7 research outputs found
La ciclooxigenasa-2 como factor patogénico en el cáncer colorrectal. Implicaciones terapeúticas
Tumores del estroma gastrointestinal de localización rectal
Los tumores del estroma gastrointestinal
(GIST) son neoplasias de origen
mesenquimal que se localizan en el tracto
gastrointestinal y representan el 2o/o
de todos los tumores de esta localización.
Los GIST de localización rectal son muy
poco frecuentes y la experiencia de la
mayor parte de los hospitales es muy limitada.
Los tumores < 5 cm, a menudo,
son silentes y se descubren de forma incidental.
La expresión de CD-11 7 es el
marcador diagnóstico más específico de
los GIST y permite el diagnóstico diferencial
con otras neoplasias mesenquimales
del tracto gastrointestinal de origen
neural o muscular. Presentamos dos casos
de tumor estroma! de localización rectal
tratados en el Servicio de Cirugía General
del Hospital Médico-Qufrúrgico de
Jaén. El diagnóstico fue establecido en
hase a la positividad de la expresión de
CD-11 7. En uno de ellos se realizó neoadyuvancia
con mesilato de imatinib. En
ambos casos se práctico exéresis del
tumor por vía endoanal
Fracaso renal agudo secundario a nefritis intersticial granulomatosa asociada al tratamiento con tramadol
Acute kidney injury due to granulomatous interstitial nephritis induced by tramadol administration
TFG-β Nuclear Staining as a Potential Relapse Risk Factor in Early-Stage Non-Small-Cell Lung Cancer.
Nowadays, the impact of the tumor-immune microenvironment (TME) in non-small-cell lung cancer (NSCLC) prognosis and treatment response remains unclear. Thus, we evaluated the expression of PD-L1, tumor-infiltrating lymphocytes (TILs), and transforming growth factor beta (TGF-β) in NSCLC to identify differences in TME, detect possible new prognostic factors, and assess their relationship. We retrospectively analyzed 55 samples from patients who underwent NSCLC surgery and had over a 5-year follow-up. PD-L1 expression was determined by immunohistochemistry following standard techniques. The presence of TILs was evaluated at low magnification and classified into two categories, “intense” and “non-intense”. Cytoplasmic TGF-β staining visualization was divided into four categories, and unequivocal nuclear staining in >1% of viable tumor cells was defined as “present” or “absent”. Our aim was to identify differences in disease-free survival (DFS) and overall survival (OS). Tumor stage was the only objective prognostic factor for OS. PD-L1 expression and the presence of TILs had no prognostic impact, neither their combination. There seems to be a lower expression of PD-L1 and a higher expression of TILs in early stages of the disease. Our TGF-β nuclear staining analysis was promising, since it was associated with worse DFS, revealing this protein as a possible prognostic biomarker of recurrence for resectable NSCLC