15 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
An overview of manganese recovery by Hydro and Pyro-Metallurgical routes
This review comprises of information about the recovery of manganese through leaching and carbothermic reduction routes. In industrial processes, various critical parameters such as ore size, temperature, pressure, gas atmosphere and ore composition etc. affect the reduction or recovery of Mn from ores. Authors have tried to bring those critical parameters in this review which is currently being considered as important industrial parameters for Mn ore processing. This paper deals with both pyro-metallurgical and hydro-metallurgical routes for Mn ore reduction and gives brief summary about the critical parameters.by Deepak Dwivedi, Navneet Singh Randhawa, Sanjay Saroj and Ranjeet Kumar Jan
Classical and quantum fields on Lorentzian manifolds
We construct bosonic and fermionic locally covariant quantum field theories on curved backgrounds for large classes of fields. We investigate the quantum field and n-point functions induced by suitable states
Otoliths reveal diverse fish communities in Late Oligocene estuarine to deep-water paleoenvironments in southern Zealandia
Genetic diversity and historical biogeography of the Maltese wall lizard, Podarcis filfolensis (Squamata: Lacertidae)
Integrating multidisciplinary instruments for assessing coastal vulnerability to erosion and sea level rise: lessons and challenges from the Adriatic Sea, Italy
Advances in molecular quantum chemistry contained in the Q-Chem 4 program package
© 2014 © 2014 Taylor & Francis.A summary of the technical advances that are incorporated in the fourth major release of the Q-Chem quantum chemistry program is provided, covering approximately the last seven years. These include developments in density functional theory methods and algorithms, nuclear magnetic resonance (NMR) property evaluation, coupled cluster and perturbation theories, methods for electronically excited and open-shell species, tools for treating extended environments, algorithms for walking on potential surfaces, analysis tools, energy and electron transfer modelling, parallel computing capabilities, and graphical user interfaces. In addition, a selection of example case studies that illustrate these capabilities is given. These include extensive benchmarks of the comparative accuracy of modern density functionals for bonded and non-bonded interactions, tests of attenuated second order Møller-Plesset (MP2) methods for intermolecular interactions, a variety of parallel performance benchmarks, and tests of the accuracy of implicit solvation models. Some specific chemical examples include calculations on the strongly correlated Cr2 dimer, exploring zeolite-catalysed ethane dehydrogenation, energy decomposition analysis of a charged ter-molecular complex arising from glycerol photoionisation, and natural transition orbitals for a Frenkel exciton state in a nine-unit model of a self-assembling nanotube.Link_to_subscribed_fulltex