Trends in office internal gains and the impact on space heating and cooling demands

Internal gains from occupants, equipment and lighting contribute a significant proportion of the heat gains in an office space. Looking at trends in Generation-Y, it appears there are two diverging paths for future ICT demand: one where energy demand is carefully regulated and the other where productivity enhancers such as multiple monitors and media walls causes an explosion of energy demand within the space. These internal gains scenarios were simulated on a variety of different building archetypes to test their influence on the space heating and cooling demand. It was demonstrated that in offices with a high quality facade, internal gains are the dominant factor. As a case study, it was shown that natural ventilation is only possible when the ICT demand is carefully regulated

Proposed psychometer index designed as an aid to the better determination of common fungoid illusions and of the comparative value of mental concepts.

The point around which the present argument hinges is the word illusion. By illusion is meant any error of sense, perception, memory, or representation, or of judgment based upon these which counterfeits reality. The only way to distinguish any form of illusion would be to dispel the conditions unfavorable to the manifestations of healthy concepts. It ought to be strongly impressed that there is no well marked line between the sane and the insane, and scarcely any where illusion is concerned, apart from its permanency

Chandra Phase-resolved Spectroscopy of the High Magnetic Field Pulsar B1509−58

We report on a timing and spectral analysis of the young, high magnetic field rotation-powered pulsar (RPP) B1509−58 using Chandra continuous-clocking mode observation. The pulsar's X-ray light curve can be fit by the two Gaussian components and the pulsed fraction shows moderate energy dependence over the Chandra band. The pulsed X-ray spectrum is well described by a power law with a photon index 1.16(4), which is harder than the values measured with RXTE/PCA and NuSTAR. This result supports the log-parabolic model for the broadband X-ray spectrum. With the unprecedented angular resolution of Chandra, we clearly identified off-pulse X-ray emission from the pulsar, and its spectrum is best fit by a power law plus blackbody model. The latter component has a temperature of ~0.14 keV with a bolometric luminosity comparable to the luminosities of other young and high magnetic field RPPs, and it lies between the temperature of magnetars and typical RPPs. In addition, we found that the nonthermal X-ray emission of PSR B1509−58 is significantly softer in the off-pulse phase than in the pulsed phase, with the photon index varying between 1.0 and 1.8 and anticorrelated with the flux. This is similar to the behavior of three other young pulsars. We interpreted it as different contributions of pair-creation processes at different altitudes from the neutron star surface according to the outer-gap model.postprin

Over-expression of c-Myc oncoprotein in oral squamous cell carcinoma in the South Indian population

Oral neoplasm constitutes a predominant class of cancer that is encountered in South India. This is in large part due to the elevated risk of oncogenesis as a result of the habit of chewing of quids containing betel leaves, areca nut and smokeless tobacco. An array of molecular events are induced during the transformation of the buccal epithelium, among them the over-expression of oncogene products plays a key role. The c-Myc protein, a regulator of a number of key cellular signalling pathways, plays a pivotal role in a number of malignancies. The present study was undertaken to evaluate expression of the c-Myc protein in tumours of the oral cavity from the South Indian population, predominantly oral squamous cell carcinoma (OSCC). The c-Myc protein was over-expressed in 80% of the cases studied. Taking into account the pivotal role demonstrated for c-Myc in tumourigenesis, our observations suggest a key role for Myc oncoprotein in the genesis of OSCC as well as its potential as a therapeutic target in this population

Sign-reversal of the in-plane resistivity anisotropy in hole-doped iron pnictides

The in-plane anisotropy of the electrical resistivity across the coupled orthorhombic and magnetic transitions of the iron pnictides has been extensively studied in the parent and electron-doped compounds. All these studies universally show that the resistivity $\rho_{a}$ across the long orthorhombic axis $a_{O}$ - along which the spins couple antiferromagnetically below the magnetic transition temperature - is smaller than the resistivity $\rho_{b}$ of the short orthorhombic axis $b_{O}$, i. e. $\rho_{a}<\rho_{b}$. Here we report that in the hole-doped compounds Ba$_{1-x}$K$_{x}$Fe$_{2}$As$_{2}$, as the doping level increases, the resistivity anisotropy initially becomes vanishingly small, and eventually changes sign for sufficiently large doping, i. e. $\rho_{b}<\rho_{a}$. This observation is in agreement with a recent theoretical prediction that considers the anisotropic scattering of electrons by spin-fluctuations in the orthorhombic/nematic state.Comment: This paper has been replaced by the new version offering new explanation of the experimental results first reported her

