An Open Source Testing Tool for Evaluating Handwriting Input Methods

This paper presents an open source tool for testing the recognition accuracy of Chinese handwriting input methods. The tool consists of two modules, namely the PC and Android mobile client. The PC client reads handwritten samples in the computer, and transfers them individually to the Android client in accordance with the socket communication protocol. After the Android client receives the data, it simulates the handwriting on screen of client device, and triggers the corresponding handwriting recognition method. The recognition accuracy is recorded by the Android client. We present the design principles and describe the implementation of the test platform. We construct several test datasets for evaluating different handwriting recognition systems, and conduct an objective and comprehensive test using six Chinese handwriting input methods with five datasets. The test results for the recognition accuracy are then compared and analyzed.Comment: 5 pages, 3 figures, 11 tables. Accepted to appear at ICDAR 201

Improved analysis of inorganic coal properties based on near-infrared reflectance spectroscopy

A novel method is proposed to improve the analysis accuracy of inorganic properties by adding organic information.</p

Research on concentration and distribution of cadmium in crabs sold in Wenzhou

Objective To investigate the contamination and distribution of cadmium (Cd) in crabs sold in Wenzhou, and instruct consumers to eat healthily. Methods Three crab species were collected from 51 markets in 6 counties and districts of Wenzhou. The content of Cd was determined by inductively coupled plasma mass spectrometry based on GB 5009.268-2016. Results The detection rate of Cd was 100% in 235 samples. The Cd pollution in Portunus crab increase during 2013, 2015 to 2017. The Cd content of muscle and hepatopancreas in Portunus crab and Scylla serrata was higher than that in Eriocheir sinensis Milne-Edwards (P0.05). The distribution of Cd in Portunus crab was hepatopancreas and gonad> pectoral muscle > leg muscle, there was no significant difference of cadmium content in different parts between female and male crabs (P>0.05). Conclusion Cd was mainly concentrated in hepatopancreas, which was irrelevant to crab species, sex and individual difference. Cd content of Portunus crab and Scylla serrata exceeded the standard seriously, especially in hepatopancreas. People should pay more attention to the Cd pollution of crabs, and reduce the intake of hepatopancreas if necessary

Effects of Process Parameters on Microstructure and Mechanical Properties of Semi-Solid Al-7Si-0.5Mg Aluminum Alloy by Gas Induced Semi-Solid Process

Al-7Si-0.5Mg aluminum alloy semi-solid slurry with good spherical grains was prepared by gas induced semi-solid process (GISS) and the effects of both holding time and medium alloy addition on the microstructure of the semi-solid slurry were investigated. These two parameters have a great influence on the solid fraction, the size and the sphericity of the grains. With holding time increased from 85 s to 270 s, the solid phase fraction of the semi-solid slurry decreased from ~0.77 to ~0.67, the average grain size increased from ~95 μm to ~225 μm and the average shape factor decreased from ~0.80 to ~0.33. When medium alloy addition varied in the range of 0.5–2.0 wt%, a better slurry microstructure was obtained at about 1.5 wt%. Compared with the conventional liquid die-casting, the semi-solid die-casting improved the mechanical properties of tensile bars; yield strength, tensile strength and elongation of tensile bars reached ~240 MPa, ~307 MPa and ~8.8% after heat treatment, respectively. In conclusion, GISS process can prepare the semi-solid slurry with uniform and round microstructure, and the semi-solid die-casting can improve mechanical proper ties of Al-7Si-0.5Mg aluminum alloy

Dual-Functional PLGA Nanoparticles Co-Loaded with Indocyanine Green and Resiquimod for Prostate Cancer Treatment

Purpose: With the advance of screening techniques, there is a growing number of low-risk or intermediate-risk prostate cancer (PCa) cases, remaining a serious threat to men's health. To obtain better efficacy, a growing interest has been attracted to develop such emerging treatments as immunotherapy and focal therapy. However, few studies offer guidance on whether and how to combine these modalities against PCa. This study was designed to develop dual-functional nanoparticles (NPs) which combined photothermal therapy (PTT) with immunotherapy and determine the anti-tumor efficacy for PCa treatment. Methods: By a double emulsion technique, the drug nanocarrier, poly(lactic-co-glycolic acid) or PLGA, was applied for co-loading of a fluorescent dye, indocyanine green (ICG) and a toll-like receptor 7/8 (TLR7/8) agonist resiquimod (R848) to synthesize PLGA-ICG-R848 NPs. Next, we determined their characteristic features and evaluated whether they inhibited the cell viability in multiple PCa cell lines. After treatment with PLGA-ICG-R848, the maturation markers of bone marrow-derived dendritic cells (BMDCs) were detected by flow cytometry. By establishing a subcutaneous xenograft model of mouse PCa, we explored both the anti-tumor effect and immune response following the NPs-based laser ablation. Results: With a mean diameter of 157.7 nm, PLGA-ICG-R848 exhibited no cytotoxic effect in PCa cells, but they significantly decreased RM9 cell viability to (3.9 +/- 1.0)% after laser irradiation. Moreover, PLGA-ICG-R848 promoted BMDCs maturation with the significantly elevated proportions of CD11c+CD86+ and CD11c+CD80+ cells. Following PLGA-ICG-R848-based laser ablation in vivo, the decreased bioluminescent signals indicated a significant inhibition of PCa growth, while the ratio of splenic natural killer (NK) cells in PLGA-ICG-R848 was (3.96 +/- 1.88)% compared with (0.99 +/- 0.10)% in PBS group, revealing the enhanced immune response against PCa. Conclusion: The dual-functional PLGA-ICG-R848 NPs under laser irradiation exhibit the anti-tumor efficacy for PCa treatment by combining PTT with immunotherapy