Optimisation of technological parameters to improve surface quality of continuous cast round billets from C45 steel

Artykuł poświęcony jest zagadnieniu poprawy jakości powierzchni wlewka ciągłego o przekroju Ø 170 mm odlewanego ze stali C45. Poprawę jakości powierzchni można uzyskać sterując wartościami parametrów technologicznych odpowiedzialnych za intensywność smarowania naskórka wlewka w krystalizatorze. Na podstawie doświadczalnego odlewania wytopów ze stali średniowęglowej C45 stwierdzono, że istnieją zależności między parametrami mieszania elekromagnetycznego, właściwościami fizykochemicznymi zasypki krystalizatorowej a intensywnością smarowania naskórka wlewka ciągłego.The article is devoted to the issue of improvement in surface quality of continuous cast round billets of Ø 170 mm mm cast from C45 steel. The surface quality improvement can be obtained by control of process parameters responsible for intensity of round billets lubrication in the mould. Based on the experimental casting of heats from C45 mediumcarbon steel it was found that there were relationships between the electromagnetic stirrer parameters, physicochemical properties of mould powder and intensity of round billet skin lubrication

Clinical course and genetics of syndromic and non-syndromic craniosynostosis

With an incidence of 1:2000-1:3000 births, craniosynostoses are among the most common craniofacial anomalies. Growth inhibition caused by premature fusion of one or more cranial sutures can lead to severe deformities of the skull and facial skeleton. Besides the severe aesthetic problems for the patient, it also has important clinical consequences. These may include raised intracranial pressure, optic nerve atrophy, respiratory, and developmental disorders. Despite major efforts, causative genes (e.g., FGFR1-3, TWIST1) have been detected for only a portion of the autosomal dominantly inherited craniosynostosis syndromes. The etiology of non-syndromic craniosynostosis still remains unclear. The application of next generation sequencing technologies will probably lead to the identification of additional causative genes underlying at the least syndromic forms of craniosynostosis in upcoming years. Due to their clinical complexity, particularly the syndromic forms of craniosynostosis require interdisciplinary care. The only treatment option currently available is craniofacial surgery, which in the long term often fails to remedy the genetically determined pathological growth pattern of complex syndromic craniosynostoses

Installation of the plunger lift and downhole sucker rod pump in gas wells flooded by reservoir water - the results of tests carried out in PGNiG SA Branch in Sanok

W celu poprawy współczynnika sczerpania zawadniających się złóż gazu ziemnego od dwóch lat w oddziale w Sanoku prowadzone są próby usuwania wody z odwiertów przy pomocy gazodźwigu nurnikowego oraz żerdziowej pompy wgłębnej. W referacie przedstawiono wpływ zastosowania tych metod na przebieg wydobycia płynu z odwiertu oraz wprowadzone w trakcie przeprowadzanych testów rozwiązania dostosowujące je do standardowo (dla oddziału) uzbrojonych odwiertów gazowych. Pierwszą metodę zastosowano w niskowydajnym odwiercie, gdzie środki pianotwórcze oraz zwykłe syfonowania nie zapewniły już jego stabilnej eksploatacji. Pompowanie zastosowano w odwiercie całkowicie zawodnionym, przeznaczonym do likwidacji. Pierwsze zebrane doświadczenia potwierdzają efektywność tych sposobów usuwania wody z odwiertów gazowych.In order to improve the ultimate recovery coefficient of water driven natural gas reservoirs, PGNiG Branch in Sanok for two years has been testing the plunger lift equipment and downhole sucker rod pump installations. This paper presents how these methods have affected the fluid production as well as solutions implemented during tests adapted to the standard gas well completion. Plunger lift method was used in a marginal well, where the foaming agents and normal blow out had no longer ensured the stable production. Pumping was utilized in completely flooded gas well, intended for the abandonment. First gained experiences confirm the effectiveness of both methods of gas well de-watering

Nitrilase-catalysed hydrolysis of cyanomethyl p-tolyl sulfoxide: stereochemistry and mechanism

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Synthesis and Evaluation of Biological Activities of Aziridine Derivatives of Urea and Thiourea

In the present paper, we report the synthesis and evaluation of in vitro antimicrobial activities of aziridine-thiourea derivatives. A series of aziridines in reaction with isocyanates and isothiocyanates to obtain urea and thiourea derivatives were used. The structures of all new products were confirmed based on spectroscopic data (1H-NMR, 13C-NMR, HR-MS). These compounds were screened for their in vitro antimicrobial activity against a panel of Gram-positive and Gram-negative strains of bacteria. Six of the tested compounds appeared to be promising agents against reference strains of Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis. Subsequently, compounds exhibiting promising antibacterial activity were tested against twelve clinical isolates of S. aureus from three different sources of infection. The most bactericidal compounds (MIC = 16–32 µg/mL) showed better antibacterial activity against MRSA than ampicillin and streptomycin. The in vitro cytotoxicity analysis on L929 murine fibroblast and HeLa human tumor cell line using the MTT assay allowed us to select the least toxic compounds for future investigation

Lipase-promoted dynamic kinetic resolution of racemic beta-hydroxyalkyl sulfones

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Efficient catalysts for asymmetric Mannich reactions

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An anatomical subunit-based outcome assessment scale for bilateral cleft lip and palate

As there is currently no internationally accepted outcome measurement tool available for complete bilateral cleft lip and palate (CBCLP), the goal of this prospective study was to develop a numerical evaluation scale that allows reliable scoring of this cleft deformity. Our cohort comprised 121 Indian subjects with CBCLP who underwent surgical repair (mean age at time of surgery 6.53 months) using a modified Millard technique. A panel of three professionals evaluated each subject's outcome of bilateral cleft lip repair 6 months postoperatively on two-dimensional (2D) full-face photographs in the frontal view and worm's eye view. A simple two-point rating system was applied to separately analyse a total of 12 components of lip, nose, and scar. The results and mean scores for the analysed anatomical areas were 2.2±1.01 (max=3) for nose, 5.4±1.54 (max=8) for lip, and 1.9±1.3 (max=3) for scar, with a total score 7.7±2.21 (max=12) indicating a good surgical outcome. The inter-examiner ICC for nose, lip, scar, and total score was calculated at 0.836, 0.889, 0.723, and 0.927 respectively and indicated a strong level of repeatability and reliability that was highly significant (P<0.001). In conclusion, we were able to develop and test a scoring system for measuring outcomes in CBCLP that warrants simplicity of use, reliability and reproducibility

The analyze of the power of legs and various types of reaction among the hockey field players at the highest level of sport advance

The aim of the research was to find out the time reaction in a jump after a sound and visual stimulus. Another aim was to define the power of legs among the hockey field players during the pre-season and start season. The result of the hockey field players’ from AZS AWF Poznań and the Polish National Team were the subject of the research, which was carried out twice by the system of optical research – Opto-jump. The somatic and fat measurements were made. The results of the selected group (Polish National Men’s Team) may give the vision of the model of the players their power of the legs, the reaction time at a sound and visual stimulus. Thanks to these results we can compare them with the league team and follow the changes of the parameters level during the training season. In conclusion the training season didn’t have any essential influence on the measured parameters. The Polish Representation results were at far higher level than the league team. We can confirm that the level of the measured features don’t change in a training year