2 research outputs found
Promocijas darbs
Get PDFElektroniskÄ versija nesatur pielikumusLatvijÄ ir augsta Helicobacter pylori (H. pylori) infekcijas un ar to saistÄ«-tÄs kuÅÄ£a gļotÄdas atrofijas un kuÅÄ£a vÄža izplatÄ«ba. Lai gan lÄ«dz pat 89% no ne-kardijas kuÅÄ£a vÄža gadÄ«jumiem pasaulÄ saistÄ«ti ar H. pylori, vairumam cilvÄku ar Å”o infekciju kuÅÄ£a vÄzis dzÄ«ves laikÄ neattÄ«stÄ«sies. Å is apstÄklis atstÄj vietu virknei citu faktoru, kuriem varÄtu bÅ«t svarÄ«ga loma kuÅÄ£a priekÅ”vÄža stÄvokļu attÄ«stÄ«bÄ. PepsinogÄnu noteikÅ”ana serumÄ ir labÄkÄ Å”obrÄ«d pieejamÄ neinvazÄ«vÄ metode kuÅÄ£a gļotÄdas stÄvokļa izzinÄÅ”anai. TomÄr pepsinogÄniem piemÄ«t mÄrena diagnostiska nozÄ«me kuÅÄ£a priekÅ”vÄža stÄvokļu noteikÅ”anÄ un pÄtÄ«jumos vÄrojama bÅ«tiska datu atŔķirÄ«ba, kas varÄtu bÅ«t saistÄ«ta ar dažÄdu populÄciju Ä«patnÄ«bÄm. Nav pieejami liela mÄroga pÄtÄ«jumi par to, vai balstoties uz konkrÄtiem populÄcijas faktoriem varÄtu pielÄgot un uzlabot pepsinogÄnu diagnostiku.Balstoties uz iepriekÅ”minÄtajiem apstÄkļiem, izvirzÄ«ts darba virsmÄrÄ·is, kura sasniegÅ”ana varÄtu dot klÄ«niski izmantojamu pienesumu ā izstrÄdÄt populÄcijai pielÄgotu pieeju kuÅÄ£a priekÅ”vÄža stÄvokļu seroloÄ£iskÄ skrÄ«ninga uzlaboÅ”anai, identificÄjot ar H. pylori un kuÅÄ£a atrofijas izplatÄ«bu saistÄ«tus socioekonomiskus un dzÄ«vesveida faktorus un lÄ«dz ar to populÄcijas riska grupasLatvia has a high prevalence of Helicobacter pylori (H. pylori), as well as conditions associated with the infection ā atrophy of the gastric mucosa and stomach cancer. Although up to 89% of non-cardia gastric cancer cases in the world are attributable to H. pylori, most people with the infection will not develop gastric cancer during their lifetime. This leaves room for a number of other factors that could play an important role in the development of precance-rous gastric lesions. The detection of pepsinogens in serum is the best currently available non-invasive method for assessing the condition of the gastric mucosa. However, studies show that pepsinogens have a moderate diagnostic yield in identifying precancerous gastric lesions with heterogenous results, which could be due to population specific differences. There are no large scale studies pub-lished on whether pepsinogen testing could be adapted and improved based on specific population factors.Based on the abovementioned circumstances, the aim of the thesis was to develop a population tailored approach to improve serological screening for pre-cancerous gastric lesions by identifying the socioeconomic and lifestyle factors associated with the prevalence of H. pylori and gastric atrophy, so identifying risk groups in the population. This would result in clinically applicable fnding
Iodine deficiency during pregnancy in a regional context and its influence on intellectual development of school children in Latvia
No full textLatvijÄ ilgstoÅ”i pastÄv joda deficÄ«ts, kas ir bÄ«stams sabiedrÄ«bas veselÄ«bai un intelektuÄlajai attÄ«stÄ«bai. Pat neliels joda deficÄ«ts grÅ«tniecÄ«bas periodÄ izraisa bÄrna IQ pazeminÄÅ”anos, lÄ«dz ar to vÄlÄk arÄ« iespÄjamu valsts IKP per capita samazinÄÅ”anos.
Uzdevumi: izvÄrtÄt joda pietiekamÄ«bu Latvijas grÅ«tniecÄm reÄ£ionÄlÄ griezumÄ, sakarÄ«bas ar saistÄ«tiem faktoriem, kÄ arÄ« censties identificÄt sakarÄ«bu starp joda koncentrÄciju urÄ«nÄ (JU) skolÄniem un atzÄ«mÄm valsts eksÄmenos.
Visos Latvijas reÄ£ionos grÅ«tniecÄm konstatÄts joda deficÄ«ts (mediÄnÄ JU 64.5-89.9 Āµg/g Cr). Starp grÅ«tnieÄu JU un jodu saturoÅ”u vitamÄ«nu lietoÅ”anu statistiski ticama sakarÄ«ba atrasta tikai ZemgalÄ, bet ar jodsÄls lietoÅ”anu nav atrasta. RezultÄti norÄda uz esoÅ”o joda uzÅemÅ”anas veidu nepietiekamo efektivitÄti joda deficÄ«ta novÄrÅ”anÄ grÅ«tniecÄm LatvijÄ. IezÄ«mÄjas iespÄjama tendence starp joda deficÄ«tu skolÄniem un zemÄkÄm atzÄ«mÄm.Iodine deficiency remains a problem in Latvia, detrimental to the health and intellectual development of the community. Even mild iodine deficiency during pregnancy causes a decrease in child IQ, later possibly resulting in a decline in per capita GDP.
Objectives: evaluate the iodine status of pregnant women in Latvia from a regional perspective, relationships between urinary iodine concentration (UIC) and related factors, and try to identify a relationship between UIC of school children and state exam grades.
Pregnant women were found to be iodine deficient in all regions of Latvia (median UIC 64.5-89.9 Āµg/g Cr). Statistically significant relationship was found between UIC in pregnancy and iodine containing vitamin use only in Zemgale, but with iodized salt use was not found. Results indicate that the current methods of iodine uptake are not sufficient to effectively avert iodine deficiency during pregnancy in Latvia. A possible tendency was observed between iodine deficiency in school children and lower state exam grades
