Esophageal Squamous Cell Carcinoma with Marked Eosinophil Infiltration

We report a case of esophageal squamous cell carcinoma (SCC) with marked eosinophil infiltration which was identified postoperatively in the esophageal wall in areas not surrounding the SCC. The eosinophil infiltration was seen in the submucosa, muscle and adventitia, but not in the mucosa. Eosinophilic esophagitis (EoE) is a pathological condition defined as eosinophil infiltration within the esophageal mucosa. Eosinophil infiltration at the invasion front of esophageal SCC is termed tumor-associated tissue eosinophilia (TATE). However, the eosinophil infiltration in this case may be pathologically different from both EoE and TATE. To our knowledge, this is the first report of esophageal SCC with eosinophil infiltration

Eosinophilic gastroenteritis with ascites and diffuse intestinal wall thickening

A 60-year-old woman was admitted to our hospital with abdominal pain and diarrhea. Examination revealed eosinophilia (white blood count, 24,900/ml; eosinophils, 79.9%) and an elevated immunoglobulin E level. Abdominal computed tomography showed fluid collection and diffuse intestinal wall thickening, and biopsy specimens from the stomach, duodenum and colon showed eosinophil infiltration. We diagnosed the patient with eosinophilic gastroenteritis, and started treatment with steroid hormones (predonisolone, 40 mg/day perorally). The patient's symptoms and eosinophilia improved dramatically and she was discharged. Eosinophilic gastroenteritis is an inflammatory disease characterized by eosinophil infiltration into the gastrointestinal tract. It usually involves the stomach and small intestine, but may also involve the entire whole gastrointestinal tract. Although ascites sometimes complicates this disease, massive ascites, as in our patient, is rare. Here we report a case of eosinophilic gastroenteritis with massive ascites and diffuse intestinal wall thickening. Steroid hormones are an effective treatment for this disease, and early diagnosis and the administration of steroid hormones are essential