267 research outputs found
A case of large leiomyoma arising from rudimentary horn in Mayer Rokitansky-KĆ¼ster-Hauser syndrome, managed by minimally invasive surgery
Mayer-Rokitansky-KĆ¼ster-Hauser (MRKH) syndrome is a congenital disorder marked by aplasia or hypoplasia of the uterus and vagina as a result of arrest in the development of the mĆ¼llerian ducts. Prevalence being 1 in 4000ā5000 live births of females. Leiomyoma is the most common uterine tumor, their occurrence from rudimentary uterus in females with MRKH syndrome is very rare and only a few cases have been documented in the literature. Here we report a 38-year-old female, known case of MRKH syndrome presenting with USG suggestive of 7.9x7.4x6.0 leiomyoma in proximity to the hypoplastic uterus, undergoing a laparoscopic removal of fibroid with right ovarian cystectomy (incidental finding). Therefore, it is important to consider such unusual diagnosis of fibroids originating from primitive horns while treating these patients for gynecological symptoms as well as infertility, and consider them managing endoscopically
Reproductive potential in a case of Mosaic Turners syndrome with 46XY karyotype
This article describes a case of 18year-old-female who presented with primary amenorrhea, phenotypic features of Turners syndrome, which was confirmed later by Karyotype to have mosaic 45XO(8)/46XY(22). She had delayed puberty and proved (hormonally) to have ovarian failure, with absent Mullerian structures (radiologically and laparoscopy)
Formation of iron nitride thin films with Al and Ti additives
In this work we investigate the process of iron nitride (Fe-N) phase
formation using 2 at.% Al or 2 at.% Ti as additives. The samples were prepared
with a magnetron sputtering technique using different amount of nitrogen during
the deposition process. The nitrogen partial pressure (\pn) was varied between
0-50% (rest Argon) and the targets of pure Fe, [Fe+Ti] and [Fe+Al] were
sputtered. The addition of small amount of Ti or Al results in improved
soft-magnetic properties when sputtered using \pn 10\p. When \pn is
increased to 50\p non-magnetic Fe-N phases are formed. We found that iron
mononitride (FeN) phases (N at% 50) are formed with Al or Ti addition at
\pn =50% whereas in absence of such addition \eFeN phases (N\pat30) are
formed. It was found that the overall nitrogen content can be increased
significantly with Al or Ti additions. On the basis of obtained result we
propose a mechanism describing formation of Fe-N phases Al and Ti additives.Comment: 9 Pages, 7 Figure
Human islets expressing HNF1A variant have defective beta cell transcriptional regulatory networks
Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained beta cells without insulitis and lacked glucose-stimulated insulin secretion despite a normal insulin response to cAMP-evoked stimulation. With these unexpected findings for T1D, we sequenced the donor DNA and found a pathogenic heterozygous variant in the gene encoding hepatocyte nuclear factor-1alpha (HNF1A). In one of the first studies of human pancreatic islets with a disease-causing HNF1A variant associated with the most common form of monogenic diabetes, we found that HNF1A dysfunction leads to insulin-insufficient diabetes reminiscent of T1D by impacting the regulatory processes critical for glucose-stimulated insulin secretion and suggest a rationale for a therapeutic alternative to current treatment
Clinical Significance of Telomere Length and Associated Proteins in Oral Cancer
Purpose: Telomere shortening is an important event during carcinogenesis. Although studies suggest role of multiple proteins in telomere length regulation, there is dearth of reports in oral cancer which is a leading malignancy in Asian countries especially in India. Thus the present study was carried out to study these mechanisms and explore the pathways involved in telomereātelomerase regulation and identify possible prognostic markers to understand the biology of oral tumors for better treatment approaches. Methods: Telomere length was determined by Southern Hybridisation method, telomeric repeat binding factor (TRF) 1 and 2 expression was detected by Western blot method and telomerase activation by telomeric repeat amplifi cation protocol. Statistical analysis was done using SPSS (Version 10) software. Results: Significant shortening of telomeres was seen in the tumor tissues as compared to normal tissues. Poor prognosis was observed in the patients with higher telomere length in malignant tissue, higher tumor to normal telomere length ratio (T/N TRF LR). Expression of TRF-2 but not TRF-1 protein was signifi cantly higher in the malignant tissues. We also observed telomerase activation in 75 malignant tissues.Conclusions: Our results reveal signifi cant clinical usefulness of telomere length, T/N TRF LR and telomerase activation in the prognosis of oral cancer patients. TRF-2 overexpression in malignant tissues appears to play an important role in telomere length shortening in oral cancer. Abbreviations: TRFāTerminal restriction fragment; TRF-1ātelomeric repeat binding factor-1; TRF-2ātelomeric repeat binding factor-2; T/N TRF LRāTumor/ Normal TRF length ratio
Nanocrystallization and Amorphization Induced by Reactive Nitrogen Sputtering in Iron and Permalloy
