> Circulating concentrations of FGF23 in rats (n = 8 per group) fed diets with normal fat and normal phosphorus (NF-NP), high fat and normal phosphorus (HF-NP) and high fat and low phosphorus (HF-LP). (B) Urinary excretion of P (mg/day) in rats (n = 8 per group) fed diets with normal fat and normal phosphorus (NF-NP), high fat and normal phosphorus (HF-NP) and high fat and low phosphorus (HF-LP). (C) Expression of NaPiIIa in the kidneys of rats (n = 8 per group) fed diets with normal fat and normal phosphorus (NF-NP), high fat and normal phosphorus (HF-NP) and high fat and low phosphorus (HF-LP). The original gel from which blots have been extracted is shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0198481#pone.0198481.s001" target="_blank">S1 Fig</a>. <sup>a</sup>p<0.05 vs NF-NP, <sup>b</sup>p<0.05 vs HF-NP.</p
Renal klotho.
<p>Klotho mRNA (A) and protein (B) in the kidneys of rats (n = 8 per group) fed diets with normal fat and normal phosphorus (NF-NP), high fat and normal phosphorus (HF-NP) and high fat and low phosphorus (HF-LP). The original gel from which blots have been extracted is shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0198481#pone.0198481.s002" target="_blank">S2 Fig</a>. <sup>a</sup>p<0.05 vs NF-NP.</p
Blood biochemistry.
<p>Plasma concentrations of parameters related to energy metabolism, mineral metabolism, renal function, and inflammation in rats fed diets with normal fat and normal phosphorus (NF-NP), high fat and normal phosphorus (HF-NP) and high fat and low phosphorus (HF-LP).</p
Body weight.
<p>Increase in body weight after the 7 months that lasted the experiments in rats (n = 8 per group) fed diets with normal fat and normal phosphorus (NF-NP), high fat and normal phosphorus (HF-NP) and high fat and low phosphorus (HF-LP). <sup>a</sup>p<0.05 vs NF-NP.</p