4,803 research outputs found
Black Hole Radiation and Volume Statistical Entropy
The simplest possible equation for Hawking radiation, and other black hole
radiated power is derived in terms of black hole density. Black hole density
also leads to the simplest possible model of a gas of elementary constituents
confined inside a gravitational bottle of Schwarzchild radius at tremendous
pressure, which yields identically the same functional dependence as the
traditional black hole entropy. Variations of Sbh can be obtained which depend
on the occupancy of phase space cells. A relation is derived between the
constituent momenta and the black hole radius which is similar to the Compton
wavelength relation.Comment: 11 pages, no figures. Key Words: Black Hole Entropy, Hawking
Radiation, Black Hole density. This is a better pdf versio
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Person-Specific Methods for Characterizing the Course and Temporal Dynamics of Concussion Symptomatology: A Pilot Study.
Better characterization of acute concussion symptomatology is needed in order to advance clinical and scientific understanding of persistent concussion symptoms. This paper aims to illustrate a novel framework for conceptualizing, collecting, and analyzing concussion symptom data. To that end, we describe the temporal and structural dynamics of acute concussion symptoms at the individual-patient level. Ten recently concussion adolescents and young adults completed 20 days of ecological momentary assessment (EMA) of post-concussion symptoms. Follow-up assessments were completed at 3 months post-injury. Network modeling revealed marked heterogeneity across participants. In the overall sample, temporal patterns explained the most variance in light sensitivity (48%) and the least variance in vomiting (5%). About half of the participants had symptom networks that were sparse after controlling for temporal variation. The other individualized symptom networks were densely interconnected clusters of symptoms. Networks were highly idiosyncratic in nature, yet emotional symptoms (nervousness, emotional, sadness), cognitive symptoms (mental fogginess, slowness), and symptoms of hyperacusis (sensitivity to light, sensitivity to noise) tended to cluster together across participants. Person-specific analytic techniques revealed a number of idiosyncratic features of post-concussion symptomatology. We propose applying this framework to future research to better understand individual differences in concussion recovery
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Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
Background
Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly derived from glucose. In hypoxia, however, flux from glucose to acetyl-CoA decreases, and the fractional contribution of glutamine to acetyl-CoA increases. The significance of other acetyl-CoA sources, however, has not been rigorously evaluated. Here we investigate quantitatively, using 13C-tracers and mass spectrometry, the sources of acetyl-CoA in hypoxia.<p></p>
Results
In normoxic conditions, cultured cells produced more than 90% of acetyl-CoA from glucose and glutamine-derived carbon. In hypoxic cells, this contribution dropped, ranging across cell lines from 50% to 80%. Thus, under hypoxia, one or more additional substrates significantly contribute to acetyl-CoA production. 13C-tracer experiments revealed that neither amino acids nor fatty acids are the primary source of this acetyl-CoA. Instead, the main additional source is acetate. A large contribution from acetate occurs despite it being present in the medium at a low concentration (50–500 μM).<p></p>
Conclusions
Acetate is an important source of acetyl-CoA in hypoxia. Inhibition of acetate metabolism may impair tumor growth.<p></p>
Nuclear Magnetohydrodynamic EMP, Solar Storms, and Substorms
In addition to a fast electromagnetic pulse (EMP), a high altitude nuclear
burst produces a relatively slow magnetohydrodynarnic EMP (MHD EMP), whose
effects are like those from solar storm geomagnetically induced currents (SS
GIC). The MHD EMP electric field E < 10^-1 V/m and lasts < 10^2 sec, whereas
for solar storms E > 10^-2 V/m and lasts >10^3 sec. Although the solar storm
electric field is lower than MHD EMP, the solar storm effects are generally
greater due to their much longer duration. Substorms produce much smaller
effects than SS GIC, but occur much more frequently. This paper describes the
physics of such geomagnetic disturbances and analyzes their effects.Comment: 29 pages, 14 figures, 5 table
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