Thin films of iron and permalloy Ni80Fe20 were prepared using an Ar+N2
mixture with magnetron sputtering technique at ambient temperature. The
nitrogen partial pressure, during sputtering process was varied in the range of
0 to 100%, keeping the total gas flow at constant. At lower nitrogen pressures
RN2<33% both Fe and NiFe, first form a nanocrystalline structure and an
increase in nitrogen partail pressure results in formation of an amorphous
structure. At intermediate nitrogen partial pressures, nitrides of Fe and NiFe
were obtained while at even higher nitrogen partial pressures, nitrides
themselves became nanocrystalline or amorphous. The surface, structural and
magnetic properties of the deposited films were studied using x-ray reflection
and diffraction, transmission electron microscopy, polarized neutron
reflectivity and using a DC extraction magnetometer. The growth behavior for
amorphous film was found different as compared with poly or nanocrystalline
films. The soft-magnetic properties of FeN were improved on nanocrystallization
while those of NiFeN were degraded. A mechanism inducing nanocrystallization
and amorphization in Fe and NiFe due to reactive nitrogen sputtering is
discussed in the present article.Comment: 13 Pages, 15 Figure
Multifactorial Aspects of Adiponectin in Non- Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is a significant worldwide health issue strongly associated with obesity and metabolic syndrome. It underscores the critical role of adiponectin, a significant adipokine, in the disease's intricate progression. NAFLD's complexity stems from its interplay with factors like obesity, diabetes, and metabolic syndrome, with reduced adiponectin levels commonly observed in NAFLD patients, influenced by age, gender, lipid profiles, and insulin resistance. Adiponectin's versatility in mitigating insulin resistance, inflammation, and liver fibrosis makes it a focal point in NAFLD research, while recent studies introduce spexin, a neuropeptide, as a potential correlate, adding to the understanding of metabolic disorders. To tailor treatment approaches, recognizing the factors affecting adiponectin levels, such as genetics, lifestyle, and comorbidities, is crucial. Lifestyle changes and specific medications offer promise in improving NAFLD outcomes by modulating adiponectin. The article underscores adiponectin's central role in the complex NAFLD landscape and the need for further research to fully grasp its mechanisms and therapeutic potential in managing this prevalent liver disease, emphasizing the importance of rebalancing adipokines and enhancing metabolic health
Multifactorial Aspects Influencing Non-Alcoholic Fatty Liver Disease (Nafld)
Nonalcoholic fatty liver disease (NAFLD) is a growing public health concern, with a prevalence of up to 25% worldwide. While once considered a benign condition, NAFLD is now recognized as a major cause of chronic liver disease, liver failure, and hepatocellular carcinoma. The pathogenesis of NAFLD is multifactorial and involves a complex interplay between genetic, environmental, and metabolic factors. In this review, we provide an overview of the multifactorial aspects of NAFLD, including genetic predisposition, insulin resistance, dyslipidemia, gut microbiota, dietary factors, and physical inactivity. We also discuss the role of inflammation, oxidative stress, and hepatic steatosis in the progression of NAFLD to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Finally, we review the current and emerging therapies for NAFLD and NASH, including lifestyle modifications, pharmacological interventions, and surgical approaches. The multifactorial nature of NAFLD requires a comprehensive approach to diagnosis, treatment, and prevention, with a focus on addressing the underlying metabolic and environmental factors that contribute to its development and progression
Optimization of Biogenic Synthesis of Colloidal Metal Nanoparticles
Nanotechnology which deals with the synthesis and characterization of dispersed or solid particles in nano-metric range has emerged out to be a novel approach due to its ample applications in biomedical fields. The advancements in the field of nanotechnology and substantial evidences in biomedical applications have led the researchers to explore safe, ecofriendly, rapid and sustainable approaches for the synthesis of colloidal metal nanoparticles. This chapter illustrates superiority of biogenic route of synthesis of nanoparticles over the different approaches such as chemical and physical methods. In biogenic route, plants and microorganisms like algae, fungi, yeast, actinomycetes etc. act as ābio-factoriesā which reduce the metal precursors and play a crucial role in the synthesis of nanoparticles with distinct morphologies. Thus, the need of hazardous chemicals is eliminated and a safer and greener approach of nanoparticles synthesis can be adopted. This chapter also outlines the effect of optimization of different parameters mainly pH, temperature, time and concentration of metal ions on the nanoparticle synthesis. It is evident that the optimization of various parameters can yield nanoparticles with desired properties suitable for respective biomedical applications
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