ROC curve analysis of the predictive value of single-point 10 am plasma cortisol for adequate or over-replacement as determined by the comparison of pooled AI patients’ cortisol AUC_8–19h to pooled healthy subjects’ cortisol AUC_8–19h.

<p>ROC curve analysis of the predictive value of single-point 10 am plasma cortisol for adequate or over-replacement as determined by the comparison of pooled AI patients’ cortisol AUC_8–19h to pooled healthy subjects’ cortisol AUC_8–19h.</p

Quality of HC replacement dose adjustment in AI patients who underwent three different HC regimens (6, 10 and 14 mg/ m2/d).

<p>AI: adrenal insufficient. HC: hydrocortisone.</p><p>Quality of HC replacement dose adjustment in AI patients who underwent three different HC regimens (6, 10 and 14 mg/ m2/d).</p

The cortisol AUC expressed as mean ± 2 SD (ng/mL/time period) and range values in normal healthy subjects and AI patients.

<p>All statistics are expressed in comparison with control group:</p><p>¹p<0.05,</p><p>²p<0.001.</p><p>AUC: area under curve. AI: adrenal insufficient patients. HC: hydrocortisone.</p><p>The cortisol AUC expressed as mean ± 2 SD (ng/mL/time period) and range values in normal healthy subjects and AI patients.</p

Clinical characteristics of the AI patients.

<p>AI, adrenal insufficiency; APS, autoimmune polyglandular syndrome; HC, hydrocortisone.</p><p>Clinical characteristics of the AI patients.</p

Additional file 1: of Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study

The questionnaire used in the current study. (PDF 620 kb