The Virulence in the Guinea-pig of Tubercle Bacilli Isolated before Treatment from South Indian Patients with Pulmonary Tuberculosis: 1. Homogeneity of the Investigation and a Critique of the Virulence Test

A series of studies on the virulence in the guinea-pig of tubercle bacilli isolated before treatment from Indian tuberculous patients admitted to a controlled comparison of different regimens of domiciliary chemotherapy has recently been undertaken by the Tuberculosis Chemotherapy Centre, Madras. The main object of these studies was to determine whether the differences in virulence of the tubercle bacilli obtained from Indian patients before the start of chemotherapy were related to the severtiy or type of the patients’ disease at that time and to the subsequent response to treatment. Before these relationships could be‘ investigated, however, it was necessary to find out whether the results of the virulence tests, which were carried out over a period of two-and-a-half years at the Centre and at the Microbiological Research Establishment, Porton, England, could be considered as a unified whole-that, is, as if they had all been done on the same day in the same laboratory. A proportion of the cultures was stored at – 20°C for 44-78 weeks, but this did not affect their virulence. Inter-experimental variation was found to be small in the Porton series of tests and undetectable in the Madras series, and the results in the latter series could be successfully adjusted to those in the former by allowing for differences in the means and standard deviations of the distributions for the two series. The measure of virulence used was found to be reasonably acceptable for the analysis of variance technique. Suggestions are made as to ways of improving the efficiency of the experimental design in future studies

The Chandrayaan-2 Large Area Soft X-ray Spectrometer (CLASS)

The CLASS experiment on Chandrayaan-2, the second Indian lunar mission, aims tomap the abundance of the major rock forming elements on the lunar surface using the technique of X-ray fluorescence during solar flare events. CLASS is a continuation of the successful C1XS [1] XRF experiment on Chandrayaan-1. CLASS is designed to provide lunar mapping of elemental abundances with a nominal spatial resolution of 25 km (FWHM) from a 200 km polar, circular orbit of Chandrayaan-2

The Virulence in the Guinea-pig of Tubercle Bacilli Isolated before Treatment from South Indian Patients with Pulmonary Tuberculosis 3. Virulence related to Pretreatment Status of Disease and to Response to Chemotherapy

This is the last of a series of three reports from the Tuberculosis Chemotherapy Centre Madras, on a study undertaken with the object of finding out whether differences in the virulence in the guinea-pig of tubercle bacilli isolated from South Indian tuberculous patients before the start of chemotherapy are related to the severity of the patients’ disease on admission to treatment and to the subsequent response to chemotherapy. The 281 patients in this study were drawn from the patients admitted to a l-year comparison of four domiciliary chemotherapeutic regimens : (a) 3.9-5.5 mg/kg isoniazid plus 0.2-0.3 g/kg sodium PAS daily, divided into two doses (PH series) ; (b) 7.8-9.6 mg/kg isoniazid alone daily in one dose (HI-I series) ; (c) 7.8-9.6 mg/kg isoniazid alone daily, divided into two doses (HI-2 series) ; (d) 3.9-5.5 mg/kg isoniazid alone daily, divided into two doses (H series). No evidence was found of an association between the virulence of the organisms and any pretreatment condition of known prognostic importance. There was no association between pretreatment virulence and progress during treatment in the PH series (the most effective regimen). In the other series, however, the progress was more satisfactory in patients infected with organisms of low virulence than in those infected with organisms of high virulence, the association between virulence and progress attaining statistical significance in the combined HI-2 and H series (the least effective regimens) and only just failing to do so in the smaller HI-1 series. Possible explanations are put forward both for the absence of an association between virulence and severity of disease on admission and for the presence of an association between virulence and response in the patients treated with isoniazid alone

Magnetic anomalies of offshore Krishna-Godavari basin, eastern continental margin of India

