Investigating the attitude of medical students to the effect of applying correct skills of teacher-student communication on learning physiology

Background: Physiology is one of the most basic lessons among medical education courses. The teacher can facilitate the teaching process for compensating deficiencies in textbooks.Method: This study was a descriptive cross-sectional study and the available sampling method was used. The study population in this study was students of Abadan University of Medical Sciences who had physiology lessons in their curriculum in the first semester of the 2019-2020 academic years.Results: The results showed that respect for the student's personality, teacher's scientific mastery of the subject of teaching and a few minutes break between teaching with %95.7, the flexibility of the teacher and the interest in teaching with 92.7%, the up-to-datedness of the teacher with 92.7%, and the way of speaking and pleasantness of the teacher with 91.3% have the greatest impact on increasing learning of students. On the other hand, teacher's strictness with %46.5 and teacher's stubbornness with %8.7 had the least effect on increasing student's learningConclusions: The results obtained regarding the correct communication skills between teacher and students as the most effective in better learning physiology lessons and the highest scores, respectively, were:: teacher's scientific mastery, teacher's expression, respect for the student's personality by the teacher, teacher's up to dateness, teacher's flexibility, teacher's sobriety, teacher's appropriate class management, teacher's high self-confidence, teacher's patience, teacher's kindness, and teacher's interest in teaching

The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer

To assess the prognostic value of “liquid biopsies” for the benefit of salvage RT in oligometastatic prostate cancer relapse, we enrolled 44 patients in the study between the years 2016 and 2020. All the patients were diagnosed as having an oligometastatic prostate cancer relapse on prostate-specific membrane antigen (PSMA)-targeted PET-CT and underwent irradiation at the Department of Radiotherapy at the Hannover Medical School. Tumor cells and total RNA, enriched from the liquid biopsies of patients, were processed for the subsequent quantification analysis of relative transcript levels in real-time PCR. In total, 54 gene transcripts known or suggested to be associated with prostate cancer or treatment outcome were prioritized for analysis. We found significant correlations between the relative transcript levels of several investigated genes and the Gleason score, PSA (prostate-specific antigen) value, or UICC stage (tumor node metastasis -TNM classification of malignant tumors from Union for International Cancer Control). Furthermore, a significant association of MTCO2, FOXM1, SREBF1, HOXB7, FDXR, and MTRNR transcript profiles was found with a temporary and/or long-term benefit from RT. Further studies on larger patients cohorts are necessary to prove our preliminary findings for establishing liquid biopsy tests as a predictive examination method prior to salvage RT

Assessment of an APOBEC3B truncating mutation, c.783delG, in patients with breast cancer.

APOBEC3B belongs to the family of DNA-editing enzymes. A copy number variant targeting the genomic APOBEC3A-APOBEC3B locus has a significant impact on breast cancer risk, but the relative contribution of APOBEC3B is uncertain. In this study, we investigate a loss-of-function mutation that selectively targets APOBEC3B, for its association with breast cancer risk