Clinical features present in carriers of <i>JAG1</i> mutations at the time of hospitalization for neonatal cholestasis and at 3 years of age.

<p>* siblings;</p><p>ERCP, endoscopic retrograde cholangiopancreatography; BA, biliary atresia; BA type 3 –gallbladder, cystic duct and common bile duct are patent; BA type 4 –atresia of all the extrahepatic bile ducts; clinical features were present (+) or missing (-),</p><p>^# indicates clinical features not present at the age of 2 months;</p><p>AGS criteria indicate the number of major clinical features (diagnostic criteria) of Alagille syndrome present at the age of 2 months and 3 years, respectively.</p><p>Clinical features present in carriers of <i>JAG1</i> mutations at the time of hospitalization for neonatal cholestasis and at 3 years of age.</p

Schematic representation of the Jagged1 protein and spliced <i>JAG1</i> mRNA with mutations found in our patients.

<p>Schematic representation of the Jagged1 protein and spliced <i>JAG1</i> mRNA with mutations found in our patients.</p

Mutations in <i>JAG1</i> found in patients with biliary atresia and Alagille syndrome.

<p>* siblings;</p><p>AGS, Alagille syndrome; BA, biliary atresia; novel mutations are in <b>bold</b>.</p><p>Mutations in <i>JAG1</i> found in patients with biliary atresia and Alagille syndrome.</p

Comparison of the BMI of patients with choledocholithiasis who underwent the ERCP procedure (ERCP 1) with that of the control group.

<p>Comparison of the BMI of patients with choledocholithiasis who underwent the ERCP procedure (ERCP 1) with that of the control group.</p

Comparison of patients with cholelithiasis with those in the control group.

<p>Comparison of patients with cholelithiasis with those in the control group.</p

Comparison of the BMI of patients with simple cholelithiasis who did not undergo ERCP (ERCP 0) with that of the control group.

<p>Comparison of the BMI of patients with simple cholelithiasis who did not undergo ERCP (ERCP 0) with that of the control group.</p

Comparison of patients with cholelithiasis with the anthropometric data of the Czech Republic.

<p>Comparison of patients with cholelithiasis with the anthropometric data of the Czech Republic.</p

Cholelithiasis and choledocholithiasis in children; risk factors for development - Fig 1

<p>X-ray during ERCP showing choledocholithiasis (X1) and dilatation of the choledochal duct (X2).</p

Age range of the operated patients.

<p>Age range of the operated patients.</p