Optimal Cosmic-Ray Detection for Nondestructive Read Ramps

Cosmic rays are a known problem in astronomy, causing both loss of data and data inaccuracy. The problem becomes even more extreme when considering data from a high-radiation environment, such as in orbit around Earth or outside the Earth's magnetic field altogether, unprotected, as will be the case for the James Webb Space Telescope (JWST). For JWST, all the instruments employ nondestructive readout schemes. The most common of these will be "up the ramp" sampling, where the detector is read out regularly during the ramp. We study three methods to correct for cosmic rays in these ramps: a two-point difference method, a deviation from the fit method, and a y-intercept method. We apply these methods to simulated nondestructive read ramps with single-sample groups and varying combinations of flux, number of samples, number of cosmic rays, cosmic-ray location in the exposure, and cosmic-ray strength. We show that the y-intercept method is the optimal detection method in the read-noise-dominated regime, while both the y-intercept method and the two-point difference method are best in the photon-noise-dominated regime, with the latter requiring fewer computations.Comment: To be published in PASP. This paper is 12 pages long and includes 15 figure

High-resolution antenna near-field imaging and sub-THz measurements with a small atomic vapor-cell sensing element

Atomic sensing and measurement of millimeter-wave (mmW) and THz electric fields using quantum-optical EIT spectroscopy of Rydberg states in atomic vapors has garnered significant interest in recent years towards the development of atomic electric-field standards and sensor technologies. Here we describe recent work employing small atomic vapor cell sensing elements for near-field imaging of the radiation pattern of a K$_u$-band horn antenna at 13.49 GHz. We image fields at a spatial resolution of $\lambda/10$ and measure over a 72 to 240 V/m field range using off-resonance AC-Stark shifts of a Rydberg resonance. The same atomic sensing element is used to measure sub-THz electric fields at 255 GHz, an increase in mmW-frequency by more than one order of magnitude. The sub-THz field is measured over a continuous $\pm$100 MHz frequency band using a near-resonant mmW atomic transition

How effective is school-based deworming for the community-wide control of soil-transmitted helminths?

Background: The London Declaration on neglected tropical diseases was based in part on a new World Health Organization roadmap to “sustain, expand and extend drug access programmes to ensure the necessary supply of drugs and other interventions to help control by 2020”. Large drug donations from the pharmaceutical industry form the backbone to this aim, especially for soil-transmitted helminths (STHs) raising the question of how best to use these resources. Deworming for STHs is often targeted at school children because they are at greatest risk of morbidity and because it is remarkably cost-effective. However, the impact of school-based deworming on transmission in the wider community remains unclear. Methods: We first estimate the proportion of parasites targeted by school-based deworming using demography, school enrolment, and data from a small number of example settings where age-specific intensity of infection (either worms or eggs) has been measured for all ages. We also use transmission models to investigate the potential impact of this coverage on transmission for different mixing scenarios. Principal Findings: In the example settings <30% of the population are 5 to <15 years old. Combining this demography with the infection age-intensity profile we estimate that in one setting school children output as little as 15% of hookworm eggs, whereas in another setting they harbour up to 50% of Ascaris lumbricoides worms (the highest proportion of parasites for our examples). In addition, it is estimated that from 40–70% of these children are enrolled at school. Conclusions: These estimates suggest that, whilst school-based programmes have many important benefits, the proportion of infective stages targeted by school-based deworming may be limited, particularly where hookworm predominates. We discuss the consequences for transmission for a range of scenarios, including when infective stages deposited by children are more likely to contribute to transmission than those from adults

Modulation of La Crosse Virus Infection in Aedes albopictus Mosquitoes Following Larval Exposure to Coffee Extracts

