HST Observations of the Serendipitous X-ray Companion to Mrk 273: Cluster at z=0.46?

We have used HST I-band images to identify Mrk 273X, the very unusual high-redshift X-ray-luminous Seyfert 2 galaxy found by ROSAT in the same field-of-view as Mrk 273. We have measured the photometric properties of Mrk 273X and have also analyzed the luminosity distribution of the faint galaxy population seen in the HST image. The luminosity of the galaxy and the properties of the surrounding environment suggest that Mrk 273X is the brightest galaxy in a relatively poor cluster at a redshift near 0.46. Its off-center location in the cluster and the presence of other galaxy groupings in the HST image may indicate that this is a dynamically young cluster on the verge of merging with its neighboring clusters. We find that Mrk 273X is a bright featureless elliptical galaxy with no evidence for a disk. It follows the de Vaucouleurs (r^{1/4}) surface brightness law very well over a range of 8 magnitudes. Though the surface brightness profile does not appear to be dominated by the AGN, the galaxy has very blue colors that do appear to be produced by the AGN. Mrk 273X is most similar to the IC 5063 class of active galaxies --- a hybrid Sy 2 / powerful radio galaxy.Comment: Accepted for publication in the Astrophysical Journal. 8 pages, including 4 postscript figures. Uses emulateapj.sty and psfig.sty. Higher quality version of Figure 1 is available at http://rings.gsfc.nasa.gov/~borne/fig1-markgals.gi

A Catalog of Candidate Intermediate-luminosity X-ray Objects

ROSAT, and now Chandra, X-ray images allow studies of extranuclear X-ray point sources in galaxies other than our own. X-ray observations of normal galaxies with ROSAT and Chandra have revealed that off-nuclear, compact, Intermediate-luminosity (Lx[2-10 keV] >= 1e39 erg/s) X-ray Objects (IXOs, a.k.a. ULXs [Ultraluminous X-ray sources]) are quite common. Here we present a catalog and finding charts for 87 IXOs in 54 galaxies, derived from all of the ROSAT HRI imaging data for galaxies with cz <= 5000 km/s from the Third Reference Catalog of Bright Galaxies (RC3). We have defined the cutoff Lx for IXOs so that it is well above the Eddington luminosity of a 1.4 Msun black hole (10^38.3 erg/s), so as not to confuse IXOs with ``normal'' black hole X-ray binaries. This catalog is intended to provide a baseline for follow-up work with Chandra and XMM, and with space- and ground-based survey work at wavelengths other than X-ray. We demonstrate that elliptical galaxies with IXOs have a larger number of IXOs per galaxy than non-elliptical galaxies with IXOs, and note that they are not likely to be merely high-mass X-ray binaries with beamed X-ray emission, as may be the case for IXOs in starburst galaxies. Approximately half of the IXOs with multiple observations show X-ray variability, and many (19) of the IXOs have faint optical counterparts in DSS optical B-band images. Follow-up observations of these objects should be helpful in identifying their nature.Comment: 29 pages, ApJS, accepted (catalog v2.0) (full resolution version of paper and future releases of catalog at http://www.xassist.org/ixocat_hri

ROSAT Blank Field Sources I: Sample Selection and Archival Data

We have identified a population of blank field sources (or `blanks') among the ROSAT bright unidentified X-ray sources with faint optical counterparts. The extreme X-ray over optical flux ratio of blanks is not compatible with the main classes of X-ray emitters except for extreme BL Lacertae objects. From the analysis of ROSAT archival data we found no indication of variability and evidence for only three sources, out of 16, needing absorption in excess of the Galactic value. We also found evidence for an extended nature for only one of the 5 blanks with a serendipitous HRI detection; this source (1WGAJ1226.9+3332) was confirmed as a z=0.89 cluster of galaxies. Palomar images reveal the presence of a red (O-E~2) counterpart in the X-ray error circle for 6 blanks. The identification process brought to the discovery of another high z cluster of galaxies, one (possibly extreme) BL Lac, two ultraluminous X-ray sources in nearby galaxies and two apparently normal type1 AGNs. These AGNs, together with 4 more AGN-like objects seem to form a well defined group: they present unabsorbed X-ray spectra but red Palomar counterparts. We discuss the possible explanations for the discrepancy between the X-ray and optical data, among which: a suppressed big blue bump emission, an extreme dust to gas (~40-60 the Galactic ratio), a high redshift (z>3.5) QSO nature, an atypical dust grain size distribution and a dusty warm absorber. These AGN-like blanks seem to be the bright (and easier to study) analogs of the sources which are found in deep Chandra observations. Three more blanks have a still unknown nature.Comment: 23 pages, 8 figures, accepted by ApJ main journa