The marine magnetic data acquired from offshore Krishna-Godavari (K-G) basin, eastern continental margin of India (ECMI), brought out a prominent NE-SW trending feature, which could be explained by a buried structural high formed by volcanic activity. The magnetic anomaly feature is also associated with a distinct negative gravity anomaly similar to the one associated with 85°E Ridge. The gravity low could be attributed to a flexure at the Moho boundary, which could in turn be filled with the volcanic material. Inversion of the magnetic and gravity anomalies was also carried out to establish the similarity of anomalies of the two geological features (structural high on the margin and the 85°E Ridge) and their interpretations. In both cases, the magnetic anomalies were caused dominantly by the magnetization contrast between the volcanic material and the surrounding oceanic crust, whereas the low gravity anomalies are by the flexures of the order of 3-4 km at Moho boundary beneath them. The analysis suggests that both structural high present in offshore Krishna-Godavari basin and the 85°E Ridge have been emplaced on relatively older oceanic crust by a common volcanic process, but at discrete times, and that several of the gravity lows in the Bay of Bengal can be attributed to flexures on the Moho, each created due to the load of volcanic material

Self-similar shear-thickening behavior in CTAB/NaSal surfactant solutions

The effect of salt concentration Cs on the critical shear rate required for the onset of shear thickening and apparent relaxation time of the shear-thickened phase, has been investigated systematically for dilute CTAB/NaSal solutions. Experimental data suggest a self-similar behavior of the critical shear rate and relaxation time as functions of Cs. Specifically, the former ~ Cs^(-6) whereas the latter ~ Cs^(6) such that an effective Weissenberg number for the onset of the shear thickened phase is only weakly dependent on Cs. A procedure has been developed to collapse the apparent shear viscosity versus shear rate data obtained for various values of Cs into a single master curve. The effect of Cs on the elastic modulus and mesh size of the shear-induced gel phase for different surfactant concentrations is discussed. Experiments performed using different flow cells (Couette and cone-and-plate) show that the critical shear rate, relaxation time and the maximum viscosity attained are geometry-independent. The elastic modulus of the gel phase inferred indirectly by employing simplified hydrodynamic instability analysis of a sheared gel-fluid interface is in qualitative agreement with that predicted for an entangled phase of living polymers. A qualitative mechanism that combines the effect of Cs on average micelle length and Debye parameter with shear-induced configurational changes of rod-like micelles is proposed to rationalize the self-similarity of SIS formation.Comment: 27 pages, 17 figure

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ACETYLSALICYLIC ACID VIA CO-CRYSTALLIZATION TECHNIQUE: A NOVEL ASA-VALINE COCRYSTAL

Objective: This study aims to synthesize acetylsalicylic acid (ASA) cocrystals using valine as a coformer via a co-crystallization technique to increase the solubility and dissolution rate of ASA. Methods: The ASA-valine cocrystal (1:1 molar ratio) was prepared using the solvent evaporation technique with ethanol: water (50:50). The cocrystal was characterized using Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC), Powder X-ray diffraction (PXRD), Scanning electron microscopy (SEM), melting point to confirm the formation of cocrystal. The evaluation of cocrystal was done by drug content determination, solubility and dissolution studies. Results: The prepared cocrystal was successfully confirmed for the formation of a hydrogen bond. The melting point of prepared cocrystal was decreased compared to pure ASA and valine, which indicated the formation of a new crystalline form. The FT-IR studies showed the formation of a new hydrogen bond by shifting the-O-H,-C=O and-N-H functional groups. SEM studies ensured that the prepared cocrystals were in needle-like appearance. Finally, DSC and PXRD studies were also indicated the successful formation of ASA-valine cocrystal. The drug release of cocrystal was found to be 100% at 60th min. Where in the case of pure ASA and marketed product of ASA exhibited the dissolution rate of 59% and 69% at 60th min respectively. Conclusion: The co-crystallization technique can be adopted as the best strategy to increase the solubility and dissolution rate of BCS class 2 drugs. Therefore the prepared ASA-valine cocrystal can be a greater alternative to increase the solubility and dissolution rate compared with pure and marketed ASA

Classical R-Matrices and the Feigin-Odesskii Algebra via Hamiltonian and Poisson Reductions

We present a formula for a classical $r$-matrix of an integrable system obtained by Hamiltonian reduction of some free field theories using pure gauge symmetries. The framework of the reduction is restricted only by the assumption that the respective gauge transformations are Lie group ones. Our formula is in terms of Dirac brackets, and some new observations on these brackets are made. We apply our method to derive a classical $r$-matrix for the elliptic Calogero-Moser system with spin starting from the Higgs bundle over an elliptic curve with marked points. In the paper we also derive a classical Feigin-Odesskii algebra by a Poisson reduction of some modification of the Higgs bundle over an elliptic curve. This allows us to include integrable lattice models in a Hitchin type construction.Comment: 27 pages LaTe

