Dectin-2, DC-SIGN and MCP-1 polymorphisms associated with rheumatoid arthritis.

1<p>Models adjusted for age and gender.</p>2<p>Models adjusted for age.</p>3<p><i>p</i> value for testing of effect modification by gender was calculated utilizing an interaction term of gender and genetic polymorphism assuming a co-dominant model of inheritance. <i>P</i><0.05 in bold. Abbreviations: OR, odds ratio; CI, confidence interval.</p

MDR analysis to detect two-locus disease models.

<p>TA, Testing accuracy; CVC, Cross-validation consistency. P<0.05 was considered significant. NS, not significant.</p>*<p>P-value for testing balanced accuracy using 1.000-fold permutation test (MDR permutation testing module vs.0.4.9 alpha).</p

Demographic and clinical characteristics of RA patients.

<p>Data are means ± standard deviation. Abbreviations: RF, rheumatoid factor; Anti-CCP: anti-cyclic citrullinated peptide antibodies; DAS28, disease activity score; DMARDs, disease-modifying antirheumatic drugs.</p>*<p>Anti-CCP value was available only in 314 patients (254 women and 60 men).</p

Selected SNPs within DC-SIGN, Dectin-1, Dectin-2, MCP-1 and CCR2 genes.

<p>Abbreviations: UTR, untranslated region; IPA, Invasive Pulmonary Aspergillosis; TB, Tuberculosis; COPD, Chronic obstructive pulmonary disease; HCV, Hepatitis C virus; HBV, Hepatitis B virus; HIV-1, Human immunodeficiency virus-1; SARS, acute severe respiratory syndrome.</p>‡<p>Minor allele frequency found in our population (458 RA patients and 512 controls).</p>*<p>Tagging details and references are included as Supplementary material.</p

Overall analysis of Dectin-2, DC-SIGN and MCP-1 polymorphisms with rheumatoid arthritis.

1<p>Models adjusted for age, gender and center.</p>2<p>Models adjusted for age and center.</p>3<p><i>p</i> value for testing of effect modification by gender was calculated utilizing an interaction term of gender and genetic polymorphism assuming a co-dominant model of inheritance. <i>P</i><0.05 in bold. Abbreviations: OR, odds ratio; CI, confidence interval.</p