The Distribution of Redshifts in New Samples of Quasi-stellar Objects

Two new samples of QSOs have been constructed from recent surveys to test the hypothesis that the redshift distribution of bright QSOs is periodic in $\log(1+z)$. The first of these comprises 57 different redshifts among all known close pairs or multiple QSOs, with image separations $\leq$ 10\arcsec, and the second consists of 39 QSOs selected through their X-ray emission and their proximity to bright comparatively nearby active galaxies. The redshift distributions of the samples are found to exhibit distinct peaks with a periodic separation of $\sim 0.089$ in $\log(1+z)$ identical to that claimed in earlier samples but now extended out to higher redshift peaks $z = 2.63, 3.45$ and 4.47, predicted by the formula but never seen before. The periodicity is also seen in a third sample, the 78 QSOs of the 3C and 3CR catalogues. It is present in these three datasets at an overall significance level $10^{-5}$ - $10^{-6}$, and appears not to be explicable by spectroscopic or similar selection effects. Possible interpretations are briefly discussed.Comment: submitted for publication in the Astronomical Journal, 15 figure

The Surroundings of Disturbed, Active Galaxies

The brightest apparent magnitude examples of ultra luminous infrared galaxies (ULIRG's) are studied here in X-ray, optical, infrared and radio wavelengths. It is is found that they have associated material reaching out to apparent diameters of the order of a degree on the sky. Gas, dust, X-ray material and quasars appear to be ejected from the active nuclei with all objects nearer than their redshift distances.Comment: 14 pages, Figs. 1-28 jpg and gif file

An HST Survey of the mid-UV Morphology of Nearby Galaxies

(Abbreviated) We present an imaging survey of 37 nearby galaxies observed with HST/WFPC2 in the mid-UV F300W filter and in F814W. 11 galaxies were also imaged in F255W. These galaxies were selected to be detectable with WFPC2 in one orbit, and cover a wide range of Hubble types and inclinations. The mid-UV spans the gap between our groundbased optical/NIR images and far-UV images available from the Astro/UIT missions. Our first qualitative results are: (1) Early-type galaxies show a significant decrease in surface brightness going from the red to the mid-UV, and in some cases the presence of dust lanes. Some galaxies would be classified different when viewed in the mid-UV, some become dominated by a blue nuclear feature or point source. (2) Half of the mid-type spiral and star-forming galaxies appear as a later morphological type in the mid-UV, as Astro/UIT also found in the far-UV. Some- times these differences are dramatic. The mid-UV images show a considerable range in the scale and surface brightness of individual star-forming regions. Almost all mid-type spirals have their small bulges bi-sected by a dust-lane. (3) Most of the heterogeneous subset of late-type, irregular, peculiar, and merging galaxies display F300W morphologies that are similar to those seen in F814W, but with differences due to recognizable dust features absorbing the bluer light, and due to UV-bright hot stars, star-clusters, and star-forming ridges. In the rest-frame mid-UV, early- to mid-type galaxies are more likely to be misclassified as later types than vice versa. This morphological K-correction explains only part of the excess faint blue galaxies seen in deep HST fields.Comment: 30 pages, LateX (AASTeX5.0), 2 figures and 3 tables included, mid-UV atlas and pan-chromatic atlas provided as 63 JPG figures. Full resolution PS version (~100Mb) available upon request. Accepted for publication in ApJ

Heart failure after pressure overload in autosomal-dominant desminopathies: Lessons from heterozygous DES-p.R349P knock-in mice

