НЕ СВЯЗАННЫE С ВИЧ-ИНФЕКЦИЕЙ ЗАБОЛЕВАНИЯ И ПРИЧИНЫ СМЕРТИ СРЕДИ ВИЧ-ПОЗИТИВНЫХ ПАЦИЕНТОВ В САНКТ-ПЕТЕРБУРГЕ И ЛЕНИНГРАДСКОЙ ОБЛАСТИ

With the aim of an evaluation of the prevalence of non-AIDS-defining illnesses and causes of death in HIVinfected patients 111 medical records of subjects admitted to the specialized hospitals in St. Petersburg in 2001–2008,were analyzed retrospectively. The most frequent non-AIDSdefining illnesses in HIV-infected patients in the era of the absence of the systematical antiretroviral therapy are gastrointestinal diseases. HIV-infected patients mostly die from generalized tuberculosis and chronic viral hepatitis at the End-Stage liver cirrhosis. To properly evaluate the preavalnce of Non-HIV-related diseases and causes of death in HIV-infected people in St. Petersburg and Leningrad region we need to conduct prospective cohort study in comparison with general population.С целью изучения распространенности не связанных с ВИЧ-инфекцией заболеваний и определения основных причин смерти среди больных ВИЧ-инфекцией были ретроспективно оценены 111 историй болезни пациентов, поступивших в специализированные стационары в Санкт-Петербурге за 2001–2008 гг. Наиболее частой сопутствующей патологией среди больных ВИЧ-инфекцией в эру отсутствия широкого применения антиретровирусной терапии являются заболевания желудочно-кишечного тракта. Больные ВИЧ-инфекцией умирают преимущественно от генерализованного туберкулеза и хронических вирусных гепатитов в цирротической стадии. Для полноценной оценки распространенности и спектра не связанных с ВИЧ-инфекцией заболеваний и изучения причин смерти среди ВИЧ-позитивных лиц в Санкт-Петербурге и Ленинградской области необходимо проведение проспективного когортного исследования в сравнении с общей популяцией

Non-AIDS-defining illnesses and causes of death in HIV-infected patients in St. Petersburg and Leningrad Region

With the aim of an evaluation of the prevalence of non-AIDS-defining illnesses and causes of death in HIVinfected patients 111 medical records of subjects admitted to the specialized hospitals in St. Petersburg in 2001–2008,were analyzed retrospectively. The most frequent non-AIDSdefining illnesses in HIV-infected patients in the era of the absence of the systematical antiretroviral therapy are gastrointestinal diseases. HIV-infected patients mostly die from generalized tuberculosis and chronic viral hepatitis at the End-Stage liver cirrhosis. To properly evaluate the preavalnce of Non-HIV-related diseases and causes of death in HIV-infected people in St. Petersburg and Leningrad region we need to conduct prospective cohort study in comparison with general population

Ultrastructural Alterations of Myelinated Fibers and Oligodendrocytes in the Prefrontal Cortex in Schizophrenia: A Postmortem Morphometric Study

Schizophrenia is believed to result from altered neuronal connectivity and impaired myelination. However, there are few direct evidence for myelin abnormalities in schizophrenia. We performed electron microscopic study of myelinated fibers and oligodendrocytes and morphometric study of myelinated fibers in the prefrontal cortex in gray and white matters in schizophrenia and normal controls. Six types of abnormal fibers and ultrastructural alterations of oligodendrocytes were found in schizophrenia. No significant group differences in area density of myelinated fibers were found. Frequency of pathological fibers was increased significantly in gray matter in young and elderly schizophrenia patients and in patients with predominantly positive symptoms. In contrast, in white matter, frequency of altered fibers was increased significantly in elderly patients, in patients with predominantly negative symptoms, and correlated with illness duration. Progressive alterations of myelinated fibers in white matter might be followed by alterations of myelinated fibers in gray matter in schizophrenia