Paleocene on-spreading-axis hotspot volcanism along the Ninetyeast Ridge: an interaction between the Kerguelen hotspot and the Wharton spreading center

Investigations of three plausible tectonic settings of the Kerguelen hotspot relative to the Wharton spreading center evoke the on-spreading-axis hotspot volcanism of Paleocene (60-54 Ma) age along the Ninetyeast Ridge. The hypothesis is consistent with magnetic lineations and abandoned spreading centers of the eastern Indian Ocean and seismic structure and radiometric dates of the Ninetyeast Ridge. Furthermore, it is supported by the occurrence of oceanic andesites at Deep Sea Drilling Project (DSDP) Site 214, isotopically heterogeneous basalts at Ocean Drilling Program (ODP) Site 757 of approximately the same age (59-58 Ma) at both sites. Intermix basalts generated by plume-mid-ocean ridge (MOR) interaction, exist between 11° and 17°S along the Ninetyeast Ridge. A comparison of age profile along the Ninetyeast Ridge between ODP Sites 758 (82 Ma) and 756 (43 Ma) with similarly aged oceanic crust in the Central Indian Basin and Wharton Basin reveals the existence of extra oceanic crust spanning 11° latitude beneath the Ninetyeast Ridge. The extra crust is attributed to the transfer of lithospheric blocks from the Antarctic plate to the Indian plate through a series of southward ridge jumps at about 65, 54 and 42 Ma. Emplacement of volcanic rocks on the extra crust resulted from rapid northward motion (absolute) of the Indian plate. The Ninetyeast Ridge was originated when the spreading centers of the Wharton Ridge were absolutely moving northward with respect to a relatively stationary Kerguelen hotspot with multiple southward ridge jumps. In the process, the spreading center coincided with the Kerguelen hotspot and took place on-spreading-axis volcanism along the Ninetyeast Ridge

Fibre bundle formulation of nonrelativistic quantum mechanics: I. Introduction. The evolution transport

We propose a new systematic fibre bundle formulation of nonrelativistic quantum mechanics. The new form of the theory is equivalent to the usual one but it is in harmony with the modern trends in theoretical physics and potentially admits new generalizations in different directions. In it a pure state of some quantum system is described by a state section (along paths) of a (Hilbert) fibre bundle. Its evolution is determined through the bundle (analogue of the) Schr\"odinger equation. Now the dynamical variables and the density operator are described via bundle morphisms (along paths). The mentioned quantities are connected by a number of relations derived in this work. The present first part of this investigation is devoted to the introduction of basic concepts on which the fibre bundle approach to quantum mechanics rests. We show that the evolution of pure quantum-mechanical states can be described as a suitable linear transport along paths, called evolution transport, of the state sections in the Hilbert fibre bundle of states of a considered quantum system.Comment: 26 standard (11pt, A4) LaTeX 2e pages. The packages AMS-LaTeX and amsfonts are required. Revised: new material, references, and comments are added. Minor style chages. Continuation of quan-ph/9803083. For continuation of the this series see http://www.inrne.bas.bg/mathmod/bozhome

The Voicing Hidden Histories Project: Participatory Video in Development, Soft Power and Film Language

In this article, we wish to reflect upon some of the findings of a recent Arts and Humanities Research Council-funded Global Challenges Research Fund Participatory Video (PV) project ‘Voicing Hidden Histories’. Working in South Africa, India and Brazil, this project has been using PV to support specific marginalised communities in each country to challenge the way their nations present themselves – and in particular their national history – to the world via ‘nation branding’ and other ‘soft power’ initiatives. Specifically, we ask: why use filmmaking as an international development tool? What are the enablers of – and barriers to – successful PV initiatives and what does ‘success’ mean in this context? Moreover, while such projects invariably make claims for PV as a particularly effective method for ‘giving’ communities ‘voice’ – however such potentially patronising terms might be defined – very little space is usually dedicated to the exploration of the films produced in such projects, that is to the specific articulation of this ‘voice’. Thus, we also wish to challenge a trend in the analysis of such projects that focuses entirely on questions of methodology and an understanding of PV as a process, largely ignoring the products made