The rural press in Kansas

Thesis (M.A.)--University of Kansas, Journalism, 1932

The Effect of Elevated Temperature on the Inelastic Deformation Behavior of PMR-15 Solid Polymer

The inelastic deformation behavior of PMR-15 neat resin, a high-temperature thermoset polymer, was investigated at temperatures in the 274-316°C range. The experimental program was developed to explore the influence of temperature on tensile loading, relaxation and creep behaviors of PMR-15. The results demonstrate that the mechanical behavior of PMR-15 exhibits a strong dependence on temperature. During strain-controlled tensile loading, the slope of the stress-strain curve in the quasi-elastic region decreases and the flow stress level decreases with increasing temperature. During relaxation, the amount of the stress drop decreases with increasing temperature. Based on experimental results the Viscoplasticity Based on Overstress for Polymers theory was augmented to account for the effects of elevated temperature. Several model parameters were developed into functions of temperature. The augmented VBOP was then employed to predict the response of the PMR-15 polymer under various test histories at temperatures in the 274-316°C range. Additionally, the effects of prior isothermal aging at various temperatures in the 260-316°C range were evaluated. At each temperature investigated, the initial slope of the stress-strain curve and the flow stress increase with prior aging duration. Experimental results reveal for aging temperatures in the 260-302°C range, mechanical behavior depends only on prior aging duration and not on prior aging temperature

Report no. 1 : Anton Bruun cruise A : Aden-Bombay, February-March, 1963

En route from the U. S. to Bombay, India during February - March, 1963 an unscheduled oceanographic section of 13 stations was made in the Arabian Sea between Aden and Bombay. Standard hydrographic casts were made to 1400 meters indicated depth (1000 meters at Stations 1-3) for meas9rement of temperature, salinity, dissolved oxygen, phosphate, nitrite, nitrate and silicate. A large, plastic sampler was used to obtain water samples from depths corresponding to 100, 50, 25, 10 and 1% of the sunlight incident to the surface. These samples were used for measurement of primary productivity (C-14 method), phytoplankton pigments, particulate carbon, nitrogen and phosphorus

The role of local inpatient psychiatric units and general practitioner on continuity of care in Northern Norway: A case-register study

Objectives: The general practitioners' (GP) role in the care of mental health patients has received increased attention. The literature underlines the need for integration of primary and specialist services, but cross-boundary continuity for patients with severe conditions may be particularly poor. The aim of this study was to analyze the collaboration between primary care and different models of specialized psychiatric services for patients with severe conditions. Methods: We compared a local and a centralized model of mental health care. Service utilization over a 5-year period was studied. Results: Findings suggest that a local institution-based model of services positively affects the use of both GP and specialist outpatient care, with most inpatients utilizing both GP and specialist outpatient consultations. In the centralized model, a substantial proportion of inpatients only used GP outpatient care. Furthermore, inpatients that used both GP and specialist outpatient services received more of both services compared to those who did not enter specialist outpatient care at all. Conclusion: Local inpatient units may positively affect continuity of care and collaboration between general practitioners and specialist psychiatric services compared to more traditional hospital units, probably because better functional integration of services, better facilitation of clinical alliances/relationships, or a more network-oriented treatment philosophy.publishedVersio

Analysis of X-inactivation status in a Rett syndrome natural history study cohort

BACKGROUND: Rett syndrome (RTT) is a rare neurodevelopmental disorder associated with pathogenic MECP2 variants. Because the MECP2 gene is subject to X-chromosome inactivation (XCI), factors including MECP2 genotypic variation, tissue differences in XCI, and skewing of XCI all likely contribute to the clinical severity of individuals with RTT. METHODS: We analyzed the XCI patterns from blood samples of 320 individuals and their mothers. It includes individuals with RTT (n = 287) and other syndromes sharing overlapping phenotypes with RTT (such as CDKL5 Deficiency Disorder [CDD, n = 16]). XCI status in each proband/mother duo and the parental origin of the preferentially inactivated X chromosome were analyzed. RESULTS: The average XCI ratio in probands was slightly increased compared to their unaffected mothers (73% vs. 69%, p = .0006). Among the duos with informative XCI data, the majority of individuals with classic RTT had their paternal allele preferentially inactivated (n = 180/220, 82%). In sharp contrast, individuals with CDD had their maternal allele preferentially inactivated (n = 10/12, 83%). Our data indicate a weak positive correlation between XCI skewing ratio and clinical severity scale (CSS) scores in classic RTT patients with maternal allele preferentially inactivated XCI (r CONCLUSION: These results extend our understanding of the pathogenesis of RTT and other syndromes with overlapping clinical features by providing insight into the both XCI and the preferential XCI of parental alleles

Anxiety-like behavior and anxiolytic treatment in the Rett syndrome natural history study

BACKGROUND: Rett syndrome (RTT) is a neurodevelopmental disorder most often related to a pathogenic variant in the X-linked MECP2 gene. Internalizing behaviors appear to be common, but standard methods of diagnosing anxiety are not readily applied in this population which typically has cognitive impairment and limited expressive language. This study aims to describe the frequency of anxiety-like behavior and anxiolytic treatments along with associated clinical features in individuals with RTT. METHODS: Parental reports and medication logs provided data from 1380 females with RTT participating in two iterations of the multicenter U.S. RTT Natural History Study (RNHS) from 2006 to 2019. RESULTS: Most participants with RTT (77.5%) had at least occasional anxious or nervous behavior. Anxiety was reported to be the most troublesome concern for 2.6%, and within the top 3 concerns for 10.0%, of participants in the second iteration. Parents directly reported treatment for anxious or nervous behavior in 16.6% of participants in the second iteration with most reporting good control of the behavior (71.6%). In the medication logs of both RNHS iterations, the indication of anxiety was listed for a similar number of participants (15% and 14.5%, respectively). Increased use of anxiolytics and selective serotonin reuptake inhibitors (SSRIs) was related to more frequent anxiety-like behaviors (P \u3c 0.001), older age (P \u3c 0.001), and mild MECP2 variants (P = 0.002). CONCLUSION: Anxiety-like behavior is frequent at all ages and is a significant parental concern in RTT. Older individuals and those with mild MECP2 variants are more likely to be treated with medications. Better diagnosis and treatment of anxiety in RTT should be a goal of both future studies and clinical care. TRIAL REGISTRATION: NCT00299312 and NCT02738281

Influence of the Amazon River outflow on the ecology of the western tropical Atlantic I. Hydrography and nutrient chemistry

The influence of the Amazon River discharge on the nutrient chemistry and biological productivity in the western tropical Atlantic and the eastern Caribbean was investigated during two oceanogr aphic cruises in the fall of 1964 and the spring of 1965, respectively. The river outflow is entrained in the Guiana Current and carried to the north and east, affecting an area that is at times a million square miles, as indicated by surface salinity...