AGA Clinical Practice Update on interventional EUS for vascular investigation and therapy: Commentary

DESCRIPTION: The purpose of this AGA Institute Clinical Practice Update is to review the available evidence supporting and examine opportunities for future research in endoscopic ultrasound-guided vascular investigation and therapies. METHODS: This Clinical Practice Update was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. This expert commentary incorporates important as well as recently published studies in this field, and it reflects the experiences of the authors who are advanced endoscopists with expertise in endoscopic ultrasound-guided vascular investigation and therapy

Heterotic Action in SUGRA-SYM Background

We consider the generalization of the heterotic action considered by Cherkis and Schwarz where the chiral bosons are introduced in a manifestly covariant way using an auxiliary field. In particular, we construct the kappa-symmetric heterotic action in ten-dimensional supergravity background coupled to super Yang-Mills theory and prove its kappa-symmetry. The usual Bianchi identity of Type I supergravity with super Yang-Mills dH_3= -\tr F\wedge F is crucially used. For technical reason, the Yang-Mills field is restricted to be abelian.Comment: 12 pages, no figures, added comments in the acknowledgmen

Energetic Particles Dynamics in Mercury's Magnetosphere

We investigate the drift paths of energetic particles in Mercury's magnetosphere by tracing their motion through a model magnetic field. Test particle simulations solving the full Lorentz force show a quasi-trapped energetic particle population that gradient and curvature drift around the planet via "Shabansky" orbits, passing though high latitudes in the compressed dayside by equatorial latitudes on the nightside. Due to their large gyroradii, energetic H+ and Na+ ions will typically collide with the planet or the magnetopause and will not be able to complete a full drift orbit. These simulations provide direct comparison for recent spacecraft measurements from MESSENGER. Mercury's offset dipole results in an asymmetric loss cone and therefore an asymmetry in particle precipitation with more particles precipitating in the southern hemisphere. Since the planet lacks an atmosphere, precipitating particles will collide directly with the surface of the planet. The incident charged particles can kick up neutrals from the surface and have implications for the formation of the exosphere and weathering of the surfac

Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

Gene expression systems that allow the regulation of bacterial genes during an infection are valuable molecular tools but are lacking for mycobacterial pathogens. We report the development of mycobacterial gene regulation systems that allow controlling gene expression in fast and slow-growing mycobacteria, including Mycobacterium tuberculosis, using anhydrotetracycline (ATc) as inducer. The systems are based on the Escherichia coli Tn10-derived tet regulatory system and consist of a strong tet operator (tetO)-containing mycobacterial promoter, expression cassettes for the repressor TetR and the chemical inducer ATc. These systems allow gene regulation over two orders of magnitude in Mycobacterium smegmatis and M.tuberculosis. TetR-controlled gene expression was inducer concentration-dependent and maximal with ATc concentrations at least 10- and 20-fold below the minimal inhibitory concentration for M.smegmatis and M.tuberculosis, respectively. Using the essential mycobacterial gene ftsZ, we showed that these expression systems can be used to construct conditional knockouts and to analyze the function of essential mycobacterial genes. Finally, we demonstrated that these systems allow gene regulation in M.tuberculosis within the macrophage phagosome

Gauge Symmetry Enhancement and Radiatively Induced Mass in the Large N Nonlinear Sigma Model

We consider a hybrid of nonlinear sigma models in which two complex projective spaces are coupled with each other under a duality. We study the large N effective action in 1+1 dimensions. We find that some of the dynamically generated gauge bosons acquire radiatively induced masses which, however, vanish along the self-dual points where the two couplings characterizing each complex projective space coincide. These points correspond to the target space of the Grassmann manifold along which the gauge symmetry is enhanced, and the theory favors the non-Abelian ultraviolet fixed point.Comment: 11 pages, REVTEX, typos are corrected, version to appear in Phys. Rev.

Chiral primary cubic interactions from pp-wave supergravity

We explicitly construct cubic interaction light-cone Hamiltonian for the chiral primary system involving the metric fields and the self-dual four-form fields in the IIB pp-wave supergravity. The background fields representing pp-waves exhibit SO(4)*SO(4)*Z_2 invariance. It turns out that the interaction Hamiltonian is precisely the same as that for the dilaton-axion system, except for the fact that the chiral primary system fields have the opposite parity to that of the dilaton-axion fields under the Z_2 transformation that exchanges two SO(4)'s.Comment: 14 pages, A few comments are adde

Duality and Enhanced Gauge Symmetry in 2+1 Dimensions

We investigate the enlarged CP(N) model in 2+1 dimensions. This is a hybrid of two CP(N) models coupled with each other in a dual symmetric fashion, and it exhibits the gauge symmetry enhancement and radiative induction of the finite off-diagonal gauge boson mass as in the 1+1 dimensional case. We solve the mass gap equations and study the fixed point structure in the large-N limit. We find an interacting ultraviolet fixed point which is in contrast with the 1+1 dimensional case. We also compute the large-N effective gauge action explicitly.Comment: 26 pags, latex, 5 .eps figures, typos corrected. To appear in J. Phys.

Gratings with an aperiodic basis: single-mode emission in multi-wavelength lasers

We propose a new class of gratings having multiple spatial frequencies. Their design relies on the use of small aperiodic grating sequences as unit cells whose repetition forms a superlattice. The superlattice provides well-defined Fourier components, while the choice of the unit cell structure enables the selection, modulation or suppression of certain Fourier components. Using these gratings to provide distributed feedback in mid-infrared quantum cascade lasers, we demonstrate simultaneous lasing on multiple well-defined and isolated longitudinal modes, each one having a sidemode suppression ratio of about 20 dB.United States. Air Force Office of Scientific Research (MURI 67N-1069926)Harvard University (Nanoscale Systems and Engineering Center)United States. Air Force (‘Deterministic Aperiodic Structures for Onchip Nanophotonic and Nanoplasmonic Device Applications’ under award no. FA9550-10-1- 0019)National Science Foundation (U.S.) (NSF CAREER Award ECCS-0846651)Georgia Institute of Technology (Steve W. Chaddick Endowed Chair of OptoElectronics