The mosquito-borne La Crosse virus (LACV; Family Bunyaviridae) may cause encephalitis, primarily in children, and is distributed throughout much of the eastern United States. No antivirals or vaccines are available for LACV, or most other mosquito-borne viruses, and prevention generally relies on mosquito control. We sought to determine whether coffee extracts could interfere with LACV replication and vector mosquito development. Both regular and decaffeinated coffee demonstrated significant reductions in LACV replication in direct antiviral assays. This activity was not due to the presence of caffeine, which did not inhibit the virus life cycle. Aedes albopictus (Skuse; Diptera: Culicidae) mosquito larvae suffered near total mortality when reared in high concentrations of regular and decaffeinated coffee and in caffeine. Following larval exposure to sublethal coffee concentrations, adult A. albopictus mosquitoes had significantly reduced whole-body LACV titers 5 days post-infection, compared to larvae reared in distilled water. These results suggest that it may be possible to both control mosquito populations and alter the vector competence of mosquitoes for arthropod-borne viruses by introducing antiviral compounds into the larval habitat

Beauty in the Eye of the Producer: The Role of Appearance in the Careers of Hispanic Female Broadcasters

This paper explores the pressures of beauty and appearance on a selected group of female Hispanic broadcast journalists. Ten broadcasters who identify as female and Hispanic were interviewed about their experiences in the industry. A careful analysis indicated that there are pressures for adopting ultra-feminine looks for hair and makeup and sexy clothing for on-air appearances based on consumer feedback. News stations also manage employees’ appearances to maximize favor with audiences and to increase ratings

New g'r'i'z' Photometry of the NGC 5128 Globular Cluster System

We present new photometry for 323 of the globular clusters in NGC 5128 (Centaurus A), measured for the first time in the $g'r'i'z'$ filter system. The color indices are calibrated directly to standard stars in the $g'r'i'z'$ system and are used to establish the fiducial mean colors for the blue and red (low and high metallicity) globular cluster sequences. We also use spectroscopically measured abundances to establish the conversion between the most metallicity-sensitive colors ($(g'-r')_0$, $(g'-i')_0$) and metallicity, [Fe/H].Comment: 14 pages, 9 figures, accepted in A

Promotility Action of the Probiotic Bifidobacterium lactis HN019 Extract Compared with Prucalopride in Isolated Rat Large Intestine

Copyright © 2017 Dalziel, Anderson, Peters, Lynch, Spencer, Dekker and Roy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Attention is increasingly being focussed on probiotics as potential agents to restore or improve gastrointestinal (GI) transit. Determining mechanism of action would support robust health claims. The probiotic bacterium Bifidobacterium lactis HN019 reduces transit time, but its mechanisms of action and effects on motility patterns are poorly understood. The aim of this study was to investigate changes in GI motility induced by an extract of HN019 on distinct patterns of colonic motility in isolated rat large intestine, compared with a known promotility modulator, prucalopride. The large intestines from male Sprague Dawley rats (3–6 months) were perfused with Kreb's buffer at 37°C in an oxygenated tissue bath. Isometric force transducers recorded changes in circular muscle activity at four independent locations assessing contractile propagation between the proximal colon and the rectum. HN019 extract was perfused through the tissue bath and differences in tension and frequency quantified relative to pre-treatment controls. Prucalopride (1 μM) increased the frequency of propagating contractions (by 75 ± 26%) in the majority of preparations studied (10/12), concurrently decreasing the frequency of non-propagating contractions (by 50 ± 11%). HN019 extract had no effect on contractile activity during exposure (n = 8). However, following wash out, contraction amplitude of propagating contractions increased (by 55 ± 18%) in the distal colon, while the frequency of non-propagating proximal contractions decreased by 57 ± 7%. The prokinetic action of prucalopride increased the frequency of synchronous contractions along the length of colon, likely explaining increased colonic rate of transit in vivo. HN019 extract modified motility patterns in a different manner by promoting propagating contractile amplitude and inhibiting non-propagations, also demonstrating prokinetic activity consistent with the reduction of constipation by B. lactis HN019 in humans