A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD

© 2015 The Author(s). Viral exacerbations of chronic obstructive pulmonary disease (COPD), commonly caused by rhinovirus (RV) infections, are poorly controlled by current therapies. This is due to a lack of understanding of the underlying immunopathological mechanisms. Human studies have identified a number of key immune responses that are associated with RV-induced exacerbations including neutrophilic inflammation, expression of inflammatory cytokines and deficiencies in innate anti-viral interferon. Animal models of COPD exacerbation are required to determine the contribution of these responses to disease pathogenesis. We aimed to develop a short-term mouse model that reproduced the hallmark features of RV-induced exacerbation of COPD. Evaluation of complex protocols involving multiple dose elastase and lipopolysaccharide (LPS) administration combined with RV1B infection showed suppression rather than enhancement of inflammatory parameters compared with control mice infected with RV1B alone. Therefore, these approaches did not accurately model the enhanced inflammation associated with RV infection in patients with COPD compared with healthy subjects. In contrast, a single elastase treatment followed by RV infection led to heightened airway neutrophilic and lymphocytic inflammation, increased expression of tumour necrosis factor (TNF)-α, C-X-C motif chemokine 10 (CXCL10)/IP-10 (interferon γ-induced protein 10) and CCL5 [chemokine (C-C motif) ligand 5]/RANTES (regulated on activation, normal T-cell expressed and secreted), mucus hypersecretion and preliminary evidence for increased airway hyper-responsiveness compared with mice treated with elastase or RV infection alone. In summary, we have developed a new mouse model of RV-induced COPD exacerbation that mimics many of the inflammatory features of human disease. This model, in conjunction with human models of disease, will provide an essential tool for studying disease mechanisms and allow testing of novel therapies with potential to be translated into clinical practice

Risk-based inspection as a cost-effective strategy to reduce human exposure to cysticerci of Taenia saginata in low-prevalence settings

Taenia saginata cysticercus is the larval stage of the zoonotic parasite Taenia saginata, with a life-cycle involving both cattle and humans. The public health impact is considered low. The current surveillance system, based on post-mortem inspection of carcasses has low sensitivity and leads to considerable economic burden. Therefore, in the interests of public health and food production efficiency, this study aims to explore the potential of risk-based and cost-effective meat inspection activities for the detection and control of T. saginata cysticercus in low prevalence settings

Kerr-Newman Black Hole Thermodynamical State Space: Blockwise Coordinates

A coordinate system that blockwise-simplifies the Kerr-Newman black hole's thermodynamical state space Ruppeiner metric geometry is constructed, with discussion of the limiting cases corresponding to simpler black holes. It is deduced that one of the three conformal Killing vectors of the Reissner-Nordstrom and Kerr cases (whose thermodynamical state space metrics are 2 by 2 and conformally flat) survives generalization to the Kerr-Newman case's 3 by 3 thermodynamical state space metric.Comment: 4 pages incl 2 figs. Accepted by Gen. Rel. Grav. Replaced with Accepted version (minor corrections

Augmented reality applications for cultural heritage using Kinect

AbstractThis paper explores the use of data from the Kinect sensor for performing augmented reality, with emphasis on cultural heritage applications. It is shown that the combination of depth and image correspondences from the Kinect can yield a reliable estimate of the location and pose of the camera, though noise from the depth sensor introduces an unpleasant jittering of the rendered view. Kalman filtering of the camera position was found to yield a much more stable view. Results show that the system is accurate enough for in situ augmented reality applications. Skeleton tracking using Kinect data allows the appearance of participants to be augmented, and together these facilitate the development of cultural heritage applications.</jats:p