Background Mutations in the human desmin gene (DES) cause autosomal-dominant and -recessive cardiomyopathies, leading to heart failure, arrhythmias, and AV blocks. We analyzed the effects of vascular pressure overload in a patient-mimicking p.R349P desmin knock-in mouse model that harbors the orthologue of the frequent human DES missense mutation p. R350P. Methods and results Transverse aortic constriction (TAC) was performed on heterozygous (HET) DES-p.R349P mice and wild-type (WT) littermates. Echocardiography demonstrated reduced left ventricular ejection fraction in HET-TAC (WT-sham: 69.5 ± 2.9%, HET-sham: 64.5 ± 4.7%, WTTAC: 63.5 ± 4.9%, HET-TAC: 55.7 ± 5.4%; p<0.01). Cardiac output was significantly reduced in HET-TAC (WT sham: 13088 ± 2385 μl/min, HET sham: 10391 ± 1349μl/min, WT-TAC: 8097 ± 1903μl/min, HET-TAC: 5793 ± 2517μl/min; p<0.01). Incidence and duration of AV blocks as well as the probability to induce ventricular tachycardias was highest in HET-TAC. We observed reduced mtDNA copy numbers in HET-TAC (WT-sham: 12546 ± 406, HET-sham: 13526 ± 781, WT-TAC: 11155 ± 3315, HET-TAC: 8649 ± 1582; p = 0.025), but no mtDNA deletions. The activity of respiratory chain complexes I and IV showed the greatest reductions in HET-TAC. Conclusion Pressure overload in HET mice aggravated the clinical phenotype of cardiomyopathy and resulted in mitochondrial dysfunction. Preventive avoidance of pressure overload/arterial hypertension in desminopathy patients might represent a crucial therapeutic measure

Oncolytic measles viruses encoding interferon β and the thyroidal sodium iodide symporter gene for mesothelioma virotherapy

Mesothelioma usually leads to death within 8–14 months of diagnosis. To increase the potency of oncolytic measles viruses (MVs) for mesothelioma therapy, we inserted the interferon β (IFNβ) gene alone or with the human thyroidal sodium iodide symporter (NIS) gene into attenuated MV of the Edmonston lineage. The corresponding mouse IFNβ (mIFNβ) viruses, MV-mIFNβ and MV-mIFNβ-NIS, successfully propagated in human mesothelioma cells, leading to intercellular fusion and cell death. High levels of mIFNβ were detected in the supernatants of the infected cells, and radioiodine uptake was substantial in the cells infected with MV-mIFNβ-NIS. MV with mIFNβ expression triggered CD68-positive immune cell infiltration 2–4 times higher than MV-GFP injected into the tumor site. The numbers of CD31-positive vascular endothelial cells within the tumor were decreased at day 7 after intratumoral injection of MV-mIFNβ or MV-mIFNβ-NIS, but not after MV-GFP and PBS administration. Immunohistochemical analysis showed that MV-mIFNβ changed the microenvironment of the mesothelioma by increasing innate immune cell infiltration and inhibiting tumor angiogenesis. Oncolytic MVs coding for IFNβ effectively retarded growth of human mesotheliomas and prolonged survival time in several mesothelioma tumor models. The results suggest that oncolytic MVs that code for IFNβ and NIS will be potent and versatile agents for the treatment of human mesothelioma

Pediatric Measles Vaccine Expressing a Dengue Antigen Induces Durable Serotype-specific Neutralizing Antibodies to Dengue Virus

Dengue disease is an increasing global health problem that threatens one-third of the world's population. Despite decades of efforts, no licensed vaccine against dengue is available. With the aim to develop an affordable vaccine that could be used in young populations living in tropical areas, we evaluated a new strategy based on the expression of a minimal dengue antigen by a vector derived from pediatric live-attenuated Schwarz measles vaccine (MV). As a proof-of-concept, we inserted into the MV vector a sequence encoding a minimal combined dengue antigen composed of the envelope domain III (EDIII) fused to the ectodomain of the membrane protein (ectoM) from DV serotype-1. Immunization of mice susceptible to MV resulted in a long-term production of DV1 serotype-specific neutralizing antibodies. The presence of ectoM was critical to the immunogenicity of inserted EDIII. The adjuvant capacity of ectoM correlated with its ability to promote the maturation of dendritic cells and the secretion of proinflammatory and antiviral cytokines and chemokines involved in adaptive immunity. The protective efficacy of this vaccine should be studied in non-human primates. A combined measles–dengue vaccine might provide a one-shot approach to immunize children against both diseases where they co-exist

Past, Present, and Future X-Ray and Gamma-Ray Missions

X- and -ray astronomy began in the early sixties of the last century with balloons flights, sounding rocket experiment and satellites. Long before space satellite detected X- and -rays emitted by cosmic sources, scientists had known that the Universe should be producing these photons. In this chapter we provided an overview of past and present missions that has made the X- and -ray astronomy an integral part of astronomical research, and prospects of future developments