9 research outputs found
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
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- Anderson R
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- Andersson L
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- Andres C
- Andresen D
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- Zhao L
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- Zhong H
- Zhong R
- Zhou C
- Zhou Juan
- Zhou Xingyu
- Zhou Yingyuan
- Zhu Wangqin
- Zhu X
- Zhu Y
- Ziefle S
- Zilz N
- Zineldine A
- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Distribution–abundance relationships for North Sea Atlantic cod (Gadus morhua): Observation versus theory
- Author
- Publication venue
- 'Canadian Science Publishing'
- Publication date
- 01/01/2005
- Field of study
Density-dependent habitat selection has implications for fisheries management and for the recovery of depleted fish populations. According to ideal free distribution theory, populations contract into areas of highest habitat suitability as their abundance decreases. This can increase their vulnerability to fishing and predation. We detected density-dependent habitat selection by juvenile Atlantic cod (Gadus morhua) (ages 1 and 2) in the North Sea and compared the observed distribution-abundance relationships with those predicted from a model based on ideal free distribution theory and knowledge of optimal temperatures for growth, where temperature was used as a measure of suitability. As predicted by the model, in years when stock size was low, the catches were largely confined to regions with near-optimal bottom temperatures. Conversely, when population size was high, catches were spread across a larger area including regions with suboptimal temperatures. The spatial extent of optimal habitat appears to have decreased from 1977 to 2002, reflecting a gradual warming of the North Sea. The combined negative effects of increased temperature on recruitment rates and the reduced availability of optimal habitat may have increased the vulnerability of the cod population to fishing mortality
The chromosomes of a catfishParasilurus aristotelis from Greece
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Beyond suffrage: feminism, education and the politics of class in the inter‐war years
- Author
- Banks J.A.
- Banks Olive
- Banks Olive
- Banks Olive
- Barker Rodney
- Bentwich Helen C.
- Bentwich Helen C.
- Bermant Chaim
- Bourdieu Pierre
- Brockway Fenner
- Caine Barbara
- Cole Margaret
- Collini Stefan
- David M.E.
- Donoughue Bernard
- Dyhouse Carol
- Gramsci Antonio
- Harrison Brian
- Jane Martin
- Kamm Josephine
- Kean Hilda
- Key C.W.
- King S.
- Lagemann E.C.
- Lawrence Susan
- Mannheim K.
- Martin Jane
- Miller Jane
- Plant R.
- Rackham Clara D.
- Rousmaniere K.
- Shepherd John
- Simon Brian
- Tawney Richard Henry
- Thom Deborah
- Vallence Elizabeth
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
English agriculturalists’ attitudes towards grassland vegetation, 1780-1914 : an ecological perspective
- Author
- Acland C. T. D.
- Acland C. T. D.
- Ausden M.
- Axford B.
- Bacon J.
- Bartlett M. G.
- Batchelor T.
- Beckett J. V.
- Bettey J. H.
- Billingsley J.
- Blake B.
- Brian A.
- Buckman J.
- Buckman J.
- Carruthers W.
- Carruthers W.
- Cooper M. R.
- Cotterell J. H.
- Crofts A.
- Curtis W. M.
- Duffey E.
- Feltwell J.
- Goddard N.
- Grigg D.
- Grime J. P.
- Hardy T.
- Holland H.
- Hopkins J. J.
- Lane C.
- Locke Mr
- MacDonald S.
- Majendie L.
- Majendie L.
- Marshall Mr
- Marshall Mr
- Marshall Mr
- Marshall W.
- Mingay G. E.
- Pitt W.
- Price D.
- Probably A. Y.
- Rackham O.
- Reay B.
- Rodwell J. S.
- Rowbotham F. J.
- Schröter L.
- Shakespeare W.
- Sheail L.
- Stevenson W.
- Swayne G.
- Swayne G.
- Tanner H.
- Turner E.
- Walker E. G. F.
- Young A.
- Zappa A.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 03/12/2012
- Field of study
Peer reviewe
Psalm 120 and the question of authorship of the songs of Ascents
- Author
- Albright William F.
- Allen Leslie C.
- Amzallag Nissim
- Amzallag Nissim
- Amzallag Nissim
- Amzallag Nissim
- Amzallag Nissim
- Amzallag Nissim
- Amzallag Nissim
- Amzallag Nissim
- Amzallag Nissim
- Barker David G.
- Beaucamp Évode
- Beaulieu Paul-Alain
- Beitzel Barry J.
- Blakely Sandra
- Blenkinsopp Joseph
- Blenkinsopp Joseph
- Booij Thijs
- Brueggemann Walter
- Buttenweiser Moses
- Clifford Richard J.
- Clifford Richard J.
- Condamin Albert
- Crow Loren D.
- Dahood Mitchell
- Dumbrell William J.
- Eliade Mircea
- Finkelstein Israel
- Gerstenberger Erhard S.
- Gilmour Brian
- Girard Marc
- Goulder Michael D.
- Guthrie Harvey H.
- Hossfeld Frank L.
