Ethyl 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

In the title compound, C15H12ClFN2O5, molecules are packed in the crystal lattice in a parallel fashion sustained by various C—H...O [C...O = 3.065 (5)–3.537 (5) Å] and C—H...Cl [3.431 (5)–3.735 (4) Å] interactions

Synthesis, Characterization, Crystal Structure, and DFT Study of a New Square Planar Cu(II) Complex Containing Bulky Adamantane Ligand

A copper complex with square planar geometry, [(L)CuBr2] (1), (L = N′-(furan-2-ylmethylene)adamantne-1-carbohydrazide) has been synthesized and characterized by Fourier transfer infrared (FTIR) spectroscopy, elemental analysis, mass spectrometry, and single crystal X-ray diffraction. The crystal of 1 is solved as monoclinic, space group P21/m with unit cell parameters: a = 10.8030(8), b = 6.6115(8), c = 12.1264(12) Å, β = 101.124(8)°, V = 849.84(15) Å3, Z = 2, and R1 = 0.0751 with wR2 = 0.1581 (I > 2 σ). The structure of 1 shows intramolecular hydrogen bonding between the N–H and the furan oxygen which stabilizes the configuration of the complex. Furthermore, inside the lattice there are other weak interactions between bromo ligands and the ligand L. DFT calculations where performed to study the stability of this geometry

Development of magnetic Fe3O4-chitosan immobilized Cu(II) Schiff base catalyst: An efficient and reusable catalyst for microwave assisted one-pot synthesis of propargylamines via A3 coupling

A novel heterogeneous catalyst (Fe3O4@CS@Schiffbase@Cu) is developed by generating the Cu(II) Schiff base complex on the Fe3O4-chitosan surface. The structural and morphological characteristics of the catalyst is confirmed by all physicochemical techniques. A low catalyst loading (1.1 mol% Cu) of the immobilized Cu(II) Schiff base complex shows its catalytic activity for A3 coupling reaction of Aldehyde, Alkyne, and Amines under microwave irradiation. The catalyst was proven very active for a wide variety of propargylamines syntheses using different substituted aromatic aldehydes, secondary amines, and phenylacetylene under optimized conditions. The recyclability of the catalyst was efficient even after six cycles with a 95% efficiency

2-(4-Methylphenyl)quinoline-4-carboxylic acid

In the title compound, C17H13NO2, the dihedral angle between the plane of the carboxy group and the quinoline mean plane is 45.05 (13)°, and that between the toluene ring mean plane and the quinoline mean plane is 25.29 (7)°. In the crystal, molecules are linked via O—H....N hydrogen bonds, forming chains propagating along the b-axis direction. These chain are linked via C—H...O interactions, forming two-dimensional networks lying parallel to the ab plane

Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes

Four new complexes derived from adamantly containing hydrazone (APH) ligand with Cu(II) (1), Co(II) (2), Ni(II) (3) and Zn(II) (4), have been synthesized and characterized using different physicochemical methods. The structure of the ligand APH and its copper complex 1 have been established by single-crystal X-ray diffraction direct methods, which reveal that complex 1 has distorted square-pyramidal geometry. Complexes 1–4 are screened against seven human cancer cell lines namely, breast cancer cell lines (MCF7, T47D, MDA-MB-231), prostate cancer cell lines (PC3, DU145) and the colorectal cancer cell line Coco-2, for their antiproliferative activities. Complex 1 has shown a promising anticancer activity compared to the other ones. The structural and spectroscopic analysis of APH and its complexes are confirmed by DFT calculations

Heterocycles [h]-fused to 4-oxoquinoline-3-carboxylic acid. Part XI: Synthesis and antibacterial activity of 4-fluoro-6-oxoimidazo[4,5-h]quinoline-7-carboxylic acids

A series of 2-hetaryl-4-fluoro-9-cyclopropyl- 6-oxo-1H-imidazo[4,5-h]quinoline-7-carboxylic esters ( 3a–f) and their corresponding acids 4a–f have been prepared via microwave-assisted cyclocondensation reaction with some hetarene carboxaldehydes. The structures for these new esters and acids are based on spectral (IR, MS, and NMR) data. The in vitro antimicrobial assay of 4a–f hetaryl derivatives, their aryl analogues 1d–g, and the imidazo-unsubstituted acid 1a showed that all of these tricyclic heterocycles possess a good level of antibacterial activity. Among them, compound 1a exhibited the highest effect against both, Gram-positive (minimum inhibitory concentrations [MICs] 0.15–3.0 μg mL-1) and Gram-negative bacteria (MICs 0.7–3.0 μg mL-1). An excellent activity was recorded also for the halo-phenyl derivatives 1f,g and for the furan derivatives 4e,f, especially toward Gram-positive strains and Bacillus subtilis and Haemophilus influenzae, respectively

“JPET #59618” NC381, A NOVEL ANTICANCER AGENT, ARRESTS THE CELL CYCLE IN G0-G1 AND INHIBITS LUNG TUMOR CELL GROWTH IN VITRO AND IN VIVO

Number of text pages: 33 Number of tables: 0 Number of figures: 8 Number of references: 40 Number of words in the Abstract: 250 Number of words in the Introduction: 727 Number of words in the Discussion: 1441 Abbreviations: CDK, cyclin dependent kinase; pRb, product of the retinoblastoma susceptibility gene; Ink4, inhibitor of CDK4; Kip1, kinase inhibitory protein 1; Cip, CD