Causal circuit explanations of behavior: Are necessity and sufficiency necessary and sufficient?

In the current advent of technological innovation allowing for precise neural manipulations and copious data collection, it is hardly questioned that the explanation of behavioral processes is to be chiefly found in neural circuits. Such belief, rooted in the exhausted dualism of cause and effect, is enacted by a methodology that promotes “necessity and sufficiency” claims as the goal-standard in neuroscience, thus instructing young students on what shall reckon as explanation. Here we wish to deconstruct and explicate the difference between what is done, what is said, and what is meant by such causal circuit explanations of behavior. Well-known to most philosophers, yet ignored or at least hardly ever made explicit by neuroscientists, the original grand claim of “understanding the brain” is imperceptibly substituted by the methodologically sophisticated task of empirically establishing counterfactual dependencies. But for the 21st century neuroscientist, after so much pride, this is really an excess of humility. I argue that to upgrade intervention to explanation is prone to logical fallacies, interpretational leaps and carries a weak explanatory force, thus settling and maintaining low standards for intelligibility in neuroscience. To claim that behavior is explained by a “necessary and sufficient” neural circuit is, at best, misleading. In that, my critique (rather than criticism) is indeed mainly negative. Positively, I briefly suggest some available alternatives for conceptual progress, such as adopting circular causality (rather than lineal causality in the flavor of top-down reductionism), searching for principles of behavior(rather than taking an arbitrary definition of behavior and rushing to dissect its “underlying” neural mechanisms), and embracing process philosophy (rather than substance-mechanistic ontologies). Overall, if the goal of neuroscience is to understand the relation between brain and behavior then, in addition to excruciating neural studies (one pillar), we will need a strong theory of behavior (the other pillar) and a solid foundation to establish their relation (the bridge)

Sonoelectrochemical production of hydrogen peroxide at polished boron-doped diamond electrodes

Power ultrasound applied to erosion resistant and mechanically stable free standing highly boron-doped diamond electrodes allows the electrochemical reduction of dioxygen to hydrogen peroxide under conditions of extremely high rates of mass transport and in the presence of cavitation

Movement and Nnumbers: The mathematics behind motor actions

The scope of this mini review is to show as neuromotor control often applies mathematical principles and properties improving efficiency of movements. We reported four examples: harmony of human walking is based on the fractal property of self-similarity because based on the golden ratio, anatomy of human hand follows Fibonacci’s sequence for optimizing grasping, the 2/3 power-law at which curvilinear movements obey, and the possibility of brain to predict the movement of falling objects applying an implicit knowledge of the Newton’s gravitational la