Vicar Victoria: Writing the Church of England in Nineteenth-Century Fiction

Vicar Victoria: Writing the Church of England in Nineteenth-Century Fiction shows how the organizing force of the Anglican Church and the figure of the Anglican clergyman were used to interrogate social, legal, and historical developments in nineteenth-century fiction. The project outlines how authors reacted to events such as Pluralism reform, the opening of training schools for clergy, and the Oxford Movement. There was a growing importance of institutions (including new physical buildings and Anglican reform movements). Further, the clergy, pushed by the increased expectation to modernize and professionalize, became a specialist career, with raised training and performance requirements. As a result of these internal changes, we find the Anglican Church establishment in a state of flux across the nineteenth century: working to adapt itself to a new normal where Anglicanism as the dominant organizing force in people\u27s lives could no longer be taken for granted

Portraits of Progress: The Rise of Realism in Jane Austen\u27s Clergy

This work examines the development of Austen\u27s characterization of the clergy. It uses examples of three prominent clerical types: Henry Tilney, too good to be true ; William Collins, too ridiculous to be believable ; and Edmund Bertram, realistic because he is both flawed and virtuous. Utilizing critical sources from the last sixty years, this thesis demonstrates that previous scholars have overlooked the idea that the development of Austen\u27s clerical characters can be used to chart Austen\u27s progress as a writer. As such, this thesis fills in where other scholars have left off

The Infectious Diseases BioBank at King's College London: archiving samples from patients infected with HIV to facilitate translational research

The King's College London (KCL) Infectious Diseases BioBank opened in 2007 and collects peripheral venous blood (PVB) from individuals infected with pathogens including human immunodeficiency virus (HIV). PVBs are fractionated into plasmas, lymphocytes and DNA and are then frozen. All donations are from subjects who have given 'open consent' so samples can be used for virtually any type of biomedical research. The HIV component of the BioBank contains samples from over 400 donations from 138 HIV+ patients. Thus, the KCL Infectious Diseases BioBank - together with establishments such as the Spanish HIV BioBank - is likely to expedite translational research into this infection

Keeping PACE With 21st Century Healthcare: A Framework for Telehealth Research, Practice, and Program Evaluation in Occupational Therapy

The use of telehealth to deliver occupational therapy services rapidly expanded during the COVID-19 pandemic. There are frameworks to evaluate services delivered through telehealth; however, none are specific to occupational therapy. Therefore, occupational therapy would benefit from a framework to systematically evaluate components of telehealth service delivery and build evidence to demonstrate the distinct value of occupational therapy.  The PACE Framework outlines four priority domains to address areas of need: (1) Population and Health Outcomes; (2) Access for All Clients; (3) Costs and Cost Effectiveness; and (4) Experiences of Clients and Occupational Therapy Practitioners. This article describes the development and expert reviewer evaluation of the PACE Framework. In addition, the PACE Framework’s domains, subdomains, and outcome measure examples are described along with future directions for implementation in occupational therapy research, practice, and program evaluation.&nbsp

Genetics of Childhood Steroid Sensitive Nephrotic Syndrome: An Update

Advances in genome science in the last 20 years have led to the discovery of over 50 single gene causes and genetic risk loci for steroid resistant nephrotic syndrome (SRNS). Despite these advances, the genetic architecture of childhood steroid sensitive nephrotic syndrome (SSNS) remains poorly understood due in large part to the varying clinical course of SSNS over time. Recent exome and genome wide association studies from well-defined cohorts of children with SSNS identified variants in multiple MHC class II molecules such as HLA-DQA1 and HLA-DQB1 as risk factors for SSNS, thus stressing the central role of adaptive immunity in the pathogenesis of SSNS. However, evidence suggests that unknown second hit risk loci outside of the MHC locus and environmental factors also make significant contributions to disease. In this review, we examine what is currently known about the genetics of SSNS, the implications of recent findings on our understanding of pathogenesis of SSNS, and how we can utilize these results and findings from future studies to improve the management of children with nephrotic syndrome

Genetic risk variants for childhood nephrotic syndrome and corticosteroid response

IntroductionThe etiology of most cases of nephrotic syndrome (NS) remains unknown, therefore patients are phenotypically categorized based on response to corticosteroid therapy as steroid sensitive NS (SSNS), or steroid resistant NS (SRNS). Genetic risk factors have been identified for SSNS from unbiased genome-wide association studies (GWAS), however it is unclear if these loci are disease risk loci in other forms of NS such as SRNS. Additionally, it remains unknown if these risk loci are associated with response to therapy. Thus, we investigated the association between SSNS risk loci and therapy response in a large, multi-race cohort of children along the entire spectrum of childhood-onset NS.MethodsWe enrolled 1,000 patients with childhood-onset NS comprised of SSNS and SRNS. Genotyping was done using TaqMan and Direct Sanger Sequencing for 9 previously reported childhood SSNS risk loci. We compared the allele frequencies (AF) and variant burden between NS vs. controls and SRNS vs. SSNS.ResultsAll 9 risk loci were associated with NS compared with healthy controls (p = 3.5 × 10−3–<2.2 × 10−16). Variant burden greater than 7 was associated with risk of SRNS (OR 7.4, 95% CI 4.6–12.0, p = 8.2 × 10−16).ConclusionOur study showed that genetic risk loci for childhood SSNS are associated with pattern of therapy response, may help predict disease outcome, and set the stage for individualized treatment of NS

Social Preferences and Moral Biases

An emerging consensus in economics is that three motives are at work in strategic decisions: distributive preferences, reciprocal preferences and self-interest. An important obstacle, however, has been moral biases: distortions created by self-interest can obscure our measures of social preferences. This paper describes a simple experiment to address this. We compare the decisions of implicated “stakeholders” with those of impartial “spectators.” We find that stakeholders are less inclined to respond to the generosity of others than are spectators. We also clarify a result in previous research (e.g., Offerman 2002) that stakeholders punish unkindness more than they reward kindness. We find that this asymmetry in reciprocity has two sources: an asymmetry in the underlying preference that even impartial spectators display and a moral bias; stakeholders punish more and reward less than spectators. In sum, we find that all three motives have important and significant effects on final allocations

Do the Selfish Mimic Cooperators? Experimental Evidence from Finitely-Repeated Labor Markets

Experimental studies have consistently shown that cooperative outcomes can emerge even in finitely repeated games. Such outcomes are justified by existing reputation building models, which suggest that cooperative outcomes can be sustained if some subjects have other-regarding preferences. While the existence of other-regarding preferences is typically used to justify experimental outcomes, we are unaware of empirical studies that explicitly examine the interaction between cooperators (those with other-regarding preferences) and selfish subjects in sustaining cooperation. In this paper, we classify subjects as either selfish or cooperative using simple social preference games and then test for behavioral differences between the two types in a finitely-repeated labor market with unenforceable worker effort. Theory predicts, and our data confirms, that (1) selfish players mimic the actions of cooperators when trading partners can track the individual reputation of past partners and (2) selfish and cooperative types act differently when individual reputations cannot be tracked