7 research outputs found
Comparative study on alkaloids and their anti-proliferative activities from three Zanthoxylum species
Potential of Zanthoxylum leprieurii as a source of active compounds against drug resistant Mycobacterium tuberculosis
In vitro cytotoxic activity of medicinal plants from Nigeria ethnomedicine on Rhabdomyosarcoma cancer cell line and HPLC analysis of active extracts
Boreal forest conifer extracts: potential natural additives for acrylic polyurethane coatings for the protection of heat-treated jack pine
Isolation and identification of novel α-amylase inhibitors from Euonymus laxiflorus Champ
[[abstract]]Euonymus laxiflorus Champ. (ELC) has been reported to possess potential
antidiabetic activity. The aim of this study is to isolate and identify the active
compounds in ELC extract. Application of effective techniques including Diaoin,
octadecylsilane opened columns, dialysis, and preparative high-performance liquid
chromatography (HPLC) coupled with a biologically guided assay resulted in isolation
of 11 novel active compounds. Five compounds were identified as new α-amylase inhibitors (αAIs), viz. walterolactone A/B β-D-pyranoglucoside (1),
schweinfurthinol 9-O-β-D-pyranoglucoside (10), 1-O-(3-methyl)-butenoyl-myoinositol (11), leonuriside (13), and (3,5-dimethoxy-4-hydroxyphenol) -1-O-β-D-(6′-O-galloyl)-glucopyranoside (21). Among these inhibitors, three compounds (1, 10, 11) were characterized as new. Another six known compounds (2, 9, 16, 17, 18, 19) were determined as phenolic. Notably, six compounds (1, 2, 9, 13, 16, 17) demonstrated significant activity, comparable to or higher than that of acarbose, a commercial antidiabetic drug, based on t test ranking. The relationship between the chemical structures and bioactivity of the inhibitors is also reported.[[notice]]補æ£å®Œ