Everett and the Born Rule

During the last ten years or so, derivations of the Born rule based on decision theory have been proposed and developed, and it is claimed that these are valid in the context of the Everett interpretation. This claim is critically assessed and it is shown that one of its key assumptions, although natural in the context of the Copenhagen interpretation, is not consistent with that of Everett. It is further argued that any interpretation that relates outcome likelihood to the expansion coefficients connecting the wavefunction with the eigenfunctions of the measurement operator must be inconsistent with the Everett interpretation.Comment: 22 pages 1 figur

The construction of self-dual normal polynomials over GF(2) and their applications to the Massey-Omura algorithm

Gaussian periods are used to locate a normal element of the finite field GF(2e) of odd degree e and an algorithm is presented for the construction of self-dual normal polynomials over GF(2) for any odd degree. This gives a new constructive proof of the existence of a self-dual basis for odd degree. The use of such polynomials in the Massey-Omura multiplier improves the efficiency and decreases the complexity of the multiplie

Radiosensitization of noradrenaline transporter-expressing tumour cells by proteasome inhibitors and the role of reactive oxygen species

Background The radiopharmaceutical 131I-metaiodobenzylguanidine (131I-MIBG) is used for the targeted radiotherapy of noradrenaline transporter (NAT)-expressing neuroblastoma. Enhancement of 131I-MIBG's efficacy is achieved by combination with the topoisomerase I inhibitor topotecan - currently being evaluated clinically. Proteasome activity affords resistance of tumour cells to radiation and topoisomerase inhibitors. Therefore, the proteasome inhibitor bortezomib was evaluated with respect to its cytotoxic potency as a single agent and in combination with 131I-MIBG and topotecan. Since elevated levels of reactive oxygen species (ROS) are induced by bortezomib, the role of ROS in tumour cell kill was determined following treatment with bortezomib or the alternative proteasome inhibitor, MG132.<p></p> Methods Clonogenic assay and growth of tumour xenografts were used to investigate the effects of proteasome inhibitors alone or in combination with radiation treatment. Synergistic interactions in vitro were evaluated by combination index analysis. The dependency of proteasome inhibitor-induced clonogenic kill on ROS generation was assessed using antioxidants.<p></p> Results Bortezomib, in the dose range 1 to 30 nM, decreased clonogenic survival of both SK-N-BE(2c) and UVW/NAT cells, and this was prevented by antioxidants. It also acted as a sensitizer in vitro when administered with X-radiation, with 131I-MIBG, or with 131I-MIBG and topotecan. Moreover, bortezomib enhanced the delay of the growth of human tumour xenografts in athymic mice when administered in combination with 131I-MIBG and topotecan. MG132 and bortezomib had similar radiosensitizing potency, but only bortezomib-induced cytotoxicity was ROS-dependent.<p></p> Conclusions Proteasome inhibition shows promise for the treatment of neuroblastoma in combination with 131I-MIBG and topotecan. Since the cytotoxicity of MG132, unlike that of bortezomib, was not ROS-dependent, the latter proteasome inhibitor may have a favourable toxicity profile in normal tissues.<p></p&gt

Countering the Norm, (Re)authoring Our Lives: The Promise Counterstorytelling Holds as a Research Methodology With LGBTQ Youth and Beyond

Counterstorytelling, a methodology that is rooted in critical race theory, is undergirded by principles that are beneficial to understanding the experiences of lesbian, gay, bisexual, transgender, and queer-identified (LGBTQ) young people from an intersectional perspective. Counterstorytelling holds promise as a method that creates opportunities for individual transformation and resistance to dominant narratives among young people facing systemic oppression. This article outlines the design and implementation of a counterstorytelling study with LGBTQ youth and reflects on the value and associated challenges of counterstorytelling as a participatory research method

Organic slug control using Phasmarhabditis hermaphrodita

Phasmarhabditis hermaphrodita is a lethal slug parasitic nematode that has been formulated into an effective biological control agent called Nemaslug®. We investigated the possibility of using different application methods of P. hermaphrodita to reduce cost and the number of nematodes applied. We also compared P. hermaphrodita with a new slug pellet called Ferramol®, which is available for use on organic farms

NEW ZEALAND'S STATUTORY MARKETING BOARDS: THEIR HISTORY AND SOME RECENT DEVELOPMENTS

Marketing,