- Hübner Ulrich
- Lehmann Gunther
- Levi-Makarius Laura
- Limburg James
- Longman Tremper
- Martinelli Bruno
- McKenzie Tracy
- McMillon Philip E.
- McNutt Paula M.
- Mondriaan Marleen E.
- Rabinowitz Isaac
- Rackham Harris
- Rainey Anson F.
- Schneider Klaus
- Seybold Klaus
- Tan Nancy
- Tuell Steven S.
- Viviers Hendrick
- Weiser Artur
- West Martin
- Wyatt Nick
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Meadowlands in time: re-envisioning the lost meadows of the Rother valley, West Sussex, UK
- Author
- Baker A. R.
- Baker A. R.
- Bettey J.
- Bettey J.
- Boswell G.
- Bowie G.
- Brandon P.
- Brian A.
- Cook H.
- Cook H.
- Cook H.
- Cox E.
- Cummings I.
- Cutting R.
- Davis T.
- Defra
- Environment Agency
- Environment Agency
- Evans E. J.
- Evans E. J.
- Field J.
- Fitzherbert Sir A.
- Fussell G. E.
- Golden Valley Study Group
- Harley J. B.
- Heywood I.
- Jarvis M. G.
- Kain R. J.
- Kain R. J.
- Kain R. J.
- Kain R. J.
- Kerridge E.
- Kondolf G. M.
- Lewis-Sempel J.
- Lord Leckonfield
- Loudon J. C.
- Marshall W.
- Martins S. W.
- McDonald A.
- McDonald A.
- Pearson A.
- Peterken G.
- Prince H. C.
- Rackham O.
- Sheail J.
- Smith W.
- Sylvester D.
- The National Trust The
- Vamplew W.
- Vaughan R.
- Vine P. A. L.
- Whitehead J.
- Williams M.
- Wright T.
- Wyndham H. A.
- Young A.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
“In the country of my forefathers”
- Author
- Baker Houston A.
- Benson Brian Joseph
- Brantlinger Patrick
- Campbell James T.
- Carby Hazel V.
- Chester Samuel H.
- Chester Samuel H.
- Diedrich Maria
- Du Bois W.E.B.
- Du Bois W.E.B.
- Dworkin Ira
- Edmiston Althea Brown
- Edmiston Althea Brown
- Elliott R. S.
- Franklin John Hope
- Frissell Hollis Burke
- Fülberg-Stolberg Katja
- Gillman Susan
- Gilroy Paul
- Gruesser John Cullen
- Hochschild Adam
- Holt Rackham
- Hopkins Pauline E.
- Hopkins Pauline E.
- Hopkins Pauline E.
- Hopkins Pauline E.
- Hopkins Pauline E.
- Ira Dworkin
- Jacobs Sylvia M.
- Johnson Maggie Pogue
- Kellersberger Julia Lake
- Kennedy Pagan
- Lapsley Samuel N.
- Lewis David Levering
- McHenry Elizabeth
- Otten Thomas J
- Patterson Martha H.
- Phipps William E.
- Pleck Elizabeth Hafkin
- Posnock Ross
- Reynolds David S.
- Rowbotham Arthur
- Schrager Cynthia D.
- Sheppard William H.
- Sheppard William H.
- Sheppard William H.
- Sheppard William H.
- Sheppard William H.
- Stengers Jean
- Twain Mark
- Vansina Jan
- Wallinger Hanna
- Ward Andrew.
- Washington Booker T.
- Wilentz Gay
- Williams Walter L.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Broken Arbour: “The Ruined Cottage” and Deforestation
- Author
- Albion Robert
- Anon
- Artaud Antonin
- Batchelor Thomas
- Bate Jonathan
- Behrendt Stephen
- Beiner Guy
- Bermingham Ann
- Bewell Alan
- Billingsley John
- Buell Lawrence
- Burke Edmund
- Bushaway Bob
- Campbell Mavis C.
- Claridge John
- Collings David
- Crimmin P. K.
- Dallas Robert Charles
- Daniels Stephen
- Everitt Alan
- Flood John
- Foster John Bellamy
- Galeano Eduardo
- Graham G. S.
- Graves Robert
- Hartman Geoffrey
- Hay Douglas
- Herder Johann Gottfried von
- Hess Scott
- Huxley Aldous
- Inglis Brian
- Johnson Leonard George
- Keats John
- King Peter
- Knight R. J. B.
- Lukacs Georg
- Macpherson D
- Marx Karl
- Marx Karl
- Matthew Rowney
- McCalman Iain
- McNeill J. R.
- Morton Timothy
- Nau Ignace
- Perlin John
- Prynne J. H.
- Rackham Oliver
- Rand Frank Prentice
- Richens R. H.
- Rigby Kate
- Roe Nicholas
- Ross Anne
- Said Edward H.
- Schabas Margaret
- Smith Honor Ford
- Spinoza Baruch
- Studnicki-Gizbert Daviken
- Theocritus
- Thompson E. P.
- Trevino Javier A.
- Vitousek P. M.
- Williams Michael
- Wordsworth Dorothy
- Wordsworth William
- Wordsworth William
- Wordsworth William
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study